Bioimaging and Sensing Thiols In Vivo and in Tumor Tissues Based on a Near-Infrared Fluorescent Probe with Large Stokes Shift.

The well-known small-molecule biothiols have been used to maintain the normal metabolism of peroxy radicals, forming protein structures, resisting cell apoptosis, regulating metabolism, and protecting the homeostasis of cells in the organism. A large amount of research has found that abnormal levels of the above biothiols can cause some adverse diseases, such as changes in hair pigmentation, a slower growth rate, delayed response, excessive sleep and skin diseases. In order to further investigate the exact intracellular molecular mechanism of biothiols, it is imperative to explore effective strategies for real-time biothiol detection in living systems.

Biao and Ben Acupoints Regulate Mitochondrial Function Through P2X Receptor to Improve Myocardial Ischemia.

Context: Ischemic heart disease is a common disease in older surgical patients. The current treatments for myocardial ischemia mainly restore blood flow to an extent, but reperfusion inevitably causes reperfusion injury. Single-point acupuncture and moxibustion can strengthen the body's resistance and eliminate pathogenic factors, but medical practitioners haven't considered matching acupoints in treatments for myocardial ischemia.

Effects of GLP-1 on ovarian dysfunction in polycystic ovary syndrome: A protocol for systematic review and meta-analysis.

Background: Polycystic ovary syndrome (PCOS) is a frequent endocrine disorder in women, it is the principal cause of infertility and amenorrhea. Due to its high recurrence rate, poor prognosis and serious complications, more works on the research of PCOS are needed. Therefore, we performed a protocol for systematic review and meta-analysis to investigate the efficacy and safety of glucagon-like peptide-1 receptor agonists on ovarian dysfunction in PCOS.

Simultaneous Discrimination of Cys/Hcy and GSH With Simple Fluorescent Probe Under a Single-Wavelength Excitation and its Application in Living Cells, Tumor Tissues, and Zebrafish.

Owing to the important physiological sits of biothiols (Cys, Hcy, and GSH), developing accurate detection methods capable of qualitative and quantitative analysis of biothiols in living systems is needed for understanding the biological profile of biothiols. In this work, we have designed and synthesized a 4'-hydroxy-[1,1'-biphenyl]-4-carbonitrile modified with NBD group-based fluorescent probe, BPN-NBD, for sensitive detection of Cys/Hcy and GSH by dual emission signals via a single-wavelength excitation. BPNNBD exhibited an obvious blue fluorescence (λem = 475 nm) upon the treatment with GSH and reacted with Cys/Hcy to give a mixed blue-green fluorescence (λem = 475 and 545 nm).

SRS suppression in multi-kW fiber lasers with a multiplexed CTFBG.

In this paper, we present experimental studies on newly developed multiplexed chirped tilted fiber Bragg gratings (MCTFBGs) for stimulated Raman scattering (SRS) suppression for high-power fiber laser systems. The MCTFBG device is composed of five continuous segments of chirped tilted fiber Bragg gratings (CTFBGs), which are inscribed into the large-mode-area (LMA, 25/400μm) fibers. The SRS suppression capability of the MCTFBG device has been successfully demonstrated with a master oscillator power amplification (MOPA) fiber laser system at the output level of 3.