Lenvatinib‑based treatment regimens in conversion therapy of unresectable hepatocellular carcinoma: A systematic review and meta‑analysis.

Hepatocellular carcinoma (HCC) is a malignancy associated with high morbidity and mortality rates. Conversion therapy provides patients with unresectable HCC (uHCC) the opportunity to undergo radical treatment and achieve long-term survival. Despite accumulating evidence regarding the efficacy of conversion therapy, the optimal treatment approach for such therapy remains uncertain.

Association of sarcopenia with liver fibrosis and steatohepatitis in non-alcoholic fatty liver disease: protocol for a systematic review and meta-analysis.

Introduction: Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder over the last four decades, more evidence shows a high prevalence of sarcopenia in NAFLD that may influence disease severity. This meta-analysis aims to determine the association of sarcopenia with liver fibrosis and steatohepatitis in NAFLD.

Methods And Analysis: We will conduct the literature search using Medline (via PubMed), Web of Science databases, EMBASE, Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews (from the date of inception to 1 May 2022).

Feasibility and safety of trans-biliary cryoablation: Preclinical evaluation of a novel flexible cryoprobe.

Cryoablation, as a well-characterized technology, has multifarious clinical applications in solid malignancy. However, trans-biliary cryoablation for malignant biliary obstruction has not been reported yet. Thus, this study aimed to determine the efficacy and safety of trans-biliary cryoablation with a novel CO gas-based flexible cryoprobe in standardized preclinical settings.

Clinical prognosis of intraoperative blood salvage autotransfusion in liver transplantation for hepatocellular carcinoma: A systematic review and meta-analysis.

Background: Intraoperative blood salvage autotransfusion(IBSA) has been widely used in a variety of surgeries, but the use of IBSA in hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT) is controversial. Numerous studies have reported that IBSA used during LT for HCC is not associated with adverse oncologic outcomes. This systematic review and meta-analysis aims to estimate the clinical prognosis of IBSA for patients with H+CC undergoing LT.

DHRS7 is an immune-related prognostic biomarker of KIRC and pan-cancer.

Renal clear cell carcinoma (KIRC) is one malignancy whose development and prognosis have been associated with aberrant DHRS7 expression. However, the catalytic activity and pathophysiology of KIRC are poorly understood, and no sensitive tumor biomarkers have yet been discovered. In our study, we examined the significant influence of DHRS7 on the tumor microenvironment (TME) and tumor progression using an overall predictable and prognostic evaluation approach.

Functions of CXC chemokines as biomarkers and potential therapeutic targets in the hepatocellular carcinoma microenvironment.

Background: Several studies have indicated that CXC chemokines influence the prognosis and therapy in patients with hepatocellular carcinoma (HCC). However, there are limited studies on the roles of CXC chemokines in HCC based on data acquired from various databases. This study aimed to conduct an in-depth and comprehensive bioinformatic analysis of the expression and functions of CXC chemokines in HCC.

Predicting infected pancreatic necrosis based on influential factors among the most common types of acute pancreatitis: a retrospective cohort study.

Background: Biliary and hypertriglyceridemic acute pancreatitis (BAP and HTGAP) are two of the leading etiologies in China. Infected pancreatic necrosis (IPN) is a particular and noticeable condition in the late stage of these diseases; however, the influential correlated factors on IPN and how to predict IPN are unclear.

Methods: In this retrospective study, 1,116 patients whose diagnosis was BAP or HTGAP met the inclusion criteria among 1,746 enrolled cases.

Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders.

Ras-related C3 botulinum toxin substrate 1 (Rac1) is a small GTPase that is well known for its sensitivity to the environmental stress of a cell or an organism. It senses the external signals which are transmitted from membrane-bound receptors and induces downstream signaling cascades to exert its physiological functions. Rac1 is an important regulator of a variety of cellular processes, such as cytoskeletal organization, generation of oxidative products, and gene expression.

Simultaneous resection of colorectal cancer and synchronous liver metastases is safe for properly selected elderly patients: A retrospective study.

Purpose: The present study was conducted to evaluate the efficacy and safety of simultaneous resection of colorectal cancer (CRC) and synchronous liver metastases (SCRLM) in a group of elderly Chinese patients regarding the population aging in China.

Methods: From January 1st 2010 to May 1st 2015, 24 out of 32 elderly patients who underwent simultaneous resection of CRC and SCRLM were matched with 24 out of 55 young patients based on the propensity scores. Perioperative results and survival outcomes were compared.

Efficient extraction of antimony(III) by titanate nanosheets: Study on adsorption behavior and mechanism.

Antimony has been listed as a critical pollutant in many countries because of its toxic effects on earth organisms. In this study, titanate nanosheets (TNS) were prepared with a high specific surface area by alkaline hydrothermal method. The adsorption mechanism and adsorption capacity of removing Sb(III) from aqueous solutions with TNS as an adsorbent were investigated for the first time.

A Prognostic Nomogram Based on Immune Scores Predicts Postoperative Survival for Patients with Hepatocellular Carcinoma.

