Renal injury in NSAIDs: a real-world analysis based on the FAERS database.

Objective: This study aims to evaluate the reporting risk of renal injury associated with non-steroidal anti-inflammatory drugs (NSAIDs), with a particular focus on the reporting risk levels and onset times of different NSAIDs.

Methods: A pharmacovigilance study was conducted using data from the FAERS database from January 2004 to December 2023. Reports of renal injury were identified, and signal detection was performed using reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN) methods.

Ocu-miR-10a-5p promotes the chondrogenic differentiation of rabbit BMSCs by targeting BTRC-mediated Wnt/β-catenin signaling pathway.

MicroRNAs (miRNAs) play an important role in articular cartilage damage in osteoarthritis (OA). However, the biological role of miRNAs in the chondrogenic differentiation of bone marrow mesenchymal stem cell (BMSC) remains largely unclear. Rabbit bone marrow mesenchymal stem cells (rBMSCs) were isolated, cultured, and identified.

Establishing a unified paradigm of microwave absorption inspired by the merging of traditional microwave absorbing materials and metamaterials.

The merging of traditional microwave absorbing materials with metamaterials holds significant potential for enhancing microwave absorber performance. To unlock this potential, a unified paradigm is urgently required. We have successfully established such a paradigm, focusing on regulating effective electromagnetic parameters and interfacial forms across microscopic, mesoscopic, and macroscopic scales.

Icariin promotes the repair of bone marrow mesenchymal stem cells in rabbit knee cartilage defects via the BMP/Smad pathway.

Background: Icariin (ICA) has been widely used in the treatment of osteoporosis. However, the potential mechanism of its critical role in repairing knee cartilage damage still needs to be further clarified.

Methods: First, rabbit bone marrow mesenchymal stem cells (BMSCs) were isolated, cultured, and identified.

Icariin protects rabbit BMSCs against OGD-induced apoptosis by inhibiting ERs-mediated autophagy via MAPK signaling pathway.

Stem cell therapy is widely employed in treating osteoarthritis (OA), and bone marrow-derived mesenchymal stem cells (BMSCs) has gradually become the most attractive new method for treating OA due to the benefit for cartilage tissue repair. However, the apoptosis in the neural stem cell transplantation severely decreases repairing efficacy. Icariin has been reported to exert multiple effects on BMSCs, including its proliferation, osteogenic, and chondrogenic differentiation.

Strong electric wave response derived from the hybrid of lotus roots-like composites with tunable permittivity.

Lotus roots-like NiO/NiCoO hybrids derived from Metal-organic frameworks (MOFs) are fabricated for the first time by using flake NiCo-MOF precursors as reactant templates. It was found that a thin sample consisting of 60 wt % NiO/NiCoO hybrids in the wax matrix exhibited an effective microwave absorption bandwidth of 4.2 GHz at the thickness of 1.

Distinct enhancement of sub-bandgap photoresponse through intermediate band in high dose implanted ZnTe:O alloys.

The demand for high efficiency intermediate band (IB) solar cells is driving efforts in producing high quality IB photovoltaic materials. Here, we demonstrate ZnTe:O highly mismatched alloys synthesized by high dose ion implantation and pulsed laser melting exhibiting optically active IB states and efficient sub-gap photoresponse, as well as investigate the effect of pulsed laser melting on the structural and optical recovery in detail. The structural evolution and vibrational dynamics indicates a significant structural recovery of ZnTe:O alloys by liquid phase epitaxy during pulsed laser melting process, but laser irradiation also aggravates the segregation of Te in ZnTe:O alloys.

CoxFey@C Composites with Tunable Atomic Ratios for Excellent Electromagnetic Absorption Properties.

The shell on the nano-magnetic absorber can prevent oxidation, which is very important for its practical utilization. Generally, the nonmagnetic shell will decrease the integral magnetic loss and thus weaken the electromagnetic absorption. However, maintaining the original absorption properties of the magnetic core is a major challenge.

Coin-like α-Fe2O3@CoFe2O4 core-shell composites with excellent electromagnetic absorption performance.

In this paper, we designed a novel core-shell composite for microwave absorption application in which the α-Fe2O3 and the porous CoFe2O4 nanospheres served as the core and shell, respectively. Interestingly, during the solvothermal process, the solvent ratio (V) of PEG-200 to distilled water played a key role in the morphology of α-Fe2O3 for which irregular flake, coin-like, and thinner coin-like forms of α-Fe2O3 can be produced with the ratios of 1:7, 1:3, and 1:1, respectively. The porous 70 nm diameter CoFe2O4 nanospheres were generated as the shell of α-Fe2O3.

RapidMic: Rapid Computation of the Maximal Information Coefficient.

To discover relationships and associations rapidly in large-scale datasets, we propose a cross-platform tool for the rapid computation of the maximal information coefficient based on parallel computing methods. Through parallel processing, the provided tool can effectively analyze large-scale biological datasets with a markedly reduced computing time. The experimental results show that the proposed tool is notably fast, and is able to perform an all-pairs analysis of a large biological dataset using a normal computer.

A Poisson-based adaptive affinity propagation clustering for SAGE data.

Serial analysis of gene expression (SAGE) is a powerful tool to obtain gene expression profiles. Clustering analysis is a valuable technique for analyzing SAGE data. In this paper, we propose an adaptive clustering method for SAGE data analysis, namely, PoissonAPS.

Modified fractal model and rheological properties of colloidal networks.

The scaling relationship between the storage modulus (G(')) and the volume fraction of solids (Phi) in fat crystal networks has been explained by the fractal model developed by our group. However, many experimental results and simulation studies suggest that the stress distribution within a colloidal network is dramatically heterogeneous, which means that a small part of the network carries most of the stress, while the other part of the network does not contribute much to the elastic properties of the system. This concept was introduced into a modified fractal model.

Quantitative study on the microstructure of colloidal fat crystal networks and fractal dimensions.

This paper highlights the most recent progress in the quantitative study on the microstructure and the rheological properties of colloidal fat crystal networks. Several physical models describing the structural hierarchy of the colloidal fat crystal networks are reviewed here, with particular emphasis on fractal model, which can be used to explain the scaling behavior of fat crystal networks. The concept of the fractal dimension has been extensively used in the quantitative study of the microstructure of fat crystal networks and other colloidal networks; however, the relationship between the fractal dimension value and microstructural characteristics remains somewhat nebulous.