Research on the High-Temperature Stability of Twin-Screw Desulphurised Rubber Powder Composite SBS-Modified Asphalt and Its Mixtures.

To analyse the differences in the high-temperature performance of twin-screw desulphurised rubber powder/undesulphurised rubber powder composite SBS-modified asphalt and its mixes. This paper analyses the performance differences between desulphurised rubber powder composite SBS-modified asphalt (ACR/SBS), rubber powder composite SBS-modified asphalt (CR/SBS) and SBS-modified asphalt and their mixtures by multi-stress repeated creep recovery (MSCR) and submerged Hamburg rutting tests. In addition, fluorescence microscopy was used to reveal the micro-mechanisms underlying the differences in the high-temperature performance of the three asphalts.

Lignocellulosic biomass as promising substrate for polyhydroxyalkanoate production: Advances and perspectives.

The depletion of fossil resources, coupled with global warming and adverse environmental impact of traditional petroleum-based plastics, have necessitated the discovery of renewable resources and innovative biodegradable materials. Lignocellulosic biomass (LB) emerges as a highly promising, sustainable and eco-friendly approach for accumulating polyhydroxyalkanoate (PHA), as it completely bypasses the problem of "competition for food". This sustainable and economically efficient feedstock has the potential to lower PHA production costs and facilitate its competitive commercialization, and support the principles of circular bioeconomy.

Effects of Mandibular Advancement Device on Genioglossus of Rabbits in Obstructive Sleep Apnea Through PINK1/Parkin Pathway.

Background: Early treatment of mandibular advancement device (MAD) reverses the abnormal changes resulting from obstructive sleep apnoea (OSA), but the underlying mechanism is not clear. We analysed the changes of genioglossus function before and after MAD treatment in OSA rabbits and explored the mechanism of mitochondrial autophagy.

Methods: Eighteen male New Zealand rabbits were randomised into three groups: the control group, Group OSA, and Group MAD.

Tongbian formula alleviates slow transit constipation by increasing intestinal butyric acid to activate the 5-HT signaling.

Slow transit constipation (STC) is a long-lasting and prevalent intestinal condition, marked by hard, dry feces. The primary cause of STC may be attributed to an imbalance in the gut's microbial community and alterations in its metabolic byproducts. Tongbian formula (TB), a traditional Chinese medicinal formula, has been used to treat STC and shows a great effect on relieving constipation.

Hydrogen peroxide fluorescent probe-monitored butyric acid inhibition of the ferroptosis process.

Short-chain fatty acids, such as butyrate, play pivotal roles in various physiological processes within the human body. Recent advances in understanding cell death pathways, specifically ferroptosis, have unveiled unique opportunities for therapeutic development. Ferroptosis is linked to iron accumulation and oxidative stress, whereas butyrate has emerged as a cellular protector against oxidative stress, potentially inhibiting ferroptosis.

Epidemiology of multimorbidity associated with atherosclerotic cardiovascular disease in the United States, 1999-2018.

Background: The multimorbidity of Atherosclerotic cardiovascular disease (ASCVD) and many other chronic conditions is becoming common. This study aimed to assess multimorbidity distribution in ASCVD among adults in the United States from 1999 to 2018.

Methods: This cross-sectional survey from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 using stratified multistage probability design.

Effects and central mechanism of electroacupuncture and MRI-navigated rTMS for PSD: study protocol for an fMRI-based single-center, randomized, controlled, open-label trial.

Background: Post-stroke depression (PSD) is the most common mental complication after stroke and has a serious impact on functional outcomes and quality of life for stroke patients. Antidepressants are the first-line treatment for PSD; however, many reported side effects remain. Clinical research and practice guidelines have shown that electro-acupuncture (EA) or rTMS have a positive effect on PSD.

Clinical value-oriented research paradigm about inheritance and innovation development of TCM dominant diseases.

