Dissecting the Origin of Breast Cancer Subtype Stem Cell and the Potential Mechanism of Malignant Transformation.

Background: Breast cancer is the most common incident form of cancer in women including different subtypes. Cancer stem cells (CSCs) have been confirmed to exist in breast cancer. But the research on the origin of breast cancer subtype stem cells (BCSSCs) is still inadequate.

Association of JARID2 polymorphisms with non-syndromic orofacial clefts in northern Chinese Han population.

Objectives: Non-syndromic orofacial clefts (NSOC) are the most common human craniofacial malformation in all worldwide populations. Recently, the jumoji AT-rich interaction domain 2 (JARID2) had been reported to be a novel candidate gene for non-syndromic cleft lip with or without cleft palate (CL/P). The SNPs rs2076056, rs2237138 and rs2299043 in JARID2 were highly significant in Italian families.

bFGF-induced human periodontal ligament fibroblasts proliferation through T-type voltage-dependent calcium channels.

Objective: To test the hypothesis that T-type voltage-dependent calcium channels (T-CaCNs) are involved in basic fibroblast growth factor (bFGF)-induced proliferation of human periodontal ligament fibroblasts (HPLFs).

Materials And Methods: This study examined the expression of the T-type calcium channel sub-units Ca(V) 3.1, Ca(V) 3.

Nifedipine regulated periodontal ligament remodeling: an experimental study in rats.

Objective: The aim of this study was to investigate the effects of nifedipine on periodontal ligament remodeling during orthodontic tooth movement.

Material And Methods: Sixty male Sprague-Dawley rats were randomly divided into an orthodontic group and groups that received either 10 mg/kg or 40 mg/kg nifedipine (NIF). Immunohistochemical staining and image analysis were used to investigate the expression of matrix metalloproteinase (MMP)-1, -10, -13 and collagen-I in PDL, and maxillary 1st molar displacement was measured.