Publications by authors named "Dongliang Li"

The prognostic significance of the red blood cell distribution width to albumin ratio (RAR) spans various diseases, yet its utility as a biomarker for hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) remains unclear. We retrospectively studied 1,413 patients with HBV-HCC. Receiver operating characteristic curves identified optimal RAR cut-offs, stratifying patients into H-RAR and L-RAR groups.

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Energy deprivation and metabolic rewiring of cardiomyocytes are widely recognized hallmarks of heart failure. Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts of patients with dilated cardiomyopathy. Induced Hey2 expression in zebrafish hearts or mammalian cardiomyocytes impairs mitochondrial respiration, accompanied by elevated ROS, resulting in cardiomyocyte apoptosis and heart failure.

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Introduction: In order to enhance the quality of cigar tobacco leaves (CTLs), a gradient variable temperature fermentation approach was employed.

Methods: The temperature gradient demonstrated a gradual increase from low temperature (35 ± 2°C) to moderate temperature (45 ± 2°C), and then to high temperature (55 ± 2°C). Each temperature gradient underwent a 10-day fermentation process, resulting in a total duration of 30 days.

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Introduction: Fermentation is a crucial process in cigar manufacturing. Exogenous addition of functional microorganisms for fortified fermentation can further improve cigar tobacco leaves fermentation quality.

Methods: In this study, five strains were isolated from cigar tobacco leaves.

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Introduction: Fermentation plays a significant role in improving the quality of cigar tobacco leaves. Particularly, fermentation with characteristic additives has been identified as an effective approach to enhance the fermentation process. The objective of this study was to develop new additives and investigate their influence on cigar tobacco leaves.

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Purpose: This study investigates the clinical benefits of integrating traditional Chinese medicine (TCM) with Transarterial Chemoembolization (TACE) in hepatocellular carcinoma (HCC) treatment via meta-analysis and an exploration of network pharmacology analysis (NPA).

Methods: A comprehensive search across different databases retrieved all randomized controlled trials (RCTs) evaluating TCM combined with TACE for HCC. Meta-analysis included 39 RCTs to assess the intervention effects.

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Article Synopsis
  • Fermentation improves cigar tobacco quality by enhancing aromas and reducing irritancy through microbial metabolism.
  • A Rhodotorula strain (Rh3) that produces carotenoids was genetically modified to include a CCD1 gene, leading to significantly higher degradation products in fermentation.
  • The modified Rh3 strain increased carotenoid degradation by 65.9% during fermentation compared to the original strain's 41.4%, demonstrating potential for better cigar tobacco quality and efficient use of discarded leaves.
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Sustainable poly(lactic acid) (PLA)/poly(propylene carbonate) (PPC) blends were compatibilized by the environmentally friendly epoxidized soybean oil (ESO) through the chemical reaction of epoxy functional groups on ESO with the terminated carboxyl and hydroxyl groups of PLA/PPC. The compatibilization effect of ESO was confirmed by Fourier transform infrared spectroscopy, rheological property testing, differential scanning calorimetry, and morphological observations. It was revealed that the molecular chain entanglement between PLA and PPC was significantly enhanced and the dispersed PPC phase size was decreased, which endowed the blend with high viscosity modulus, low tan δ, and great stretchability, especially for the blend containing 1.

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Ester-producing strains are of great importance for enhancing the quality and flavor profiles of alcoholic beverages. However, traditional methods for screening ester-producing strains are labor-intensive and time-consuming, significantly impeding the development of alcoholic beverages industry. In this study, we selected five brands of Jiuqu to cultivate within different media, results showed that XB (Jiuqu) incubated with malt extract medium possessed the highest ester-producing capability, with the identification of 27 esters at the concentration of 31.

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To prevent the residual sulfur dioxide in Chinese herbal medicines (CHM) caused by sulfur fumigation, which may lead to severe health issues, there is an urgent need for a rapid and quantitative detection technique. Sodium borohydride was used as a reducing agent to convert sulfur dioxide into hydrogen sulfide, which was then detected using lead acetate test strip. An accurate testing apparatus was designed, consisting of reaction bottle cap, reaction bottle, lead acetate test strip, and sulfur dioxide detector.

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Hypertension is a major global health issue, contributing to significant cardiovascular morbidity and mortality. Mitochondrial dysfunction, particularly through dysregulated mitophagy, has been implicated in the pathogenesis of hypertension. We wanted to find out the relationship between mitochondrial autophagy and changes in arterial smooth muscle cell tension and the molecular mechanism.

