Publications by authors named "DongMei Wang"

Recent studies demonstrate that lipid peroxidation-induced ferroptosis participates in 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-evoked neurotoxicity and cognitive dysfunction. Melatonin has been indicated to confer neuroprotection against brain diseases via its potent anti-ferroptotic effects. Therefore, this study aims to explore whether melatonin can mitigate BDE-47-elicited cognitive impairment via suppressing ferroptosis, and further delineate the underlying mechanisms.

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Introduction: This review delves into the intricate relationship between NLR inflammasomes, particularly the NLRP3 inflammasome, and the immune-mediated neurodegenerative disease, multiple sclerosis (MS). While the precise etiology of MS remains elusive, compelling research underscores the pivotal role of the immune response in disease progression. Notably, recent investigations highlight the significant involvement of NLRP3 inflammasomes in various autoimmune diseases, prompting an in-depth exploration of their impact on MS.

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Drought stress damages the growth and development of maize, which results in the maize yield reduction. A strong root system improves the drought tolerance in maize. A previous genome-wide association study for the maize seminal root length under drought stress conditions identified a significant SNP, which was located in the ZmEULD1b gene.

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Objectives: It is common for patients with schizophrenia to exhibit symptoms of autism. Both autism spectrum disorders and schizophrenia share similar patterns of empathy deficits. This study purposed to explore the association between autistic features and empathy in Chinese patients with chronic schizophrenia.

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Although ultrasound therapy is efficacious and safe in clinical oncology, its capacity to elicit an anti-tumor immune response is constrained by ultrasound-induced apoptosis. Pyroptosis, which releases immunogenic damage-associated molecular patterns (DAMPs), can significantly enhance immune activation. It necessitates robust Gasdermin E (GSDME) expression in cancer cells for caspase-3-mediated pyroptosis.

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Overcoming the poor physicochemical properties of pure alginate gel and the inherent shortcomings of pure metal-organic framework (MOF), alginate/MOF composite gel has captured the interest of many researchers as a tunable platform with high stability, controllable pore structure, and enhanced biological activity. Interestingly, different from the traditional organic or inorganic nanofillers physically trapped or chemically linked within neTtworks, MOFs crystals can not only be dispersed by crosslinking polymerization, but also support self-assembly in-situ under the help of chelating cations with alginate. The latter is influenced by multiple factors and may involve some complex mechanisms of action, which is also a topic discussed deeply in this article while summarizing different preparation routes.

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Muscular atrophy is among the systematic decline in organ functions in aging, while defective thermogenic fat functionality precedes these anomalies. The potential crosstalk between adipose tissue and muscle during aging is poorly understood. In this study, it is showed that UCP1 knockout (KO) mice characterized deteriorated brown adipose tissue (BAT) function in aging, yet their glucose homeostasis is sustained and energy expenditure is increased, possibly compensated by improved inguinal adipose tissue (iWAT) and muscle functionality compared to age-matched WT mice.

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Introduction: Chronic Ankle Instability (CAI) is a chronic syndrome resulting from repeated ankle sprains that lead to persistent dysfunction.the purpose of this study is to determine whether visual disruption could influence static and dynamic postural control in people with and without chronic ankle instability (CAI), with the objective of gaining a comprehensive understanding of the interactions between visual inputs and postural control.

Methods: Thirty people with CAI (21 males and 9 females, age = 22.

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Background: Cognitive impairment is a common clinical symptom of patients with major depressive disorder (MDD). Transcranial magnetic stimulation-evoked potentials (TEPs) detect cortical excitability and connectivity and provide potential biomarkers for MDD patients and their cognitive impairment. This study aimed to investigate the interrelationships between clinical symptoms, cognitive function, and electrophysiological marker TEPs in patients with MDD.

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Background And Objectives: Both β-arrestin2 and nicotinic acetylcholine receptor (nAChR) have been implicated in cognitive processes, particularly in relation to psychiatric disorders, including addiction. Previous studies have suggested that nAChR may be regulated by β-arrestin2. However, no study has investigated the interaction of β-arrestin2 and nAChR on cognition.

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Importance: Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are both recognized as effective treatments for depression when applied individually. However, it is unknown whether rTMS combined with tDCS has better efficacy in the treatment of major depressive disorder (MDD).

Objective: To investigate the clinical effectiveness and safety of rTMS, tDCS, tDCS + rTMS, and sham tDCS + sham rTMS after 2 weeks of treatment in patients with MDD.

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The human gut microbiota is diverse and abundant and plays important roles in regulating health by participating in metabolism and controlling physiological activities. The gut microbiota and its metabolites have been shown to affect the functioning of the gut and central nervous system through the microbiota-gut-brain axis. It is well established that microbiota play significant roles in the pathogenesis and progression of Parkinson's disease (PD).

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Introduction: Multifunctional nanomaterials are emerging as promising tools for treating both cancer and bacterial infections. However, integrating dual therapeutic capabilities into a single system remains challenging. This study presents multifunctional nanoparticles (ECI-NPs) based on Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), and Indocyanine Green (ICG) for combined cancer and bacterial treatment.

