Treatment methods in traditional Chinese medicine (TCM) are foundational to their theoretical, methodological, formulaic, and pharmacological systems, significantly contributing to syndrome differentiation and therapy. The principle of "promoting urination to regulate bowel movements" is a common therapeutic approach in TCM. The core concept is "promoting the dispersion and drainage of water dampness, regulating urination to relieve diarrhea," yet its scientific underpinning remains unclear.
View Article and Find Full Text PDFIntroduction: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.
Methods: Cancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC.
Objectives: Recent studies have increasingly demonstrated that a multiplatform water environment combined with lard gavage is an effective method for establishing a mouse model of diarrhea. However, the interactions between intestinal microorganisms and diarrhea, as well as the relationships among energy metabolism, fluid balance, and gastrointestinal function in this model, remain poorly understood.
Methods: Building on previous research, this study aimed to optimiz and replicate a multiplatform water environment combined with a lard gavage model.
Increasing evidence highlights the importance of immune mechanoregulation in establishing and sustaining tumor-specific cytotoxicity required for desirable immunotherapeutic outcomes. However, the molecular connections between mechanobiological inputs and outputs and the designated immune activities remain largely unclear. Here, we show that partial inhibition of non-muscle myosin II (NM II) augmented the traction force exerted by T cells and potentiated T cell cytotoxicity against tumors.
View Article and Find Full Text PDFEcotoxicol Environ Saf
June 2024
The distribution of polycyclic aromatic hydrocarbons (PAHs) in the ocean is affected by the sorption-desorption process of sediment particles. This process is determined by the concentration of PAHs in seawater, water temperature, and organic matter content of sediment particles. Quantitative relationships between the net sorption rates (=the difference of sorption and desorption rates) and these factors have not been established yet and used in PAH transport models.
View Article and Find Full Text PDFIn chronic liver diseases, hepatic stellate cells (HSCs) are induced to form the myofibroblasts responsible for scar formation, leading to liver fibrosis and cirrhosis. Here, single-cell RNA sequencing with in vivo lineage tracing in nonalcoholic steatohepatitis (NASH) model mice reveals a subpopulation of HSCs transitioning back to a state resembling their developmental precursors, mesothelial cells (MCs), after liver injury. These damage-associated intermediates between HSCs and MCs (DIHMs) can be traced with a dual recombinase system by labeling Krt19-expressing cells within prelabeled Pdgfrb HSCs, and DIHMs highly express inflammation- and fibrosis-associated genes.
View Article and Find Full Text PDFThis study takes the slider-crank mechanism with revolute joint and translational joint as the research object and studies the contact force model of the clearance joint and the influence of the hybrid clearance joints on the nonlinear dynamic behavior of the mechanism. A modified contact force model is established based on the simplified elastic oscillator model, which can be used as a normal force in clearance joint. In the new contact force model, the component n of the indentation depth can be arbitrarily selected and it can support the calculation of contact force for both fully elastic recovery, non-elastic recovery and fully inelastic recovery.
View Article and Find Full Text PDFPancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies. Metastasis is a complicated multistep process, which is determined by complex genetic alterations. Despite the identification of many metastasis-related genes, distinguishing the drivers from numerous passengers and establishing the causality in cancer pathophysiology remains challenging.
View Article and Find Full Text PDFPurpose: To develop and evaluate a sequence in which water excitation with lipid insensitive binomial off-resonant radio frequency excitation (LIBRE) pulses is incorporated into three-dimensional (3D) variable flip angle fast spin echo (LIBRE-vf-FSE) for fat-free and large field of view imaging at 3 Tesla (T).
Materials And Methods: Numerical simulation was conducted to optimize the parameters of LIBRE pulses, including the flip angle, pulse duration, and frequency offset, for maximizing the fat suppression effect of the proposed LIBRE-vf-FSE sequence. The sequence was then implemented at 3 T and assessed in phantoms, lower extremity imaging of 8 healthy volunteers, and head/neck imaging of 5 healthy volunteers.
Background: Distant metastasis is the prominent factor for cancer-induced death of gastric cancer in which peritoneum is one of the dominating targets of gastric cancer metastasis. However, there is still a lack of effective predictive indicators and treatment methods for gastric cancer patients with peritoneal metastasis.
Methods: A clustering assay was used to investigate the cell aggregates formation ability.
In β-thalassemia, free α-globin chains are unstable and tend to aggregate or degrade, releasing toxic heme, porphyrins and iron, which produce reactive oxygen species (ROS). α-Hemoglobin-stabilizing protein (AHSP) is a potential modifier of β-thalassemia due to its ability to escort free α-globin and inhibit the cellular production of ROS. The influence of AHSP on the redox equilibrium raises the question of whether AHSP expression is regulated by components of ROS signaling pathways and/or canonical redox proteins.
View Article and Find Full Text PDFACS Appl Mater Interfaces
October 2019
In this work, platinum single-atom enhanced mushroom-based carbon (Pt/MC) materials have been facilely synthesized and served as novel electrode materials in lithium-ion batteries (LIBs). The as-synthesized Pt/MC active material shows a uniform dispersion of isolated Pt atoms on an MC support with high specific surface area and large total pore volume. As a negative electrode material for LIBs, the Pt/MC exhibits excellent electrochemical properties, which retains a capacity of 846 mA h g after 800 cycles at 2 A g and 349 mA h g (near to the theoretical capacity of graphite) after 6000 cycles at a high current density of 5 A g.
View Article and Find Full Text PDFBackground: Acyl-CoA dehydrogenase long chain (ACADL) was revealed to have a correlation with malignant progression of cancer. However, whether ACADL plays a role in clinical therapy remains unclear. The clinicopathological role of ACADL in esophageal squamous cell carcinoma (ESCC) will be discussed in this study.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with high proliferative and metastatic phenotypes. CDCA7, a new member of the cell division cycle associated family of genes, is involved in embryonic development and dysregulated in various types of human cancer. However, the biological role and molecular mechanism of CDCA7 in TNBC have not been defined.
View Article and Find Full Text PDFTo select the best interestingness measure appropriate for evaluating the correlation between Chinese medicine (CM) syndrome elements and symptoms, 60 objective interestingness measures were selected from different subjects. Firstly, a hypothesis for a good measure was proposed. Based on the hypothesis, an experiment was designed to evaluate the measures.
View Article and Find Full Text PDFObjective: To simplify the TCM pattern of the zang-fu organs.
Methods: A database of zang-fu syndromes was established. The relationship between the zang-fu syndromes was analyzed by means of frequency analysis, association rule, and phi-coefficient correlation.