Modern medicine has made remarkable achievements in safeguarding people's life and health, however, it is increasingly found that in the face of complex diseases, selective targeting of single target is often difficult to produce a comprehensive rehabilitation effect, and is prone to induce drug resistance, toxic side effects. Traditional Chinese medicine (TCM) has a long history of clinical application, and its clinical value in the treatment of complex diseases such as cardiovascular and cerebrovascular diseases, digestive diseases, skin diseases, rheumatism and immunity diseases, and adjuvant treatment of tumors has been proven to have obvious advantages. However, its modern research is relatively lagging behind, and in the face of the aging society and the characteristics of the modern disease spectrum, the traditional knowledge-driven research paradigm seems to be stuck in a bottleneck and difficult to make greater breakthroughs.

Biosynthesis of poly(β-L-malic acid) from rubberwood enzymatic hydrolysates in co-fermentation by Aureobasidium pullulans.

Co-fermentation of multiple substrates has emerged as the most effective method to improve the yield of bioproducts. Herein, sustainable rubberwood enzymatic hydrolysates (RWH) were co-fermented by Aureobasidium pullulans to produce poly(β-L-malic acid) (PMA), and RWH + glucose/xylose was also investigated as co-substrates. Owing to low inhibitor concentration and abundant natural nitrogen source content of RWH, a high PMA yield of 0.

Vacancy-Modified Porous g-CN Nanosheets Controlled by Physical Activation for Highly Efficient Visible-Light-Driven Hydrogen Evolution and Organics Degradation.

As a promising photocatalyst material, g-CN has great application potential in energy production and environmental improvement. In this work, surface-modified g-CN nanosheets with excellent stability and high photocatalytic activity were successfully synthesized by physical steam activation. The charge transfer rate of carbon nitride was improved due to the synergistic effect of nitrogen defect and oxygen doping caused by steam activation.

Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment.

Cognitive dysfunction is one of the common central nervous systems (CNS) complications of diabetes mellitus, which seriously affects the quality of life of patients and results in a huge economic burden. The glymphatic system dysfunction mediated by aquaporin-4 (AQP4) loss or redistribution in perivascular astrocyte endfeet plays a crucial role in diabetes-induced cognitive impairment (DCI). However, the mechanism of AQP4 loss or redistribution in the diabetic states remains unclear.

Positive correlation between snoring and dyslipidemia in adults: results from NHANES.

Background: A few studies have shown that snoring, in certain populations, is associated with dyslipidemia. However, there are currently no large-scale national studies available that explore this association. Thus, for further clarification, studies using a large sample of the general population need to be conducted.

Strategy for economical and enhanced polyhydroxyalkanoate production from synergistic utilization of palm oil and derived wastewater by activated sludge.

The potential of palm oil and derived wastewater pretreated by enzyme as co-substrates to accumulate polyhydroxyalkanoate (PHA) rich in short and medium-chain-length monomers under two feeding strategies was evaluated batchwise through mixed microbial cultures (MMCs) in activated sludge. A terpolymer with the maximum PHA content of 30.5 wt%, volumetric yield of 0.

Deep learning and machine intelligence: New computational modeling techniques for discovery of the combination rules and pharmacodynamic characteristics of Traditional Chinese Medicine.

It has been increasingly accepted that Multi-Ingredient-Based interventions provide advantages over single-target therapy for complex diseases. With the growing development of Traditional Chinese Medicine (TCM) and continually being refined of a holistic view, "multi-target" and "multi-pathway" integration characteristics of which are being accepted. However, its effector substances, efficacy targets, especially the combination rules and mechanisms remain unclear, and more powerful strategies to interpret the synergy are urgently needed.

Effects of Different Natural Factors on Rheological Properties of SBS Modified Asphalt.

Typical climatic environments such as UV radiation, high temperature and strong wind in cold and arid regions have a significant effect on asphalt aging. The intent of this work is to reveal the evolution law of natural aging of SBS-modified asphalt under the complex adverse climate environment in cold and arid regions. Furthermore, the contribution rate of various environmental factors of natural aging of asphalt in cold and arid regions was analyzed.

Storax Inhibits Caveolae-Mediated Transcytosis at Blood-Brain Barrier After Ischemic Stroke in Rats.

