Publications by authors named "DongZhi Zhuo-Ma"
Evaluation of nanoscaled dual targeting drug-loaded liposomes on inhibiting vasculogenic mimicry channels of brain glioma.
Artif Cells Nanomed Biotechnol
December 2021
Brain glioma is the most common primary tumour of the central nervous system. Complete surgical removal of the brain glioma is virtually impossible. Chemotherapy is still an important treatment for brain glioma.
View Article and Find Full Text PDFInhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.
Artif Cells Nanomed Biotechnol
December 2019
Article Synopsis
- Lung cancer is caused by uncontrolled growth of cells in the lungs, which can spread to other parts of the body through metastasis.
- Researchers developed a new treatment using DQA-modified paclitaxel and ligustrazine micelles to target and destroy vasculogenic mimicry (VM) channels, thereby inhibiting tumor metastasis.
- The study showed that these micelles effectively accumulated in tumor sites, demonstrated strong anti-cancer effects on A549 cells, and had minimal toxicity, suggesting a promising new strategy for treating non-small cell lung cancer (NSCLC).
[Multi-component quantitative analysis combined with chromatographic fingerprint for quality assessment of Onosma hookeri].
Zhongguo Zhong Yao Za Zhi
November 2015
Article Synopsis
- The study developed a method to simultaneously measure shikonin, acetyl shikonin, and β,β'-dimethylpropene shikonin in Onosma hookeri using HPLC-DAD with a specific gradient elution technique.
- Quality assessment of seven batches revealed significant variability in the three naphthoquinone constituents, with fingerprint analysis categorizing the samples into four distinct groups based on their similarity values.
- The findings suggest the complexity and inconsistency in the use of this medicinal plant, while the established HPLC fingerprints and quantitative analysis can effectively assess its quality.
Dried herb of Delphinium brunonianum Royle (Ranunculaceae) has long been used under the herbal name "Xiaguobei" (Delphinii Brunoniani Herba) in traditional Tibetan medicine and prescribed for the treatment of influenza, itchy skin rash and snake bites. In order to find a useful and convenient method for the identification of microscopic features, the technique of fluorescence microscopy was applied to authenticate "Xiaguobei" of Tibet. The transverse sections of stem and leaf, as well as the powder of "Xiaguobei" were observed to seek for typical microscopic features by normal light and fluorescence microscopy.
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