Novel Ru(II) Complexes as Type-I/-II Photosensitizers for Multimodal Hypoxia-Tolerant Chemo-Photodynamic/Immune Therapy.

Photodynamic therapy (PDT) is increasingly regarded as an attractive approach for cancer treatment due to its advantages of low invasiveness, minimal side effects, and high efficiency. Here, two novel Ru(II) complexes , were designed and synthesized by coordinating phenanthroline and biquinoline ligands with Ru(II) center, and their chemo-photodynamic therapy and immunotherapy were explored. Both and exhibited significant phototoxicity against A549 and 4T1 tumor cells type-I/-II PDT.

Development of Novel β-Carboline/Furylmalononitrile Hybrids as Type I/II Photosensitizers with Chemo-Photodynamic Therapy and Minimal Toxicity.

Chemo-photodynamic therapy is a treatment method that combines chemotherapy and photodynamic therapy and has demonstrated significant potential in cancer treatment. However, the development of chemo-photodynamic therapeutic agents with fewer side effects still poses a challenge. Herein, we designed and synthesized a novel series of β-carboline/furylmalononitrile hybrids - and evaluated their chemo-photodynamic therapeutic effects.

Research on structural strengthening technology for regenerative denitration catalysts.

The cost of replacing failed selective catalytic reduction (SCR) catalysts and their disposal as hazardous solid waste is high. If failed catalysts are recovered and regenerated into new SCR denitration catalysts, the cost of flue gas denitration can be effectively reduced. However, regenerated SCR catalysts have relatively low structural strength and activity and cannot yet form an effective replacement.

Precise tumor delineation in clinical tissues using a novel acidic tumor microenvironment activatable near-infrared fluorescent contrast agent.

Tumor selective near-infrared (NIR) fluorescent contrast agents has the potential to greatly enhance the efficiency and precision of tumor surgery by enabling real-time tumor margin identification for tumor resection guided by imaging. However, the development of these agents is still challenging. In this study, based on the acidic tumor microenvironment (TME), we designed and synthesized a novel pH-sensitive NIR fluorescent contrast agent OBD from β-carboline.

Rational design of β-carboline as an efficient type I/II photosensitizer to enable hypoxia-tolerant chemo-photodynamic therapy.

Photodynamic therapy (PDT) is a clinically approved treatment for cancer due to its high spatiotemporal selectivity and non-invasive modality. However, its therapeutic outcomes are always limited to the severe hypoxia environment of the solid tumor. Herein, two novel photosensitizers HY and HYM based on naturally antitumor alkaloids β-carboline were designed and synthesized.

Antibiotics can alter the bacterial extracellular polymeric substances and surface properties affecting the cotransport of bacteria and antibiotics in porous media.

Currently, studies on the environmental impact of antibiotics have focused on toxicity and resistance genes, and gaps exist in research on the effects of antibiotics entering the environment on bacterial surface properties and the synergistic transport of antibiotics and bacteria in porous media. To fill the gaps, we investigated the interactions between bacteria and antibiotics in synergistic transport in saturated porous media and the effects of media particle size, flow rate, and ionic concentration on this synergistic transport. This study revealed that although synergistic transport was complex, the mechanism of action was clear.

Combined effects of bacteria and antibiotics on surface properties and transport of nanoplastics in porous media.

Currently, research on the individual effects of bacteria and antibiotics on the transport of nanoplastics (NPs) in porous media is in its infancy, while research on their combined effect is absent. It is well known that bacteria and antibiotics also interact with each other, so this synergistic transport of bacteria, antibiotics, and NPs in porous media must be very interesting. For exploring this aspect, we investigated the individual and combined effects of bacteria and antibiotics on the transport of polystyrene NPs (PS-NPs) in saturated porous media.

The Use of Pyrolytic Char Derived from Waste Tires in the Removal of Malachite Green from Dyeing Wastewater.

