Publications by authors named "Dongqiang Ma"
Article Synopsis
- Quantum computing offers advanced computational power that could transform drug discovery, but current studies often only serve as basic tests without tackling real-world challenges.
- This research introduces a hybrid quantum computing pipeline that targets actual drug design problems, moving beyond typical studies to create practical solutions.
- The study focuses on two key areas: accurately determining Gibbs free energy for prodrug activation and simulating covalent bond interactions, aiming to incorporate quantum computing into real-world drug development processes.
SFTSV, a tick-borne bunyavirus causing a severe hemorrhagic fever termed as severe fever with thrombocytopenia syndrome (SFTS). To evaluate the potential role of rodents and its ectoparasitic chiggers in the transmission of SFTSV, we collected wild rodents and chiggers on their bodies from a rural area in Qingdao City, Shandong Province, China in September 2020. PCR amplification of the M and L segments of SFTSV showed that 32.
View Article and Find Full Text PDFPCR amplification indicated the minimum infection rate of Rickettsia spp. was 0.66% in Haemaphysalis longicornis ticks collected from Shandong Province, China.
View Article and Find Full Text PDFAnaplasma are tick-borne obligatory intracellular bacteria, which infect humans and other animals. The Anaplasma species carried by ticks in China are not well studied. We collected 3145 questing Haemaphysalis longicornis ticks including 120 larvae, 2460 nymphs and 565 adults from vegetation in Jiaonan County, Shandong Province, China from 2013 to 2015.
View Article and Find Full Text PDFLeptotrombidium scutellare mites, the vector of Orientia tsutsugamushi, have rarely been reported to associate with Rickettsia species. Three hundred nineteen chiggers were collected from the ears of 32 rodents captured in Huangdao District of Qingdao City, China, in October 2015. The chigger samples were tested for Rickettsia, severe fever with thrombocytopenia syndrome virus, and hantavirus by PCR or RT-PCR amplification.
View Article and Find Full Text PDFSeroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Hedgehog from China.
Vector Borne Zoonotic Dis
May 2017
Severe fever with thrombocytopenia syndrome, an emerging hemorrhagic fever, is caused by severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne bunyavirus. Information regarding SFTSV animal hosts is very limited. In this study, we showed that 64% (9/14) of hedgehogs in Shandong Province, China were seropositive to SFTSV antibody, suggesting that hedgehog could be a vertebrate parasitifer for SFTSV.
View Article and Find Full Text PDFDetection of Imjin Virus and Seoul Virus in Crocidurine Shrews in Shandong Province, China.
Vector Borne Zoonotic Dis
June 2017
Article Synopsis
- Hantaviruses have been found in insectivores across multiple continents, with the Imjin virus (MJNV) first isolated from shrews in South Korea in 2009.
- A study conducted in 2014 in Shandong Province, China, used RT-PCR to identify hantavirus species in captured shrews and rodents.
- The results showed that 10.7% of Crocidura shrews were infected with MJNV, while none of the rodents were infected; a small percentage of shrews also tested positive for the Seoul virus (SEOV), confirming shrews as key hosts for MJNV.
Article Synopsis
- Hemorrhagic fever with renal syndrome (HFRS) is primarily linked to rodents like Apodemus agrarius and Rattus norvegicus, known carriers of hantaviruses.
- A study conducted in Qingdao City, China, from 2010 to 2014 examined the relationship between HFRS cases, rodent capture rates, and hantavirus infection rates among local rodents.
- Results indicated that the incidence of HFRS correlated with the capture rates of Mus musculus, a nontraditional hantavirus host, rather than the expected primary hosts, suggesting a potential shift in the dynamics of hantavirus transmission.
Detection of a Novel Ehrlichia Species in Haemaphysalis longicornis Tick from China.
Vector Borne Zoonotic Dis
June 2016
We collected 2460 Haemaphysalis longicornis ticks from vegetation in Jiaonan County, Shandong Province, in June of 2013 and Daishan County, Zhejiang Province, China, in May of 2015. The tick DNA was subsequently amplified with nested polymerase chain reaction using Ehrlichia common 16S rRNA gene primers and Ehrlichia ewingii species-specific groEL and gltA primers. We found 0.
View Article and Find Full Text PDFSevere fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia caused by SFTS virus (SFTSV), a newly discovered phlebovirus. The Haemaphysalis longicornis tick has been suspected to be the vector of SFTSV. To determine whether SFTSV can be transmitted among ticks, from ticks to animals, and from animals to ticks, we conducted transmission studies between developmental stages of H.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied small mammals, specifically rodents and shrews, in China to assess their role in hosting the severe fever with thrombocytopenia syndrome virus (SFTSV).
- Serum samples collected in 2013 were tested for the presence of SFTSV antibodies and RNA.
- The findings indicate that these small mammals likely serve as hosts for the SFTSV.