Experimental and Theoretical Study on Surface Reactivity and CO Generation Mechanism of Bituminous Coal during Room-Temperature Oxidation.

To investigate the evolution of the microscopic chemical structure during the oxidation of bituminous coal at room temperature (25 °C) and infer the formation mechanism of carbon monoxide (CO), a self-designed closed-system coal oxidation experimental setup was employed to measure the CO generation from three bituminous coal samples [Duanwang (DW), Linsheng (LS), and Kunning (KN)]. C nuclear magnetic resonance and X-ray photoelectron spectroscopy were used to determine the structures and contents of different carbon atoms and surface elemental compositions and chemical states of the coal samples. Molecular models were constructed on the basis of the experimental data, and reactive force field pyrolysis simulation was used to trace the carbon atoms in the generated CO molecules.

SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation.

SIL1, an endoplasmic reticulum (ER)-resident protein, is reported to play a protective role in Alzheimer's disease (AD). However, the effect of SIL1 on amyloid precursor protein (APP) processing remains unclear. In this study, the role of SIL1 in APP processing was explored both and .

ICA1 affects APP processing through the PICK1-PKCα signaling pathway.

Aims: Islet cell autoantigen 1 (ICA1) is involved in autoimmune diseases and may affect synaptic plasticity as a neurotransmitter. Databases related to Alzheimer's disease (AD) have shown decreased ICA1 expression in patients with AD. However, the role of ICA1 in AD remains unclear.

Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.

Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), a key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defects through unknown mechanisms. In a patient with compound heterozygous mutations in Diphthamide Biosynthesis 1 (DPH1) and impaired eEF2 diphthamide modification, we observe multiple defects in neural crest (NC)-derived tissues.

Astrocyte-Ablation of Increases Anxiety-Like Behavior in Adult Male Mice.

Background: Astrocytes are essential for synaptic transmission, and their dysfunction can result in neuropsychiatric disorders such as anxiety and depression. Many studies have shown that global knockout of Melatonin receptor 2 () is associated with the development of various mental disorders.

Aim: This study aimed to investigate the effects of astrocyte ablation of on cognitive function and anxiety-like behavior in mice, as well as the potential biological mechanisms.

Spatio-temporal evolution law of gas-temperature coupling field in "110 method" goaf and prevention of spontaneous combustion.

To investigate the distribution characteristics of spontaneous combustion disaster (SCD) zones in the goaf of "110" mining method with U + L ventilation system and formulate corresponding fire prevention measures, enclosed coal oxidation experiments were carried out to measure the oxidation characteristics of Dongrong Coal Mine bituminous coal sample. A coupled 3DEC-CFD (3 dimensional Distinct Element Code) model was established. The 3D transient distribution characteristics of SCD zones in the "110" mining goaf under U+L ventilation condition were analyzed.

Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer's Disease.

Amyloid β protein (Aβ) is a critical factor in the pathogenesis of Alzheimer's disease (AD). Aβ induces apoptosis, and gasdermin-E (GSDME) expression can switch apoptosis to pyroptosis. In this study, we demonstrated that GSDME was highly expressed in the hippocampus of APP23/PS45 mouse models compared to that in age-matched wild-type mice.

PCP4 Promotes Alzheimer's Disease Pathogenesis by Affecting Amyloid-β Protein Precursor Processing.

Background: Down syndrome (DS) is caused by an extra copy of all or part of chromosome 21. The patients with DS develop typical Alzheimer's disease (AD) neuropathology, indicating the role of genes on human chromosome 21 (HSA21) in the pathogenesis of AD. Purkinje cell protein 4 (PCP4), also known as brain-specific protein 19, is a critical gene located on HSA21.

Smoke dispersion test and emergency control plan of fire in mine roadway during downward ventilation.

To explore the wind flow turbulence and smoke flow diffusion law during the mine downward ventilation fire, two similar experimental platforms of a inclined single pipe test device and a loop system multiple pipe test device were built. The change data of the air flow in the pipeline during the fire period under different air volumes were measured. The evolution process of downward ventilation fire in the whole roadway network domain in Dayan Mine was simulated, and the emergency plan was put forward.

Gallic acid inhibits neuroinflammation and reduces neonatal hypoxic-ischemic brain damages.

Neuroinflammation is a leading cause of secondary neuronal injury in neonatal hypoxic-ischemic encephalopathy (HIE). Regulation of neuroinflammation may be beneficial for treatment of HIE and its secondary complications. Gallic acid (GA) has been shown to have anti-inflammatory and antioxidant effects.

GPSAdb: a comprehensive web resource for interactive exploration of genetic perturbation RNA-seq datasets.

Gene knock-out/down methods are commonly used to explore the functions of genes of interest, but a database that systematically collects perturbed data is not available currently. Manual curation of all the available human cell line perturbed RNA-seq datasets enabled us to develop a comprehensive human perturbation database (GPSAdb, https://www.gpsadb.

Dynamic distribution and prevention of spontaneous combustion of coal in gob-side entry retaining goaf.

The 11101 working face of Qipanjing Mine was taken as the research object to explore the dynamic change law of the spontaneous combustion of the remaining coal in the gob-side entry retaining goaf area. A sealed oxygen consumption experiment was conducted to determine the (critical) oxygen volume fraction in the suffocation zone and continuous oxygen consumption rate of coal samples. The parameters of the working face were measured on site, and the air volume fraction in the goaf was monitored using a beam tube.

Chronic Alcohol Exposure Alters Gene Expression and Neurodegeneration Pathways in the Brain of Adult Mice.

Background: Chronic alcohol consumption can alter the structure of the central nervous system and disrupt cognitive function. Alcoholics are more likely to develop neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). However, the role of alcohol in promoting neurotoxicity and neurodegeneration remains unclear.

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia.

Increased endogenous hydrogen sulfide (HS) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. HS promotes angiogenesis, stimulates bioenergy metabolism and inhibits selective phosphatases. However, the role of CBS and HS in chronic myeloid leukemia (CML) remains elusive.

A novel de novo nonsense mutation in ZC4H2 causes Wieacker-Wolff Syndrome.

Background: Wieacker-Wolff syndrome (WWS) is a congenital X-linked neuromuscular disorder, which was firstly reported in 1985. Zinc finger C4H2-type containing (ZC4H2) gene has been found to be associated with the disease pathogenesis. However, the underlying mechanism remains elusive.