Clinically relevant immune subtypes based on alternative splicing landscape of immune-related genes for lung cancer advanced PPPM approach.

Background: Alternative splicing (AS) occurs in the process of gene post-transcriptional process, which is very important for the correct synthesis and function of protein. The change of AS pattern may lead to the change of expression level or function of lung cancer-related genes, and then affect the occurrence and development of lung cancers. The specific AS pattern might be used as a biomarker for early warning and prognostic assessment of a cancer in the framework of predictive, preventive, and personalized medicine (PPPM; 3PM).

Expediting Ethylbenzene Oxidation via a Bimetallic Cobalt-Manganese Spinel Structure with a Modulated Electronic Environment.

The catalytic oxidation of ethylbenzene (EB) into acetophenone (AP) is a vibrant area, with a growing number of researchers paying attention to this thematic investigation. Herein, we demonstrate that spinel-type (Co,Mn)(Co,Mn)O can function as an efficient catalyst for the solvent-free oxidation of EB with molecular oxygen. The incorporation of Mn into the CoO network can break the local structural symmetry of Co-O-Co linkages due to the bond competition, inducing the formation of an asymmetrical Co-O-Mn configuration with an electron local exchange interaction.

Treatment of hospital wastewater by electron beam technology: Removal of COD, pathogenic bacteria and viruses.

The effective treatment of hospital sewage is crucial to human health and eco-environment, especially during the pandemic of COVID-19. In this study, a demonstration project of actual hospital sewage using electron beam technology was established as advanced treatment process during the outbreak of COVID-19 pandemic in Hubei, China in July 2020. The results indicated that electron beam radiation could effectively remove COD, pathogenic bacteria and viruses in hospital sewage.

Current developments of robotic hip exoskeleton toward sensing, decision, and actuation: A review.

The aging population is now a global challenge, and impaired walking ability is a common feature in the elderly. In addition, some occupations such as military and relief workers require extra physical help to perform tasks efficiently. Robotic hip exoskeletons can support ambulatory functions in the elderly and augment human performance in healthy people during normal walking and loaded walking by providing assistive torque.

Neck circumference and waist circumference associated with cardiovascular events in type 2 diabetes (Beijing Community Diabetes Study 23).

Obesity increases the risk of developing cardiovascular disease and other metabolic diseases. We intended to compare three different anthropometric indicators of obesity, in predicting the incidence of cardiovascular events in Chinese type 2 diabetes. Beijing Community Diabetes Study was a prospective multi-center study conducted in Beijing community health centers.

Catalytic ozonation of norfloxacin using CoO/C composite derived from ZIF-67 as catalyst.

In this study, CoO-carbon composite was synthesized by calcined metal organic framework (MOF) ZIF-67 and used as efficient catalysts for ozonation of norfloxacin (NOF). The MOF-derived CoO-C composite remained similar polyhedrons structure of ZIF-67, suggesting that CoO was well-dispersed in CoO-C composite. Furthermore, a larger amount of surface carbon-oxygen functional groups were distributed on CoO-C composite, which resulted in the diversification of active sites for catalytic ozonation reaction.

A data-driven respiratory motion estimation approach for PET based on time-of-flight weighted positron emission particle tracking.

Purpose: Respiratory motion of patients during positron emission tomography (PET)/computed tomography (CT) imaging affects both image quality and quantitative accuracy. Hardware-based motion estimation, which is the current clinical standard, requires initial setup, maintenance, and calibration of the equipment, and can be associated with patient discomfort. Data-driven techniques are an active area of research with limited exploration into lesion-specific motion estimation.

Correlation of serum meteorin-like concentrations with diabetic nephropathy.

Objective: Meteorin-like (Metrnl), a secreted myokine, is induced in white adipose tissue during cold exposure and in muscle after exercise. The present investigation aims to determine the hypothesis that serum Metrnl concentrations are correlated with diabetic nephropathy (DN).

Methods: The investigation was performed in a population of 221 patients with type 2 diabetes mellitus (T2DM) and 74 healthy subjects.

Pavement Crack Detection from Mobile Laser Scanning Point Clouds Using a Time Grid.

This paper presents a novel algorithm for detecting pavement cracks from mobile laser scanning (MLS) data. The algorithm losslessly transforms MLS data into a regular grid structure to adopt the proven image-based methods of crack extraction. To address the problem of lacking topology, this study assigns a two-dimensional index for each laser point depending on its scanning angle or acquisition time.

Respiratory Motion Correction Using A Novel Positron Emission Particle Tracking Technique: A Framework Towards Individual Lesion-Based Motion Correction.

Respiratory motion during PET/CT imaging is a matter of concern due to degraded image quality and reduced quantitative accuracy caused by motion artifacts. One class of motion correction methods relies on hardware-based respiratory motion tracking systems in order to use respiratory cycles for correcting motion artifacts. Another class of hardware-free methods extract motion information from the reconstructed images or sinograms.

An isocenter estimation tool for proton gantry alignment.

A novel tool has been developed to automate the process of locating the isocenter, center of rotation, and sphere of confusion of a proton therapy gantry. The tool uses a Radian laser tracker to estimate how the coordinate frame of the front-end beam-line components changes as the gantry rotates. The coordinate frames serve as an empirical model of gantry flexing.