Development of a direct dilution method for the simultaneous determination of 40 metal and non-metallic elements in urine and blood samples within 6 min using ICP-MS: Application of comprehensive biomonitoring of elementomic phenotypes of individuals in paired biological samples.

The deficiency and overnutrition of both metal and non-metallic elements in human body can pose harmful effects to human health. Therefore, it is necessary to determination of elements in human body for assessing health risk of elementome. In this study, a simple and accurate biomonitoring approach was developed for quantifying 40 elements in biological samples within 6 min using a direct dilution method combined with inductively coupled plasma mass spectrometry (ICP-MS).

Development and validation of a GC-MS/MS method for the determination of iodoacetic acid in biological samples.

Iodoacetic acid (IAA) is a halogenated disinfection by-product of growing concern due to its high cytotoxicity, genotoxicity, endocrine disruptor effects, and potential carcinogenicity. However, the data on distribution and excretion of IAA after ingestion by mammals are still scarce. Here, we developed a reliable and validated method for detecting IAA in biological specimens (plasma, urine, feces, liver, kidney, and tissues) based on modified QuEChERS sample preparation combined with gas chromatography-tandem triple quadrupole mass spectrometry (GC-MS/MS).

Physiologically based pharmacokinetic (PBPK) modeling of BDE-209 following oral exposure in Chinese population.

The wide usage of decabromodiphenyl ether (BDE-209) as additive brominated flame retardant has caused its widespread occurrence in the environment and high exposure risk in humans. Estimating its internal exposure dose and reconstruction of external exposure dose using physiologically based pharmacokinetic (PBPK) modelling approach is a key step in the risk assessment of BDE-209. However, the PBPK model for BDE-209 is currently unavailable.

Colorimetric detection uranyl ions based on the enhanced peroxidase-like activity by GO adsorption.

Based on the fact that uranyl ions (UO) adsorbed on GO can enhanced the peroxidase-like activity of graphene oxide (GO), a novel colorimetric strategy for visualizing quantitative determination of uranyl ions was established. The peroxidase-like activity of GO-UO nanocomposites was assessed by catalyzing HO oxidation of TMB to produce a distinct color reaction. A good linearity between the UO concentration and absorption at 652 nm was acquired in the range of 5.

DNA-AgNCs as a fluorescence turn-off probe for dual functional detection of HO and Fe(II) ions.

A novel fluorescence probe (DNA-AgNCs) was synthesized for dually detecting hydrogen peroxide (HO) and ferrous ion (Fe(II)) in water samples. The assay is carried out through a dramatic "turn-off" fluorescence response of AgNCs by hydroxyl radical (OH), which is produced when HO and Fe(II) are present simultaneously. Under the optimal conditions, the degree of fluorescence quenching of the DNA-AgNCs at 525 nm is linearly related to the concentration of HO in the range of 0.

Development of a solid phase microextraction-gas chromatography-mass spectrometry method for the determination of pentachlorophenol in human plasma using experimental design.

A new method, headspace solid-phase microextraction (HS-SPME) with in situ derivatization and gas chromatography-mass spectrometry (GC-MS), which was used for the determination of trace amount of pentachlorophenol (PCP) in human plasma was presented. The acetylation derivatization reaction was firstly optimized using a Doehlert design. Then a series of parameters relevant to the headspace SPME procedure, including fiber coating, extraction temperature, extraction time and salt addition, were optimized using a two-level full factorial design expanded further to a central composite design.