Publications by authors named "DongXia Fan"
Background: The growing consensus links exposure to fine particulate matter (PM) with an increased risk of respiratory diseases. However, little is known about the additional effects of particulate matter on brainstem function in allergic rhinitis (AR). Furthermore, it is unknown to what extent the PM-induced effects in the brainstem affect the inflammatory response in AR.
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- - Air pollution, especially fine particulate matter (PM), is harmful to human health, contributing to issues like insulin resistance and metabolic disorders.
- - A study on mice showed that exercise (1 hour per day) can help counteract the negative effects of PM exposure (8 hours), improving glucose and insulin tolerance and mitigating insulin resistance.
- - The findings revealed that PM exposure reduced mitrochondrial function in various tissues, but exercise helped restore mitochondrial area and expression of specific genes related to mitochondrial health, suggesting that exercise may help protect against PM-induced biological damage.
Ambient PM-induced brain injury is associated with the activation of PI3K/AKT/FoxO1 pathway.
Environ Sci Pollut Res Int
December 2021
Article Synopsis
- * Key biochemical changes included decreased levels of superoxide dismutase (SOD) and albumin, along with fluctuations in plasminogen levels, indicating possible early-stage injury followed by recovery and subsequent re-injury.
- * The study suggests that long-term PM exposure may activate the PI3K/AKT/FoxO1 signaling pathway, which could play a role in brain injuries linked to air pollution.
Different imaging characteristics between unilateral and bilateral polypoidal choroidal vasculopathy.
Photodiagnosis Photodyn Ther
June 2019
Purpose: To investigate the different imaging characteristics between unilateral and bilateral polypoidal choroidal vasculopathy (PCV) cases, based on confocal scanning laser ophthalmoscope assessment.
Methods: For this retrospective case series study, diagnostic indocyanine green angiography (ICGA) and spectral domain optical coherence tomography (SD-OCT) were performed to assess the eligible PCV eyes.
Results: Among the 53 patients at baseline, 14 showed bilateral PCV lesions, including two cases of branching vessel network (BVN) without leakage.
Article Synopsis
- Aquaporin-4 (AQP4) is a key water channel protein in the brain that helps maintain water balance in brain tissue.
- In a study, rats were infected with Streptococcus pneumoniae to model meningitis and were treated with different therapies, including dexamethasone and ceftriaxone.
- Results showed that dexamethasone reduced AQP4 expression in the brain compared to ceftriaxone alone, indicating it may have a protective effect on the central nervous system during meningitis.