Mass-forming isolated ischemic necrosis of the cecum mimicking malignancy: Clinicopathologic features of 11 cases.

Isolated ischemic necrosis of the cecum (INC) is an uncommon benign condition that occurs most often in elderly patients. The clinical presentation and radiographic findings often mimic acute appendicitis or malignancy. This study aimed to investigate the clinicopathologic features of mass-forming INC.

Salvia miltiorrhiza in osteoporosis: a review of its phytochemistry, traditional clinical uses and preclinical studies (2014-2024).

Osteoporosis becomes a global public health concern due to its rising prevalence and substantial impact on life quality. Salvia miltiorrhiza Bunge (Salviae Miltiorrhizae Radix et Rhizoma, SM) has been firstly recorded in Shen Nong's Herbal Classic, and is frequently prescribed in conjunction with other herbs for the management of osteoporosis. This systematic review aims to comprehensively analyze the recent advances of SM on osteoporosis in traditional Chinese clinical uses and preclinical investigations.

Pore Characteristics and Dye Adsorption Mechanism of Functionalized UiO-66s with Various Ratios of Amino Groups.

A series of UiO-66 samples with various amino functional group ratios were prepared by modulating the proportion of terephthalic acid (HBDC) and aminoterephthalic acid (HBDC-NH) ligands, and the microstructure of the samples and dependence of methyl orange (MO) adsorption properties on the amino group content were investigated by X-ray diffraction, scanning electron microscopy, FTIR spectra, nitrogen adsorption, positron annihilation lifetime spectroscopy, and UV-vis spectra. The results showed that as the ratio of amino groups increased, the specific surface area and total porosity of the samples decreased, primarily due to decrement in the crystallinity as well as the bulky effect of amino groups in inherent pores. Interestingly, the amino-functionalized samples possessed considerable adsorption capacity of MO even in alkaline conditions due to the hydrogen bonding between the MO and -NH groups.

Chemical Auxiliary for Photocatalytic Active Colloids.

Active colloids with the ability to self-propel and collectively organize are emerging as indispensable elements in microrobotics and soft matter physics. For chemically powered colloids, their activity is often induced by gradients of chemical species in the particle's vicinity. The direct manipulation of these gradients, however, presents a considerable challenge, thereby limiting the extent to which active colloids can be controlled.

Inhibition of miR-194-5p avoids DUSP9 downregulation thus limiting sepsis-induced cardiomyopathy.

Sepsis-induced cardiomyopathy (SIC) is described as a reversible myocardial depression that occurs in patients with septic shock. Increasing evidence shows that microRNA-194-5p (miR-194-5p) participates in the regulation of oxidative stress, mitochondrial dysfunction, and apoptosis and its expression is associated with the occurrence and progression of cardiovascular disease; however, the effects of miR-194-5p in SIC are still unclear. This study explores whether miR-194-5p could modulate SIC by affecting oxidative stress, mitochondrial function, and apoptosis.

Aurora Kinase A Inhibition Potentiates Platinum and Radiation Cytotoxicity in Non-Small-Cell Lung Cancer Cells and Induces Expression of Alternative Immune Checkpoints.

Despite major advances in non-small-cell lung cancer (NSCLC) treatment, the five-year survival rates for patients with non-oncogene-driven tumors remain low, necessitating combinatory approaches to improve outcomes. Our prior high-throughput RNAi screening identified Aurora kinase A (AURKA) as a potential key player in cisplatin resistance. In this study, we investigated AURKA's role in platinum and radiation sensitivity in multiple NSCLC cell lines and xenograft mouse models, as well as its effect on immune checkpoints, including PD-L1, B7x, B7-H3, and HHLA2.

In vitro assessment of the anti-adenoviral activity of artemisinin and its derivatives.

Adenoviral infections, particularly in children, remain a significant public health issue with no approved targeted treatments. Artemisinin and its derivatives, well-known for their use in malaria treatment, have shown antiviral activities in recent studies. However, their efficacy against human adenovirus (HAdV) remains unexplored.

Correlation coefficients between normal wiggly hesitant fuzzy sets and their applications.

The multi-criteria decision-making (MCDM) field has long sought tools capable of adeptly capturing the intricacies of human decision-making amidst uncertainty. Hesitant fuzzy sets (HFS) have become a cornerstone in the MCDM field due to their ability to capture the intricacies of human decision-making under uncertainty. Nonetheless, we identified a significant gap in traditional HFS formulations, which often fail to fully harness the nuanced and implicit preferences of decision-makers (DMs).

Clinicopathologic and Molecular Characterization of Inflammatory Bowel Disease-Associated Neuroendocrine Carcinomas and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.

The pathogenesis of neuroendocrine carcinomas (NECs) and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) in the gastrointestinal tract remains poorly understood. This study aims to characterize the clinicopathologic and molecular features of NEC/MiNEN in patients with inflammatory bowel disease (IBD). Eighteen surgically resected IBD-associated intestinal carcinomas with a minimum of 30% neuroendocrine component were collected from 6 academic centers and compared with a control group of 12 IBD-associated carcinomas lacking neuroendocrine differentiation.

Highly sulfonated poly ether ether ketone chelated with Cu as a proton exchange membrane at sub-zero temperatures.

