RAMP: response-aware multi-task learning with contrastive regularization for cancer drug response prediction.

The accurate prediction of cancer drug sensitivity according to the multiomics profiles of individual patients is crucial for precision cancer medicine. However, the development of prediction models has been challenged by the complex crosstalk of input features and the resistance-dominant drug response information contained in public databases. In this study, we propose a novel multidrug response prediction framework, response-aware multitask prediction (RAMP), via a Bayesian neural network and restrict it by soft-supervised contrastive regularization.

Object-based correspondence effects for action-relevant and surface-property judgments with keypress responses: evidence for a basis in spatial coding.

It has been proposed that grasping affordances produce a Simon-type correspondence effect for left-right keypress responses and the location of the graspable part of an object for judgments based on action-relevant properties such as shape, but not on surface properties. We tested the implications of this grasping affordance account and contrasted them with the ones derived from a spatial coding account that distinguishes holistic processing of integral dimensions and analytic processing of separable dimensions. In Experiments 1-3, judgments about the color of a door handle showed a Simon effect relative to the handle's base, whereas judgments about the handle's shape showed no Simon effect.

Correspondence effects for objects with opposing left and right protrusions.

Choice reactions to a property of an object stimulus are often faster when the location of a graspable part of the object corresponds with the location of a keypress response than when it does not, a phenomenon called the object-based Simon effect. Experiments 1-3 examined this effect for variants of teapot stimuli that were oriented to the left or right. Whether keypress responses were made with fingers within the same hand or between different hands was also manipulated.

The object-based Simon effect: grasping affordance or relative location of the graspable part?

Reaction time is often shorter when the irrelevant graspable handle of an object corresponds with the location of a keypress response to the relevant attribute than when it does not. This object-based Simon effect has been attributed to an affordance for grasping the handle with the hand to the same side. Because a grasping affordance should differentially affect keypress responses only when they are made with different hands, we conducted three experiments that measured the object-based Simon effect for frying pan stimuli using between- and within-hand response sets.