The organic dye malachite green (MG) poses a potential risk of cancer and fertility loss in humans and aquatic organisms. This study focused on a modified pyrolytic char (PC) derived from waste tires to efficiently remove MG from wastewater. Modified PC has rich -OH functional groups, higher BET (Brunauer-Emmett-Teller) surfaces of 74.

Damage evolution and fracture behavior of different materials specimens containing a central hole subjected to local loading.

The strength of the different materials specimens containing a central hole subjected to varying loading areas constitutes lots of underground engineering such as entry arrangement and mining process. In this study, the failure resulted from micro-fracturing in the specimen, which can be characterized by the crack propagation path if the damage events are monitored by using Digital Image Correlation (DIC), infrared thermal imager and high-speed camera. The experimental results demonstrate that there are three different types of typical failure modes for specimens with central holes according to the loading areas.

Synthesis of CoFeO/Peanut Shell Powder Composites and the Associated Magnetic Solid Phase Extraction of Phenoxy Carboxylic Acid Herbicides in Water.

The magnetic biochar material CoFeO/PCPS (peanut shell powder) was prepared based on the hybrid calcination method. The properties of prepared composites and the extraction effect of magnetic solid phase extraction on phenoxy carboxylic acid herbicides were assessed. The morphology, crystal structure, specific surface area, and pore size distribution of the material were analysed using a transmission electron microscope (TEM), infrared Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and N absorption surface analysis (BET).

Magnetic Solid-Phase Extraction Based on Fe₃O₄/g-C₃N₄ Nanocomposite for the Determination of Polychlorinated Biphenyls and Polychlorinated Diphenyl Ethers in Environmental Waters.

The graphitic carbon nitride (g-C₃N₄) and the Fe₃O₄/g-C₃N₄ magnetic materials were synthesized in this paper. The structures of the materials were confirmed by a series of analysis. The Fe₃O₄/g-C₃N₄ was then used as a sorbent to adsorb polychlorinated diphenyl ethers and polychlorinated biphenyls.

Poloxamer 188-mediated anti-inflammatory effect rescues cognitive deficits in paraquat and maneb-induced mouse model of Parkinson's disease.

Mild cognitive impairment in Parkinson's disease (PD-MCI) is considered as a nonmotor clinical symptom in Parkinson's disease (PD). Microglia-mediated inflammation contributes to cognitive function impairment. Poloxamer 188 (P188) is an amphipathic polymer which has cytoprotective effect in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced dopaminergic (DA) neurons degeneration in PD.

Poloxamer 188 rescues MPTP-induced lysosomal membrane integrity impairment in cellular and mouse models of Parkinson's disease.

Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Rupture of lysosome is a major cellular stress condition leading to cell death in PD. We have previously shown that environmental oxidative toxins could impair autophagic flux and lysosomal functions in PD.

Enhancing adsorption efficiency of dichloroacetic acid onto mesoporous carbons: Procedure optimization, mechanism and characterization.

Highly ordered mesoporous carbon may be directly synthesized via supramolecular self-assembly with in situ evaporation-induced crystallization process by controlling thermal reaction temperatures and carbon mass loading. In the present study, the effects of thermal reaction temperatures on the structural characterization and adsorption capacity of mesoporous carbon have been investigated and analyzed with orthogonal test experiments. The results show the carbonization temperature (R=32.

[Effect of insulin by local injection on the level of systemic blood glucose and granulation tissue formation of wound in patients with diabetic foot ulcer].

Objective: To investigate the effects of local injection of insulin on the level of systemic blood glucose and granulation tissue formation of wound in patients with diabetic foot ulcer.

Methods: Thirty-two patients with diabetic foot ulcer hospitalized in our wards from June 2009 to June 2010 were divided into insulin (I, n = 16) and control (C, n = 16) groups according to the random number table. For patients in I group, after debridement, one half of calculated dose of insulin diluted with equal amount of normal saline was injected diffusely into the base of the ulcer, and another half dose of insulin was subcutaneously injected into abdominal wall for 7 days, two times a day.