Background: Increasing research attention has focused on tumor-infiltrating immune cells. However, the threshold of an immune score for use in predicting overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) is not defined. This study aims at exploring the association between immune scores with prognosis and building a clinical nomogram for predicting the survival of HCC patients.

Highly selective anchoring silver nanoclusters on MOF/SOF heterostructured framework for efficient adsorption of radioactive iodine from aqueous solution.

A series of Ag-modified MOF/SOF heterostructured framework adsorbents (Ag-MSHC) with strong binding of iodine were prepared by anchoring silver nanoclusters on MOF/SOF heterostructured framework (MSHC). Morphological transformation process of six novel Ag-MSHC adsorbents can be realized by tailoring the molar ratio of Fe, TMA (1,3,5-Tricarboxybenzen) and MA (melamine), finally resulting in a combination of MOFs (metal-organic frameworks) and SOFs (supramolecular organic framework). Among six adsorbents, Ag-MSHC-6 exhibited an extremely strong affinity towards I, whereas the maximum adsorption capacity of I reaches 771.

Efficient removal of uranium using a melamine/trimesic acid-modified hydrothermal carbon-based supramolecular organic framework.

In this study, we prepared a hydrothermal carbon-based supramolecular organic framework (HTC-MA-TMA) by grafting melamine and trimesic acid on hydrothermal carbon (HTC) for efficient removal of U (VI) from aqueous solutions. The nano-sized supramolecular organic framework (SOF) particles consisted of N-donor-containing melamine and O-donor-containing trimesic acid self-assembled through hydrogen bonds. Their large number of specific active sites acted as the immobilization center for capturing U (VI).

Degradation of Rhodamine B Under Visible-Light by Cu-Doped ZnAl Layered Double Hydroxide.

The Cu-doped ZnAl layered double hydroxides (LDH) were papered by coprecipitation. The prepared samples were characterized by mutiple techniques including X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) surface area, scanning electronic microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and UV-vis diffuse-reflectance spectroscopy (UV-vis DRS). The doping of Cu into the LDH sheets results in formation of the distorted CuO6 octahedrons which contribute for the excitation of electrons under visible light.

Improved Visible-Light-Induced Photocatalytic Performance of ZnAl Layered Double Hydroxide by Incorporation of Ni.

NiZnAl layered double hydroxides (LDH) with Ni/Zn/Al ratios ranging from 0.1/2/1 to 1/2/1 were papered by coprecipitation. The prepared samples were characterized by multiple techniques including X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) surface area, scanning electronic microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and UV-vis diffuse-reflectance spectroscopy (UV-vis DRS).

Epidermal expression of a sterol biosynthesis gene regulates root growth by a non-cell-autonomous mechanism in .

The epidermis is hypothesized to play a signalling role during plant development. One class of mutants showing defects in signal transduction and radial patterning are those in sterol biosynthesis. The expectation is that living cells require sterols, but it is not clear that all cell types express sterol biosynthesis genes.

Risk factors for bile leakage after primary closure following laparoscopic common bile duct exploration: a retrospective cohort study.

Background: Primary closure following laparoscopic common bile duct exploration (LCBDE) has been widely adopted because of the efficacy and safety in treatment of common bile duct (CBD) stones. However, the risk factors for bile leakage, the most common complication after primary closure, has not been clarified yet.

Methods: A retrospective cohort study of patients who underwent LCBDE with primary closure after choledochotomy between Feb.

Coffee and caffeine intake and risk of urinary incontinence: a meta-analysis of observational studies.

Background: Previous results from studies on the relationship between coffee/caffeine consumption and risk of urinary incontinence (UI) are inconclusive. We aim to assess this association using a meta-analysis of observational studies.

Methods: Pertinent studies were identified by searching electronic database (Embase, PubMed and Web of Science) and carefully reviewing the reference lists of pertinent articles until July 2015.

Intraductal papillary mucinous neoplasms of the pancreas: diagnosis and management.

Intraductal papillary mucinous neoplasms (IPMNs), characterized by intraductal papillary growth and thick mucin secretion, have increasingly been recognized. Despite modern preoperative evaluation, major difficulties still remain in distinguishing malignant invasive types from benign IPMNs. Following a PubMed database search, all relevant abstracts and articles on IPMN published in English and Chinese were reviewed.

[Comparison between primary anastomosis after intraoperative colonic defecation and Hartmann procedure in patients with obstructive left colon cancer].

Objective: To compare primary anastomosis after intraoperative colonic defecation and Hartmann procedure for obstructive left colon cancer.

Methods: Clinical data of 68 patients who underwent emergent laparotomy for left colon cancer with acute bowel obstruction between January 2000 and January 2008 were analyzed retrospectively.

Results: Primary resection and anastomosis with intraoperative defecation was performed in 43 patients and Hartmann's procedure in 25 cases.

Radiofrequency ablation combined with transarterial chemoembolization for unresectable primary liver cancer.

Background: Radiofrequency ablation (RFA) followed by transarterial chemoembolization (TACE) for unresectable primary liver cancer (PLC) has not been widely discussed. In this study, the outcome of the combination of RFA with TACE was retrospectively evaluated.

Methods: From May 2003 to March 2008, 127 consecutive PLC patients with a median age of 56.