Publications by authors named "Dongjie Qiu"
Background: Postoperative delirium (POD) is an acute brain dysfunction that mainly occurs in elderly patients after surgery. Postoperative pain is an important factor in the occurrence of POD, and effective pain management can reduce the risk of POD. Our study aims is to investigate the effect of ultrasound-guided femoral nerve block (FNB) on postoperative pain and the occurrence of POD after knee arthroplasty, and whether its mechanism is related to oxidative stress, inflammatory factors.
View Article and Find Full Text PDFObjectives: To evaluate the effects of ultrasound-guided thoracic paravertebral nerve block on perioperative pain and postoperative delirium in elderly patients undergoing thoracoscopic lobotomy.
Methods: Patients aged 60 to 80 years who underwent the surgery of thoracoscopic lobectomy were selected; ASA grades I to III and New York Heart Association (NYHA) grades I to II. Patients were randomly divided into two groups: group C (group Compaired) and group T (group Thoracic Paravertebral Nerve Block TPVB).
Paclitaxel is an effective chemotherapy drug for breast cancer (BC); however, drug resistance affects long-term clinical applications. In this study, we aimed to explore whether a natural compound, tetrahydrocurcumin (THC), could sensitize BC to albumin-bound paclitaxel (ab-PTX). The sensitization effect of THC to ab-PTX was evaluated in human BC cell lines, and chemosensitivity was measured using a xenograft BC tumor model.
View Article and Find Full Text PDFSecreted protein acidic and rich in cysteine (SPARC) plays a crucial role in the formation and progression of tumors. DNA methylation has become increasingly recognized as a frequent event of epigenetic alterations and one of the primary mechanisms of gene inactivation. The study aims to investigate the status of DNA methylation and the biofunction of SPARC in breast cancer.
View Article and Find Full Text PDFArticle Synopsis
- The study explores whether the depth of anesthesia impacts postoperative mortality, finding a significant correlation between low bispectral index (BIS) levels and increased mortality risk.
- Analysis included data from 38,722 patients, revealing that while low BIS is linked to higher mortality after cardiac surgery, the same association was not seen for other types of surgeries.
- The findings suggest that deep anesthesia could affect long-term mortality, particularly in cardiac surgery patients, but this effect diminished 30 days post-surgery.