Efficacy and Safety of Kuoxin Formula in the Treatment of Dilated Cardiomyopathy-Related Heart Failure: Study Protocol of a Randomized, Double-Blind, Placebo-Controlled, Multi-Center Clinical Trial.

Background: Dilated cardiomyopathy (DCM) is a severe heterogeneous cardiomyopathy characterized by cardiac enlargement and declining heart function, often leading to refractory heart failure and life-threatening outcomes, particularly prevalent in China. The challenge lies in the scarcity of targeted therapies with substantial efficacy for DCM. Additionally, traditional anti-heart failure drugs are constrained due to hypotension propensity or limited symptom improvement.

Surface Vertical Multi-Emission Laser with Distributed Bragg Reflector Feedback from CsPbI Quantum Dots.

Quantum dots (QDs) laser has become an important way to solve micro-application problems in many fields. However, single wavelength distributed Bragg reflector (DBR) has many limitations in practical applications, such as signal transmission. How to realize multiwavelength DBR lasing output simply is a challenge.

CdTe quantum dot-based self-supporting films with enhanced stability for flexible light-emitting devices.

The enhancement of photoluminescence (PL) stability of colloidal quantum dots (CQDs) is of great significance in light-emitting devices. In this work, the PL stability of CdTe CQDs under time storage, strong light irradiation, acid and alkali corrosion and low temperature freezing is analyzed, and the PL quenching mechanism in a harsh environment is analyzed. Furthermore, the PL stability is extremely improved by core-shell coating, film deposition and polymer encapsulation.

Ultrasimple and Ultrafast Method of Optical Modulation by Perovskite Quantum Dot Attachment to a Graphene Surface.

Optical modulation is the process of modifying the structure and elemental composition of materials so that the main optical parameters, including amplitude, frequency, and phase, are changed. Currently, much research attention has been directed toward ultrafast dynamics, but the process of modulation is often complex. To simplify the optical modulation process and improve the optical properties of perovskites for semiconductor quantum dot (QD) lasers, the process and physical mechanism underlying graphene QD ultrafast modulation of the optical properties of perovskite CsPbBr QDs were investigated.

Luteolin Prevents Cardiac Dysfunction and Improves the Chemotherapeutic Efficacy of Doxorubicin in Breast Cancer.

Doxorubicin (Dox) is one of the most effective chemotherapy agents used in the treatment of solid tumors and hematological malignancies. However, it causes dose-related cardiotoxicity that may lead to heart failure in patients. Luteolin (Lut) is a common flavonoid that exists in many types of plants.

Zhoushi Qiling decoction induces apoptosis of human prostate cancer cells via miR-143/Bcl-2 axis.

A number of traditional Chinese medicines (TCMs) are widely used in prostate cancer treatment in China. The aim of this study was to test the efficacy of a TCM, Zhoushi Qiling Decoction (ZQD), in combination with androgen deprivation therapy (ADT) and explore its underlying mechanism. A total of 151 patients were recruited to receive ADT treatment or ADT+ZQD treatment.

Qi Ling Inhibits Progression of Androgen-Independent Prostate Cancer via Negative Regulation of TRIM66/HP1γ/AR Axis.

Aim: This study aimed to understand the molecular mechanism underlying the therapeutic effect of Qi Ling (QL) against androgen-independent prostate cancer.

Methods: The relative expression of TRIM66 in prostate tumor was interrogated by microarray. Real-time polymerase chain reaction and Western blotting were performed to determine the transcript abundances and protein expressions of TRIM66, HP1γ, AR, c-Myc, and GAPDH.

Micro-Structure Changes Caused by Thermal Evolution in Chalcogenide GeAsSe Thin Films by In Situ Measurements.

To understand the effects of thermal annealing on the structure of GeAsSe thin films, the thermal evolution of these films was measured by the in situ X-ray diffraction (XRD) at different temperature (773 K or 1073 K) in a vacuum (10 Pa) environment. The entire process of crystallization can be observed by using in situ XRD, which is from the appearance of a crystal structure to melting liquid-state and ultimately to the disappearance of the amorphous structure. In the crystallized process, the corresponding state-transition temperatures T (the onset crystallization temperature), T (the transition temperature from glassy-state to liquid-state), T (peak crystallization temperature) are linear with MCN (Mean Coordination Number).

Nanolasers Incorporating CoGaZnSe Nanoparticle Arrays with Wavelength Tunability at Room Temperature.

Semiconductor nanolaser has important research value and wide applications in many fields. However, it is still a challenge to obtain a nanolaser with tunability and high intensity at the nanoscale. Here, we report on lasers with two modes of emission wavelengths operating in near-infrared of nanohole filled with CoGaZnSe nanoparticle arrays at room temperature.