Publications by authors named "Dongge Xu"
Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18.
J Immunother Cancer
December 2024
Article Synopsis
- Interleukin-18 (IL-18) enhances immune responses, but its clinical use is limited by a decoy receptor; to overcome this, researchers developed a variant called DR18 that doesn't bind to IL-18 binding protein.
- They tested this DR18 variant using an oncolytic adenovirus (oAdDR18) in mouse models of different tumors to see its effects on tumor growth and immune response.
- Results showed that oAdDR18 led to significant tumor growth reduction and enhanced immune cell infiltration compared to other forms of IL-18, indicating strong potential for treating cancers and reducing metastasis.
Article Synopsis
- Lymphotoxin α (LTα) is a substance produced by active lymphocytes that can kill tumor cells, but its clinical use has been limited due to instability and systemic toxicity.
- Researchers developed a mutant form of LTα (LTα Q107E) that specifically targets the TNFR1 receptor and demonstrated its effectiveness in promoting antitumor activity.
- An experimental oncolytic adenovirus carrying this LTα mutant (oAdQ2) was tested in mouse models and showed reduced tumor growth and increased infiltration of immune cells, suggesting improved therapeutic potential for cancer treatment.
Article Synopsis
- Long Interspersed Element 1 (L1) plays a crucial role in regulating the genome and evolution, and its expression is influenced by viral infections, affecting the host's immune response and disease progression.
- In the context of Epstein-Barr virus (EBV) and gastric cancer, research shows that EBV-associated gastric cancer (EBVaGC) exhibits decreased L1 transcription compared to EBV-negative gastric cancer (EBVnGC), particularly affecting young and full-length L1s (FL-L1s).
- The study suggests that increased H3K9me3 levels, linked to heightened TASOR expression, contribute to the repression of FL-L1s, demonstrating how EBV infection can reshape chromatin structure and
Article Synopsis
- * The study revealed that GA effectively hinders SARS-CoV-2 infection by blocking the virus's ability to attach to host cells via its spike (S) protein.
- * Analysis indicated that GA binds to specific sites on the S protein, preventing it from interacting with ACE2, the receptor needed for viral entry into cells.
Article Synopsis
- Adenoviral DNA is frequently found in tonsil specimens from children who undergo adenotonsillectomy, suggesting the virus remains in a latent state.
- In a study of 81 patients, 85.2% of the tonsil samples tested positive for human adenovirus (HAdV), revealing a link between specific tonsil microbiota profiles and the presence of the virus.
- The research indicates that certain bacteria and short-chain fatty acids present in the tonsils may contribute to the reactivation of HAdV, potentially leading to respiratory infections, particularly in children and organ transplant recipients.
Article Synopsis
- - This paper tackles the difficulties in identifying chemical components in herbs using mass spectrometry due to the absence of standard compounds, particularly for similar structures known as position isomers.
- - A new approach is proposed that leverages a self-feedback network of mass spectrometry data to identify and classify chemical constituents from herbs without needing reference compounds, creating a primary network of ions connected by selected bridging ions.
- - Using Picrasma quassioides as a case study, the study demonstrates that once a specific alkaloid is identified, the network can help deduce the structures and relationships of unknown compounds and their isomers through their connections to known diagnostic ions.