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Objectives: Neuroimaging studies have reported extensive resting-state functional connectivity (rsFC) abnormalities in the default mode network (DMN) in patients with obsessive-compulsive disorder (OCD), but findings are inconsistent. DMN can be divided into three subsystems: core, dorsal medial prefrontal cortex (dMPFC), and medial temporal lobe (MTL). This study aimed to explore abnormalities in rsFC strength within and between DMN subsystems in OCD patients, and their relationship with clinical symptoms.

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Background: Interleukin-1β (IL-1β) plays a crucial role in cartilage degeneration by inducing inflammatory cascades in chondrocytes, impairing their normal biological functions. Long non-coding RNA NKILA (lncRNA NKILA) has been implicated in osteoarthritis (OA), but its specific molecular mechanisms remain unclear. This study aims to elucidate the function and molecular regulatory mechanism of lncRNA NKILA in articular chondrocytes under IL-1β stimulation.

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Article Synopsis
  • A study was conducted to compare the quality of recovery in elderly patients (65+) after surgery using two anesthetic agents: ciprofol and propofol, focusing on QoR-15 scores as the measure of recovery.
  • The trial was a prospective, double-blind, randomized non-inferiority design involving 144 participants, who were divided into two groups, one receiving ciprofol and the other propofol during their procedures.
  • Results showed that the recovery scores for the ciprofol group were not significantly worse than those for the propofol group on the first postoperative day and remained comparable on subsequent days, suggesting ciprofol is a suitable alternative to propofol for elderly patients.
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  • Ridge-furrow tillage is a key method in dry farming that can enhance yields, but the effects of mulching and biochar on soil properties and crop yields in this system were previously unclear.
  • A three-year study showed that adding mulch and biochar significantly influenced soil characteristics, enzyme activity, and microbial communities, altering nutrient cycling and bacterial diversity under ridge-furrow conditions.
  • Results indicated that while mulching improved crop yields, it also reduced certain enzyme activities; biochar addition helped counteract some negative effects of mulching and further boosted crop production, especially for alfalfa.
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  • The study compared the safety and effectiveness of Del Nido cardioplegia (DNC) with conventional blood cardioplegia (CBC) in patients undergoing combined aortic surgery from September 2017 to July 2023.
  • 223 patients were evaluated, showing no significant demographic differences between the DNC and CBC groups, and no in-hospital mortality was recorded.
  • DNC required less cardioplegia volume and infusion times, resulted in higher rates of spontaneous rhythm return, and led to shorter durations of mechanical ventilation and hospital stays compared to CBC.
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Background: Infertility is a significant national public health concern, and the World Health Organization (WHO) predicts that it will rank as the third most prevalent disease following tumors, cardiovascular and cerebrovascular diseases. The impact of dysfunctional lipoproteins on female infertility remains relatively understudied; therefore, the research focuses on exploring the relationship between serum high-density lipoprotein (HDL) concentration and infertility.

Methods: This is a retrospective cross-sectional study where we employed multivariate logistic regression analysis to examine the association between serum HDL concentrations and female infertility.

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  • * Exposure to BPS affects the insulin/IGF-like signaling (IIS) pathway, leading to reduced expression of the daf-16 transcription factor and its related anti-oxidative genes.
  • * Quercetin shows promise in mitigating the harmful effects of BPS by reversing the alterations in the IIS/daf-16 pathway and improving oxidative stress markers, suggesting a potential treatment for BPS-induced aging.
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In drug delivery systems, a stimuli-responsive linker that attaches a targeting carrier and a cytotoxic payload can be dissociated to release the payload on the target over the action of a stimuli, thereby it would harden the selectivity, specificity and potency of the cytotoxic agent against targeted tissues whilst sparing the drug-induced toxicity on normal cells. Oligonucleotide duplexes can unwind and be separated into single-stranded random coils under a defined temperature, and this property makes the oligonucleotide an appealing thermo-responsive linker. In this work, we studied the melting temperatures of different DNA linkers with various lengths and mismatches inserted in the double helix with either different numbers or positions.

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  • China faces a significant challenge with postherpetic neuralgia, necessitating effective new treatment options that minimize neurotoxic effects compared to current calcium channel ligands.
  • The study aimed to evaluate the efficacy and safety of crisugabalin, a new oral medication, involving a randomized clinical trial across 48 care centers in China, which included a 12-week treatment phase and a subsequent 14-week extension phase.
  • Results showed improvement in pain relief for patients taking crisugabalin, particularly at the 40 mg and 80 mg doses, highlighting its potential as a more effective treatment for managing postherpetic neuralgia compared to a placebo.
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  • Residual tumours that don't completely disappear after radiotherapy can develop resistance, making treatment difficult and increasing the chance of cancer returning or spreading.
  • Researchers found that two proteins, FDX1 and LIAS, were more active in these resistant tumours, making them more sensitive to a form of cell death called cuproptosis.
  • The study proposes a new treatment approach using copper-releasing nanocapsules that, when exposed to radiation, can effectively trigger cuproptosis and improve cure rates, even in challenging cases.
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