Improving the proton conductivity (σ) of proton exchange membranes at low temperatures is very important for expanding their application areas. Here, sulfonated poly ether ether ketone (SPEEK) membranes were prepared with different sulfonation degrees, and its maximum ion exchange capacity is 3.15 mmol/g for 10 h at 60 °C.

Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in Ovariectomized Rats and Bone Marrow Mesenchymal Stem Cells.

Recent interest in preventing the development of osteoporosis has focused on the regulation of redox homeostasis. However, the action of lycopene (LYC), a strong natural antioxidant compound, on osteoporotic bone loss remains largely unknown. Here, we show that oral administration of LYC to OVX rats for 12 weeks reduced body weight gain, improved lipid metabolism, and preserved bone quality.

Effectiveness and Safety of a Novel Intravascular Lithotripsy System for Severe Coronary Calcification: The CALCI-CRACK Trial.

Background: Intravascular lithotripsy is effective and safe for managing coronary calcification; however, available devices are limited, and complex lesions have been excluded in previous studies. This study aimed to investigate the effectiveness and safety of a novel intravascular lithotripsy system for severe calcification in a population with complex lesions.

Methods: CALCI-CRACK (treatment of severe calcified coronary lesions with a novel intracoronary shock wave lithotripsy system) (ChiCTR2100052058) was a prospective, single-arm, multicentre study.

PMMNet: A Dual Branch Fusion Network of Point Cloud and Multi-View for Intracranial Aneurysm Classification and Segmentation.

Intracranial aneurysm (IA) is a vascular disease of the brain arteries caused by pathological vascular dilation, which can result in subarachnoid hemorrhage if ruptured. Automatically classification and segmentation of intracranial aneurysms are essential for their diagnosis and treatment. However, the majority of current research is focused on two-dimensional images, ignoring the 3D spatial information that is also critical.

Analysis of the Risk Factors for Plastic Bronchitis in Children with Severe Adenovirus Pneumonia: A Retrospective Study.

Purpose: Plastic bronchitis (PB), a rare complication of respiratory infection characterized by the formation of casts in the tracheobronchial tree, can lead to airway obstruction and severe condition. Adenovirus is one of the common pathogens of PB caused by infection. This study aimed to evaluate the clinical features and risk factors for PB in children with severe adenovirus pneumonia.

Gut microbiota and its metabolic products in acute respiratory distress syndrome.

The prevalence rate of acute respiratory distress syndrome (ARDS) is estimated at approximately 10% in critically ill patients worldwide, with the mortality rate ranging from 17% to 39%. Currently, ARDS mortality is usually higher in patients with COVID-19, giving another challenge for ARDS treatment. However, the treatment efficacy for ARDS is far from satisfactory.

Enhancing aerobic composting performance of high-salt oily food waste with Bacillus safensis YM1.

To alleviate the inhibitory effects of salt and oil on food waste compost, the compost was inoculated with salt-tolerant and oil-degrading Bacillus safensis YM1. The YM1 inoculation could effectively improve compost maturation index. Compared with uninoculated group, the oil content and Cl concentration in the 0.

Assessing the Role of Gaseous Chlorine Dioxide in Modulating the Postharvest Ripening of Keitt Mangoes through the Induction of Ethylene Biosynthesis.

Consumer acceptance of Keitt mangoes ( L.) is significantly affected by their slow postharvest ripening. This work used gaseous chlorine dioxide (ClO(g)) to prepare the ready-to-eat Keitt mango and explored the potential mechanisms for the mango ripening.

Incidental findings during donor liver assessment: Single center experience.

Intraoperative consultation of donor liver is an important part of transplant evaluation and determination of liver eligibility. In this study, we describe incidental pathologic findings discovered during the pretransplant evaluation of liver donors in our Institution from 1/2010 to 12/2022. During this 13-year period 369 intraoperative consultations from 262 liver donors were performed.

Uniform Homeostatic Stress Through Individualized Interval Training Facilitates Homogeneous Adaptations Across Rowers With Different Profiles.

Purpose: This study compared the effects of individualizing supramaximal interval rowing interventions using anaerobic power reserve (APR [high-intensity interval training (HIIT) prescribed according to individual APR (HIITAPR)]) and power associated with maximal oxygen uptake (WV˙O2max [HIIT prescribed based on the individual WV˙O2max (HIITW)]) on the homogeneity of physiological and performance adaptations.

Methods: Twenty-four well-trained rowers (age 24.8 [4.

Role of the cAMP-PKA-NF-κB pathway in Mucin1 over-expression in A549 cells during Respiratory syncytial virus infection.

Respiratory syncytial virus (RSV) is the most common pathogen associated with acute lower respiratory tract infections in infants and young children worldwide. RSV commonly presents as bronchiolitis in young children; however, it can sometimes progress to pneumonia, respiratory failure, apnoea and even death. Although mucin1 (MUC1), a type of transmembrane glycoprotein present on airway epithelial surfaces, plays a crucial anti-inflammatory role in airway infections; however, its roles in RSV-associated acute lower respiratory tract infections have rarely been explored.

Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice.

Ethnopharmacological Relevance: Fuling-Zexie (FZ) formula, a traditional Chinese herbal prescription composed of Poria cocos (Schwan.) Wolf. (Poria), Pueraria lobate (Willd.