Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma.

Long noncoding RNAs (lncRNAs) crucially modulate DNA damage responses/repair in cancer cells. However, the underlying regulatory role of genome integrity and its clinical value in colon adenocarcinoma (COAD) remains unclear. This study links genome instability to lncRNA using computational biology techniques, in attempt to propose novel biomarkers of immunotherapy outcome, and investigated a potential competing endogenous RNA (ceRNA) as a molecular regulatory mechanism.

[Longitudinal Study of the Association Between Handgrip Strength and Chronic Disease Multimorbidity among Middle-aged and Older Adults].

Objective: To investigate the potential association between multimorbidity and the handgrip strength of middle-aged and older adults.

Methods: The baseline (2011) and second-round follow-up (2015) data of China Health and Retirement Longitudinal Study (CHARLS) were used. Adults≥40 were selected as the subjects of the study.

[A Study of the Relationship Between Job Satisfaction and Work Engagement of Physicians in Public Hospitals].

Objective: To understand the level of job satisfaction and work engagement of physicians in public hospitals, to analyze the interaction between job satisfaction and work engagement, and to discuss how each dimension of job satisfaction affects work engagement so as to provide information and reference for improving the level of work engagement of physicians in public hospitals.

Methods: Covering 6 public hospitals in Sichuan (3 tertiary-level hospitals and 3 secondary-level hospitals), 638 questionnaires were obtained from physicians through convenient sampling for data description and analysis. Pearson correlation method was used to analyze the correlation between job satisfaction and work engagement, and multiple linear stepwise regression method was used to analyze work engagement and the influencing factors of each dimension.

[Applacation of portable energy-dispersive X-ray fluorescence spectrometer in chemical composition analysis of Chinese ancient glass].

Chemical composition is one of the most important aspects in the study of Chinese ancient glasses, as it could provide scientific proofs for the technical origin and development of Chinese ancient glasses. It is very necessary to find out some new an alyzing techniques. One of the most remarkable advantages for portable X-ray fluorescence technique is its portability, which allows antiques that can't be allowed to move out of museum to be analyzed.

Prevalence of human papillomavirus infection among women with and without normal cervical histology in Shandong Province, China.

Objective: The purpose of this study was to investigate the prevalence of human papillomavirus (HPV) genotypes infection in women with and with normal cervical histology in the littoral region of Shandong, China.

Methods: Scrape specimens were collected from 4,601 women for Pap smear and HPV genotypes identification. 1,489 women without normal cytology or with cervical disease were referred for colposcopic examination and biopsy procedures.

Spectroscopic, and thermal studies of some new binuclear transition metal(II) complexes with hydrazone ligands containing acetoacetanilide and isoxazole.

A new chelating ligand, 2-(2-(5-tert-butylisoxazol-3-yl)hydrazono)-N-(2,4-dimethylphenyl)-3-oxobutanamide (HL), and its four binuclear transition metal complexes, M(2)(L)(2) (micro-OCH(3))(2) [M=Ni(II), Co(II), Cu(II), Zn(II)], were synthesized using the procedure of diazotization, coupling and metallization. Their structures were postulated based on elemental analysis, (1)H NMR, MALDI-MS, FT-IR spectra and UV-vis electronic absorption spectra. Smooth films of these complexes on K9 glass substrates were prepared using the spin-coating method and their absorption properties were evaluated.

Synthesis, spectral, and thermal characterizations of Ni(II) and Cu(II) beta-diketone complexes with thenoyltrifluoroacetone ligand.

Two kinds of nickel(II) and copper(II) beta-diketone complexes derived from thenoyltrifluoroacetone ligand with blue-violet light absorption were synthesized by reacting free ligand and different metal(II) ions in sodium methoxide solution. Their structures were postulated based on elemental analysis, ESI-MS, FT-IR spectra and UV-vis electronic absorption spectra. Smooth films on K9 glass substrates were prepared using the spin-coating method.

[Ester derivatives of tetracyanoquinodimethane and their CT complexes: synthesis and studies by infrared spectroscopy].

Three ester derivatives of tetracyanoquinodimethane and their CT complexes were synthesized and characterized by elementary analysis and infrared spectra. The principal infrared absorption peaks were assigned and discussed for the region of 4000-400 cm(-1). Principal factors affecting principal infrared absorption were analyzed.

[Study on the spectral properties of a new fluorene derivative].

A new big pi-conjugated, symmetrical fluorene derivative, 9, 9-bis(2-ethylhexyl)-2,7-bis(2-(4-methoxy) benzene-2, 1-ethenyl) fluorene (abbreviated as MO-Flu-MO) was synthesized and characterized by elemental analysis, mass spectral, UV-Vis and IR spectral. Spectral characteristics of this compound, including linear absorption spectral and one-photon fluorescence spectral, were measured in acetonitrile, methylene chloride, tetrahydrofuran and hexane at room temperature. It was found that solvent effects have different influence on absorption spectral and fluorescence spectral, major reasons of such spectral behavior are discussed.

Spectroscopic and thermal properties of short wavelength metal (II) complexes containing alpha-isoxazolylazo-beta-diketones as co-ligands.

Two new azo dyes of alpha-isoxazolylazo-beta-diketones and their Ni(II) and Cu(II) complexes with blue-violet light wavelength were synthesized using a coupling component, different diazo components and metal (II) ions (Ni2+ and Cu2+). Based on the elemental analysis, MS spectra and FT-IR spectral analyses, azo dyes were unequivocally shown to exist as hydrazoketo and azoenol forms which were respectively obtained from the solution forms and from the solid forms. The action of sodium methoxide (NaOMe) on azo dyes in solutions converts hydrazoketo form into azoenol form, so azo dyes are coordinated with metal (II) ions as co-ligands in the azoenol forms.

[Spectroscopy of alpha-isoxazoleazoxyl-beta-diketone derivatives and their tautomers].

In this paper, the IR and UV-Vis spectroscopy of five novel alpha-isoxazoleazoxyl-beta-diketone derivatives with different structures have been studied, and their keto-enol and azo-hydrazone tautomeric phenomena have been discussed. It was found that all compounds, which are in the solid or in the solution, exist in the form of hydrazodiketo and azoenol isomers. The authors can also see that there are two absorption bands which are in the range 246-262 nm and 326-339 nm, respectively, for all compounds in the UV spectra, and the intensities of long wavelength absorption bands which are attributed to azoenol forms are stronger than short wavelength absorption bands which are attributed to hydrazodiketo forms.