Effects of 25-hydroxyvitamin D on bone microstructure in T2MD rats.

Objective: This study aims to explore the effects of 25-hydroxyvitamin D on the bone microstructure of rats with type 2 diabetes mellitus (T2MD).

Methods: 40 male Wistar rats were randomly selected for T2MD modeling and injected with streptozotocin solution. The rats in the control group (n=19) were fed with common feed.

Photonic radio-frequency dissemination via optical fiber with high-phase stability.

We demonstrate a photonic radio-frequency transmission system via optical fiber. Optical radio-frequency signal is generated utilizing a Mach-Zehnder modulator based on double-side-band with carrier suppression modulation scheme. The phase error induced by optical fiber transmission is transferred to an intermediate frequency signal by the dual-heterodyne phase error transfer scheme, and then canceled by a phase locked loop.

Distribution of high-stability 100.04 GHz millimeter wave signal over 60 km optical fiber with fast phase-error-correcting capability.

We demonstrate a phase-stabilized remote distribution of 100.04 GHz millimeter wave signal over 60 km optical fiber. The phase error of the remote millimeter wave signal induced by fiber transmission delay variations is detected by dual-heterodyne phase error transfer and corrected with a feedback system based on a fast response acousto-optic frequency shifter.

Photonic generation of millimeter and terahertz waves with high phase stability.

Optical generation of highly stable millimeter and terahertz waves is proposed and experimentally demonstrated. The optical-fiber-path-induced phase fluctuation is identically transferred to a 40 MHz intermediate frequency by using dual-heterodyne phase error transfer, then canceled by a phase-locked loop. Based on the scheme, highly stable signals within the frequency range from 25 GHz to 1 THz are generated, and the phase jitter is decreased from 2.

Clinical efficacy of CyberKnife combined with chemotherapy and hyperthermia for advanced non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) is responsible for at least 80% of all lung tumors and has a poor prognosis, since 75% of NSCLCs are first diagnosed at an advanced stage. This study was conducted to evaluate the therapeutic efficacy of CyberKnife in combination with chemotherapy and hyperthermia for selected patients with advanced non-small cell lung cancer (NSCLC). Clinical charts, imaging and pathology reports of patients with advanced NSCLC who underwent CyberKnife therapy in our Tumor Therapy Center were retrospectively reviewed.

Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway.

Accumulating evidence indicates that aged black garlic extract (ABGE) may prove beneficial in preventing or inhibiting oncogenesis; however, the underlying mechanisms have not been fully elucidated. The present study aimed to investigate the effects of ABGE on the proliferation and apoptosis of HT29 colon cancer cells. Our results demonstrated that ABGE inhibited HT29 cell growth via the induction of apoptosis and cell cycle arrest.

Optimized treatment with RF thermotherapy and immunotherapy combined with CyberKnife for advanced high-risk tumors: A clinical trial report.

This study was conducted to evaluate the application value of optimized treatment with radiofrequency (RF) thermotherapy and immunotherapy combined with CyberKnife for advanced high-risk tumors. The database of 1,013 patients with 2,136 tumor lesions and 1,237 target areas who underwent treatment with CyberKnife between November, 2010 and November, 2012, was retrospectively reviewed. We randomly assigned 505 eligible patients (observation group) to RF thermotherapy and adoptive immunotherapy with cytokine-induced killer cells and the remaining 508 patients (control group) to no adjuvant treatment.

Distribution of high-stability 10 GHz local oscillator over 100 km optical fiber with accurate phase-correction system.

We have developed a radio-frequency local oscillator remote distribution system, which transfers a phase-stabilized 10.03 GHz signal over 100 km optical fiber. The phase noise of the remote signal caused by temperature and mechanical stress variations on the fiber is compensated by a high-precision phase-correction system, which is achieved using a single sideband modulator to transfer the phase correction from intermediate frequency to radio frequency, thus enabling accurate phase control of the 10 GHz signal.

CyberKnife therapy of 24 multiple brain metastases from lung cancer: A case report.

Brain metastasis is a significant cause of morbidity and mortality and a critical complication of non-central nervous system primary carcinoma. The present study describes the clinical case of a 46-year-old male with lung cancer and life-threatening brain metastases. The patient was diagnosed with lung cancer with a clinical stage of T2N0M1 (stage IV).

Designing zonal organization into tissue-engineered cartilage.

Cartilage tissue engineering strategies generally result in homogeneous tissue structures with little resemblance to the native zonal organization of articular cartilage. The objective of this study was to use bilayered photopolymerized hydrogels to organize zone-specific chondrocytes in a stratified framework and study the effects of this three-dimensional coculture system on the properties of the engineered tissue. Superficial and deep zone chondrocytes from bovine articular cartilage were photoencapsulated in separate hydrogels as well as in adjacent layers of a bilayered hydrogel.

The functional environment of chondrocytes within cartilage subjected to compressive loading: a theoretical and experimental approach.

A non-invasive methodology (based on video microscopy, optimized digital image correlation and thin plate spline smoothing technique) has been developed to determine the intrinsic tissue stiffness (H(a)) and the intrinsic fixed charge density (c(0)(F)) distribution for hydrated soft tissues such as articular cartilage. Using this technique, the depth-dependent inhomogeneous parameters H(a)(z) and c(0)(F)(z) were determined for young bovine cartilage and incorporated into a triphasic mixture model. This model was then used to predict the mechanical and electrochemical events (stress, strain, fluid/osmotic pressure, and electrical potentials) inside the tissue specimen under a confined compression stress relaxation test.