Publications by authors named "Dongdong Ai"

Vaginal myiasis is one of the most serious parasitic diseases in Bactrian camels. At present, there are no reports on biological control measures of the disease. In this paper, the metabolomic analysis of vaginal secretions from susceptible and non-susceptible camels was performed by ACQUITY UPLC H-Class Ultra Performance Liquid Chromatograph.

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Article Synopsis
  • Genital myiasis is a serious condition in Bactrian camels that can damage vaginal tissue and disrupt health and reproductive capabilities due to bacterial accumulation.
  • This study analyzed the vaginal microbiota of healthy camels versus those infected with genital myiasis, using advanced sequencing technology, which revealed that infected camels had higher microbial diversity and lower vaginal pH.
  • The research concluded that there are both differences and stability in the vaginal flora of Bactrian camels depending on their health status, providing insights into the bacteria associated with genital myiasis.
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The results of our previous study revealed that microRNA (miRNA/miR)-4530 was upregulated in the serum of patients with diabetic retinopathy. The TargetScan miRNA database was used to identify potential targets of miR-4530 and vasohibin-1 (VASH1) was predicted as one of the targets. The results of our previous study demonstrated that miR-4530 was able to promote angiogenesis in human umbilical vein endothelial cells.

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The identification of disease-specific alterations in miRNA expression and the ability to detect miRNAs in serum furnish the basis for identified potential research value. This study was aimed to characterize the expression of miRNAs in the serum samples from people with type 2 diabetes mellitus (T2DM) and healthy individuals in order to detect the differential expression of miRNAs in T2DM. In total, 582 participants were recruited.

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Astrocytes play multiple roles in physiological and pathological conditions in brain. However, little is known about the alterations of astrocytes in age-related changes, and few aging models of the astrocytes in vitro have been established. Therefore, in the present study, we used d-galactose (D-Gal) to establish astrocyte aging model to explore the alterations of astrocytes in brain aging.

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