Publications by authors named "Dongge Qiao"
Article Synopsis
- Oxidative stress, ER stress, and neuronal apoptosis are key factors in brain injury after intracerebral hemorrhage (ICH), and chrysophanol (CHR) exhibits neuroprotective effects, although its specific role in ICH is still not fully understood.
- In a study using hemin-treated HT22 cells to simulate ICH, CHR treatment improved cell viability and reduced apoptosis, ER stress, and oxidative stress through various laboratory techniques such as CCK-8 and TUNEL staining.
- The underlying mechanism revealed that CHR regulates the miR-320-5p/Wnt3a pathway, activating the β-catenin pathway, which helps prevent cell damage, indicating that CHR may be a potential treatment
Background: To explore the mechanisms of raw rhubarb and wine-processed rhubarb treatment in a rat model of intracerebral hemorrhage (ICH).
Methods: After adapting to their environment, 30 male Wistar rats were divided into 5 treatment groups: blank control group (CK) (normal saline), sham operation group (SICH) (normal saline), ICH model group (ICH) (normal saline), ICH + raw rhubarb enema group (RO) (raw rhubarb 3.60 g/kg), and ICH + wine-processed rhubarb enema group (WRO) (wine-processed rhubarb 3.