Immigration documentation statuses evoke racialized faceism in mental representations.

U.S. immigration discourse has spurred interest in characterizing who illegalized immigrants are or perceived to be.

Trustworthiness judgments without the halo effect: A data-driven computational modeling approach.

Trustworthy-looking faces are also perceived as more attractive, but are there other meaningful cues that contribute to perceived trustworthiness? Using data-driven models, we identify these cues after removing attractiveness cues. In Experiment 1, we show that both judgments of trustworthiness and attractiveness of faces manipulated by a model of perceived trustworthiness change in the same direction. To control for the effect of attractiveness, we build two new models of perceived trustworthiness: a subtraction model, which forces the perceived attractiveness and trustworthiness to be negatively correlated (Experiment 2), and an orthogonal model, which reduces their correlation (Experiment 3).

Preparation of inhalable N-acetylcysteine-loaded magnetite chitosan microparticles for nitrate adsorption in particulate matter.

Airborne particulate matter has been designated as a class 1 carcinogen by the World Health Organization. Nitrate is a toxic substance that accounts for a large proportion of particulate matter, and nitrate toxicity has long been reported. In this study, we aimed to optimize the adsorption and removal of particulate matter containing nitrate for effective elimination by the lungs.

Personality Across World Regions Predicts Variability in the Structure of Face Impressions.

Research on face impressions has often focused on a fixed, universal architecture, treating regional variability as noise. Here, we demonstrated a crucial yet neglected role of cultural learning processes in forming face impressions. In Study 1, we found that variability in the structure of adult perceivers' face impressions across 42 world regions ( = 287,178) could be explained by variability in the actual personality structure of people living in those regions.

Person knowledge shapes face identity perception.

Recognition of others' identity through facial features is essential in life. Using both correlational and experimental approaches, we examined how person knowledge biases the perception of others' facial identity. When a participant believed any two individuals were more similar in personality, their faces were perceived to be correspondingly more similar (assessed via mousetracking, Study 1).

Physicochemical characterization of dapagliflozin and its solid-state behavior in stress stability test.

As an active pharmaceutical ingredient, dapagliflozin propanediol monohydrate (D-PD) has been used in the solvated form consisting of dapagliflozin compounded with (S)-propylene glycol and monohydrate at a 1:1:1 ratio. However, dapagliflozin propanediol loses the solvent's reduced lattice structure at slightly higher temperatures. Due to its sensitive solid-state stability, the temperature and humidity are strictly controlled during the production and storage of dapagliflozin.

The eye wants what the heart wants: Female face preferences are related to partner personality preferences.

Women prefer male faces with feminine shape and masculine reflectance. Here, we investigated the conceptual correlates of this preference, showing that it might reflect women's preferences for feminine (vs. masculine) personality in a partner.

Learning the affective value of people: More than affect-based mechanisms.

People's ability to learn about the affective value of others is impressive. However, it is unclear whether this learning solely reflects general affect-based processes or a mixture of affect-based and person-attribution processes. Consistent with the former possibility, people's ability to learn the affective value of people and places have been shown to be comparable (Falvello, Vinson, Ferrari, & Todorov, 2015).

Economic status cues from clothes affect perceived competence from faces.

Impressions of competence from faces predict important real-world outcomes, including electoral success and chief executive officer selection. Presumed competence is associated with social status. Here we show that subtle economic status cues in clothes affect perceived competence from faces.

Contributions of shape and reflectance information to social judgments from faces.

Face perception is based on both shape and reflectance information. However, we know little about the relative contribution of these kinds of information to social judgments of faces. In Experiment 1, we generated faces using validated computational models of attractiveness, competence, dominance, extroversion, and trustworthiness.

Preparation and evaluation of tacrolimus-loaded thermosensitive solid lipid nanoparticles for improved dermal distribution.

Tacrolimus (TCR), also known as FK-506, is a biopharmaceutics classification system (BCS) class II drug that is insoluble in water because of its high log P values. After dermal application, TCR remains in the stratum corneum and passes through the skin layers with difficulty. The objectives of this study were to develop and evaluate solid lipid nanoparticles (SLNs) with thermosensitive properties to improve penetration and retention.

Gender biases in impressions from faces: Empirical studies and computational models.

Trustworthiness and dominance impressions summarize trait judgments from faces. Judgments on these key traits are negatively correlated to each other in impressions of female faces, implying less differentiated impressions of female faces. Here we test whether this is true across many trait judgments and whether less differentiated impressions of female faces originate in different facial information used for male and female impressions or different evaluation of the same information.

Preparation, Characterization, and Stability Evaluation of Taste-Masking Lacosamide Microparticles.

Lacosamide (LCM) is a third-generation antiepileptic drug. Selective action of the drug on voltage-gated sodium channels reduces side effects. Oral administration of LCM shows good pharmacokinetic profile.

Revealing Hidden Gender Biases in Competence Impressions of Faces.

Competence impressions from faces affect important decisions, such as hiring and voting. Here, using data-driven computational models, we identified the components of the competence stereotype. Faces manipulated by a competence model varied in attractiveness (Experiment 1a).

Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection.

Background: Norquetiapine (-desalkyl quetiapine, NQ) is an active metabolite of quetiapine with stable pharmacokinetic and pharmacological properties. However, its short half-life is a drawback for clinical applications, and long-acting formulations are required.

Purpose: The objectives of this study were to prepare improved entrapment efficiency NQ freebase microspheres by the solvent evaporation method with poly(d,l-lactic-co-glycolic acid) (PLGA) as a release modulator and to evaluate their physicochemical and in vitro/in vivo release properties.

Preparation and in vivo evaluation of lecithin-based microparticles for topical delivery of minoxidil.

Minoxidil is widely used for treatment of androgenic alopecia. Commercial products containing minoxidil are usually in solution form. Repeated applications of minoxidil solution can lead to adverse effects such as skin irritation and horniness.

Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen.

The film forming gel, adhered to skin surfaces upon application and formed a film, has an advantage onto skin to provide protection and continuous drug release to the application site. This study aimed to prepare a chitosan-based film forming gel containing ketoprofen (CbFG) and to evaluate the CbFG and film from CbFG (CbFG-film). CbFG were prepared with chitosan, lactic acid and various skin permeation enhancers.