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Article Synopsis
  • Regular monitoring of blood oxygen levels is crucial for preventing and treating diseases, and Image Photoplethysmography (IPPG) technology is a non-contact method used for this purpose.
  • Traditional IPPG devices face challenges like low accuracy and limited spectral range, prompting the need for improved methods.
  • This paper presents two new detection methods based on dual-wavelength measurements, demonstrating that the dual-band IPPG signal AC/DC method significantly reduces model training time and enhances non-contact blood oxygen measurement capabilities.
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  • The study aimed to evaluate how mixed probiotics affect lung microbial diversity in critically ill patients on mechanical ventilation.
  • A total of 24 patients were split into two groups: one received probiotics, while the other did not; their lung samples and blood were analyzed at specific intervals.
  • Results showed that while microbial diversity decreased in the control group, it remained stable in the probiotic group, suggesting probiotics may help maintain lung health during mechanical ventilation.*
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As the global population ages, the incidence of Parkinson's Disease (PD) continues to rise, imposing significant social and economic burdens. Mangiferin (MGF), a polyphenolic, bioactive compound has been shown to play a role in the prevention and treatment of PD. This study investigates the neuroprotective effects of MGF in an MPTP-induced zebrafish model of PD through transcriptome analysis.

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Background: Pseudorabies virus (PRV), a member of the family Herpesviridae, is responsible for significant economic losses in the pig industry and has recently been associated with human viral encephalitis, leading to severe neurological symptoms post-recovery. Despite the widespread impact of PRV, there are currently no approved effective drugs for treating PRV-related diseases in humans or pigs. Therefore, the exploration and discovery of safe and effective drugs for the prevention and treatment of PRV infection is of paramount importance.

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Article Synopsis
  • The study explores how different media and methods of adding those media impact the fermentation process of cigar tobacco leaves using a plant extract and a bacterial agent.
  • Results indicate that the order of addition matters, with the best approach being to first add plant extracts followed by microbial agents.
  • This method leads to a 46% reduction in cellulose and an increase in β-carotene, enhancing the aroma and overall quality of the tobacco while also changing the composition of the microbial community.
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Optofluidics, which utilizes the interactions between light and fluids to realize various functions, has garnered increasing attention owing to the advantages of operational simplicity, exceptional flexibility, rapid response, etc. As one of the typical light-fluid interactions, the localized photothermal effect serving as a stimulus has been widely used for fluid manipulation. Particularly, significant progress on photothermal-driven droplet manipulation has been made.

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Cigars, treasured for their rich aromatic profiles, occupy a notable segment in the global consumer market. The objective of this study was to characterize the volatile aroma compounds that shape the flavor profiles of six distinct varieties of Great Wall cigars, contributing to the understanding of cigar aroma analysis. Utilizing HS-GC-IMS and sensory evaluation, the study discerned the aroma profiles of GJ No.

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The jasmonic acid (JA) signaling pathway plays an important role in plant responses to abiotic stresses. The PEAPOD (PPD) and jasmonate ZIM-domain (JAZ) protein in the JA signaling pathway belong to the same family, but their functions in regulating plant defense against salt stress remain to be elucidated. Here, Gossypium arboreum PPD2 was overexpressed in Arabidopsis thaliana and systematically silenced in cotton for exploring its function in regulating plant defense to salt stress.

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The sudden change in the environment from a dark, low-oxygen, low-temperature, high-humidity underground stable environment to an environment with much-improved temperature and humidity, a high oxygen content, enhanced light exposure, and increased harmful organisms has greatly affected the stability of the ivory unearthed from the Sanxingdui site. Therefore, the implementation of an effective emergency protection strategy for ivory excavated at Sanxingdui is imperative and urgently needed. However, the current gauze technique used at many archaeological sites suffers from short timescales, poor transparency of the material, and susceptibility to reverse osmosis of the ivory.

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Introduction: Curing is a critical process that determines the sensory quality of cigars. The impact of oxygen on cigar curing and the mechanisms by which it regulates microbial changes affecting cigar quality are not well understood.

Methods: In this study, we selected handmade cigars from the same batch and conducted curing experiments in environments with varying oxygen concentrations (equivalent to 0.

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Environmental humidity profoundly influences various life activities, especially for plants that depend heavily on optimal humidity for growth. The humidity index is particularly crucial for preserving the functionality of plant leaves, notably in economically valuable plants such as cigar tobacco. This paper introduces a novel dual-layer moisturizing material, a PAS-PDMS composite, based on polyacrylamide/solketal (PAS) hydrogel and polydimethylsiloxane (PDMS).

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The real-time monitoring of low-concentration cytokines such as TNF-α in sweat can aid clinical physicians in assessing the severity of inflammation. The challenges associated with the collection and the presence of impurities can significantly impede the detection of proteins in sweat. This issue is addressed by incorporating a nanosphere array designed for automatic sweat transportation, coupled with a reusable sensor that employs a Nafion/aptamer-modified MoS field-effect transistor.

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Article Synopsis
  • - The study investigated the prevalence of the parasitic protozoan Giardia duodenalis in sheep and the environmental contamination on large-scale sheep farms in Henan and Ningxia, China, highlighting its significance in public health.
  • - A total of 528 fecal samples, 402 environmental samples, and 30 water samples were collected, revealing a G. duodenalis detection rate of 7.8% in fecal samples, 1.4% in environmental samples, and 23.3% in water samples, with higher infection rates among young lambs.
  • - Genetic analysis showed that G. duodenalis in the areas studied belonged to two assemblages, A and E, with assemblage E being
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