Publications by authors named "Donghyeon Lim"
Article Synopsis
- - The study focuses on developing an adverse outcome pathway (AOP) for humidifier disinfectant (HD) substances in South Korea, utilizing in vitro data to assess their health risks and establish dose-response relationships.
- - Researchers analyzed 193 sets of toxicological data from published studies on HD substances and evaluated the risk of bias, estimating benchmark doses (BMD) for different toxicity endpoints using EPA software.
- - Key findings revealed that certain HD substances, like PHMG-p and CMIT/MIT, induce critical biological effects such as ATP depletion and oxidative stress, potentially leading to severe health issues, thus aiding in more informed risk assessments for these chemicals.
Dodecamethylcyclohexasiloxane (D6) is a siloxane substance mainly used in cosmetics and personal care products. While octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) were once commonly used in personal care products, their usage has been restricted due to the classification as persistent, bioaccumulative, and toxic (PBT)/very persistent and very bio-accumulative (vPvB) substances. While D6 has emerged as a substitute for D4 and D5, the risk assessment for D6 remains limited compared to the evaluations for D4 and D5.
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