Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population.

Background: To explore the relationship of peroxiredoxin6 (PRDX6) tag-single nucleotide polymorphisms (SNPs) with susceptibility to chronic obstructive pulmonary disease (COPD) in the Chinese Han population.

Methods: A total of 502 patients with COPD and 481 healthy controls from nine hospitals in China were enrolled in this study. The PRDX6 tag-SNPs were identified by linkage disequilibrium (LD) analysis in 30 healthy controls.

Rational Design of Disulfide Bridges in PETase for Enhancing the Enzymatic Performance in PET Degradation.

Polyethylene terephthalate (PET) is one of the most prevalent transparent thermoplastics. It is commonly utilized due to its low cost and high durability. With the massive accumulation of waste PET, however, serious environmental pollution has become a global problem.

TRPV1 genetic polymorphisms and risk of COPD or COPD combined with PH in the Han Chinese population.

COPD is a common chronic disease with genetic predisposition. TRPV1 is mainly expressed in peripheral neuron which widely exists in entire respiratory tract. In present study, we aimed to study the relationship between single nucleotide polymorphisms (SNPs) of transient receptor potential vanilloid-1 (TRPV1) and the risk of chronic obstructive pulmonary disease (COPD) or COPD combined with pulmonary hypertension (PH) in Chinese Han population.

Puerarin Alleviates Lipopolysaccharide-Induced Myocardial Fibrosis by Inhibiting PARP-1 to Prevent HMGB1-Mediated TLR4-NF-κB Signaling Pathway.

Myocardial fibrosis (MFs) is a crucial pathological process that results in cardiac failure in the development of multiple cardiovascular diseases. Puerarin could reportedly be used to treat a variety of cardiovascular diseases. However, the exact mechanism of puerarin on MFs was not clear enough.

Fault reactivation and earthquakes with magnitudes of up to Mw4.7 induced by shale-gas hydraulic fracturing in Sichuan Basin, China.

This paper presents a timely and detailed study of significant injection-induced seismicity recently observed in the Sichuan Basin, China, where shale-gas hydraulic fracturing has been initiated and the aggressive production of shale gas is planned for the coming years. Multiple lines of evidence, including an epidemic-type aftershock sequence model, relocated hypocenters, the mechanisms of 13 large events (M  > 3.5), and numerically calculated Coulomb failure stress results, convincingly suggest that a series of earthquakes with moment magnitudes up to M 4.

Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.

Objective: Sepsis is an inflammatory syndrome caused by infection, and both its incidence and mortality are high. Because interferon-gamma (IFN-γ) plays an important role in inflammation, this work assessed IFN-γ single nucleotide polymorphism (SNPs) that may be associated with sepsis.

Methods: A total of 196 patients with pneumonia-induced sepsis and 213 age- and sex-matched healthy volunteers participated in our study from July 2012 to July 2013 in Guangzhou, China.

[Distribution and drug resistance profiles of pathogenic bacteria isolated from patients with nosocomial infection in intensive care unit].

Objective: To investigate the distribution and drug sensitivity of pathogenic bacteria isolated from patients with nosocomial infection in intensive care unit.

Methods: The clinical data were collected from 229 hospitalized patients with nosocomial infection in intensive care unit from 2009 to 2011.

Results: Gram-negative bacteria were the main pathogens (68.

[Clinical outcomes and characteristics of concurrent eclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome].

Objective: the purpose was to describe the outcomes and characteristics of the obstetric patients with concurrent eclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP) syndrome.

Methods: we retrospectively collected the materials between December 1999 and December 2008 in Obstetric Critical Care Center of Guangzhou. There were 76 patients in rolled then they were divided into two groups according to with or without HELLP syndrome.

[Establishment of a neonatal piglet model of multiple organ dysfunction syndrome].

Objective: To study the reliability of establishing a neonatal piglet model of multiple organ dysfunction syndrome (MODS) by cecal ligation and puncture (CLP).

Methods: Fourteen neonatal piglets were randomly assigned into Experiment group (n=9) and Control group (n=5). MODS model was established in the piglets from the Experiment group by CLP.