Blood-brain barrier (BBB) disruption following ischemic stroke (IS) contributes to hemorrhagic transformation, brain edema, increased neural dysfunction, secondary injury, and mortality. The prevailing view attributes the destruction of tight junction proteins (TJs) to the resulting BBB damage following IS. However, recent studies define a stepwise impairment of the transcellular barrier followed by the paracellular barrier which accounts for the BBB leakage in IS.

Efficient and economical production of polyhydroxyalkanoate from sustainable rubber wood hydrolysate and xylose as co-substrate by mixed microbial cultures.

Using co-substrate to accumulate polyhydroxyalkanoate (PHA) is an efficient approach to reduce production cost and improve yield of PHA. In the study, PHA was biosynthesized under full aerobic mode by using rubber wood hydrolysate and xylose co-substrate as the carbon source. The effects of co-substrate on PHA production, microbial community and carbon conversion were explored.

Achieving polyhydroxyalkanoate production from rubber wood waste using mixed microbial cultures and anaerobic-aerobic feeding regime.

In the past few years, creating value-added products has become the best choice to pretreat biomass waste. For instance, the fermentable sugar obtained after pretreatment bioconversion into valuable bioproducts, biopolymer as a typical representative, has become a potential strategy. In particular, the production of biopolymer polyhydroxyalkanoate (PHA) by mixed microbial cultures in waste activated sludge can be regarded as a promising alternative to traditional petrochemical plastics.

Post-stroke treatment of storax improves long-term outcomes of stroke in rats.

Ethnopharmacological Relevance: The lack of widely applicable pharmacological treatments for ischemic stroke patients has led to a growing interest in traditional medicine. The identification of pharmacologically active components of the clinically used traditional medicine has been considered translationally significant. SuHeXiang Wan is a prescription containing 15 herbs approved by Chinese National Drug Administration (CNDA) for treating ischemic stroke.

Bioconversion of renewable lignocellulosic biomass into multicomponent substrate via pressurized hot water pretreatment for bioplastic polyhydroxyalkanoate accumulation.

The pretreatment of lignocellulosic biomass (LB) has become an important process to reduce the cost of polyhydroxyalkanoate (PHA) production. In this study, an economical and effective pressurized hot water pretreatment was used to investigate on bioconversion of four typical LB (rubber wood, sugarcane bagasse, sorghum stalk, cassava stalk) into reducing sugar, then as feedstock to accumulate PHA by mixed microbial cultures. The results showed that pretreatment changed the surface morphology of LB and further improved saccharification efficiency.

Duzhong Fang Attenuates the POMC-Derived Neuroinflammation in Parkinsonian Mice.

Background: Neuroinflammation and microglia reactivity are now recognized to be features of Parkinson's disease (PD). Thus, microglia phenotype is a potential new target for developing treatments against PD. Duzhong Fang (DZF) is a traditional Chinese medicine (TCM) prescription.

Insights into enhanced polyhydroxyalkanoate production by the synergistic use of waste wood hydrolysate and volatile fatty acids by mixed microbial cultures.

The feasibility of producing polyhydroxyalkanoate (PHA) from pretreated waste wood hydrolysate and volatile fatty acids (VFAs) from sewage fermented products as co-substrate feedstock through mixed microbial cultures (MMCs) process was explored. The results showed that the addition of co-substrate shortened the cycle of PHA reaching the maximum and increased the proportion of 3-hydroxyvalerate (3HV) monomer. Compared with N-excess supply, almost 1.

Creating biotransformation of volatile fatty acids and octanoate as co-substrate to high yield medium-chain-length polyhydroxyalkanoate.

Using mixed microbial consortium (MMC) to accumulate polyhydroxyalkanoate (PHA) is an effective strategy to solve high production cost and reduce the amount of excess sludge. In this study, a process for the production of short-chain-length and medium-chain-length PHA using volatile fatty acids (VFAs) from pretreated wood hydrolysate synergistic with octanoate as co-substrate was proposed. The effects of co-substrate ratios on PHA accumulation ability and physical properties were investigated.