Sex differences in clinically diagnosed psychiatric disorders over the lifespan: a nationwide register-based study in Sweden.

Background: Limited studies exist on sex differences in incidence rates of psychiatric disorders across the lifespan. This study aims to analyze sex differences in the incidence rates of clinically diagnosed psychiatric disorders over the lifespan.

Methods: We conducted a nationwide register-based cohort study, including all individuals who were born in Sweden and lived in Sweden between 2003 and 2019, including 4,818,071 females and 4,837,829 males.

Piperidine and bis-piperidine alkaloids from the peels of Areca catechu and their monoamine oxidases inhibitory activity.

Eleven undescribed piperidine alkaloids, arecachines A‒J (1-11), were isolated from the peels of Areca catechu. Compounds 8-11 are featured as bis-piperidine alkaloids. Their structures were elucidated by analysis of UV, IR, HRESIMS, 1D and 2D NMR spectra.

Prevalence of Life Stressors and Posttraumatic Stress Disorder Among Women in Iceland.

Importance: Comprehensive data on the prevalence of various life stressors and their role in posttraumatic stress disorder (PTSD) among women are lacking.

Objective: To determine the prevalence of a broad range of life stressors and their association with PTSD in a large nationally representative cohort of women.

Design, Setting, And Participants: This cross-sectional analysis used data from the population-based Stress-And-Gene-Analysis, which invited women in Iceland to complete an online survey from March 1, 2018, to July 1, 2019.

Depression in childhood to early adulthood and respiratory health in early adulthood.

Background: Both depression and respiratory disease are common today in young populations. However, little is known about the relationship between them.

Aims: This study aims to explore the association between depression in childhood to early adulthood and respiratory health outcomes in early adulthood, and the potential underlying mechanisms.

The role of mental illness and neurodevelopmental conditions in human papillomavirus vaccination uptake within the Swedish school-based vaccination programme: a population-based cohort study.

Background: Despite documented mental illness-related disparities in cervical cancer screening and incidence, insufficient data exist on differences in cervical cancer prevention strategies, such as human papillomavirus (HPV) vaccination. We aimed to investigate the association of mental illness and neurodevelopmental conditions among girls and their parents with uptake of HPV vaccination in Sweden.

Methods: This population-based cohort study was based on the Swedish school-based HPV vaccination programme, which offers the first vaccine dose to girls aged 10-13 years, with a second dose offered within 12 months.

Association between severe premenstrual disorders and change of romantic relationship: A prospective cohort of 15,606 women in Sweden.

Background: Premenstrual disorders (PMDs) affect women's quality of life, yet the impact on romantic relationships remains unclear. This study aimed to examine the association between severe PMDs and relationship disruption and initiation.

Methods: We conducted a prospective cohort study of 15,606 women during 2009-2021 in Sweden.

Psychiatric morbidity across the life course and provoked vulvodynia: is it dependent upon the presence of non-stress-related immune dysfunction?

Background: Vulvodynia impacts up to 8% of women by age 40, and these women may have a more compromised immune system than women with no vulvar pain history.

Aim: Given that psychiatric morbidity is associated with vulvodynia and is known to activate immune inflammatory pathways in the brain and systemically, we sought to determine whether the association between psychiatric morbidity and vulvar pain was independent of or dependent upon the presence of immune-related conditions.

Methods: Women born in Sweden between 1973 and 1996 with localized provoked vulvodynia (N76.

Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study.

Background And Aims: Increasing evidence suggests that some reproductive factors/hazards are associated with a future risk of cardiovascular disease (CVD) in women. While major (non-perinatal) depression has consistently been associated with CVD, the long-term risk of CVD after perinatal depression (PND) is largely unknown.

Methods: A nationwide population-based matched cohort study involving 55 539 women diagnosed with PND during 2001-14 in Sweden and 545 567 unaffected women individually matched on age and year of conception/delivery was conducted.

Shared genetic effect of kidney function on bipolar and major depressive disorders: a large-scale genome-wide cross-trait analysis.

Background: Epidemiological studies have revealed a significant association between impaired kidney function and certain mental disorders, particularly bipolar disorder (BIP) and major depressive disorder (MDD). However, the evidence regarding shared genetics and causality is limited due to residual confounding and reverse causation.

Methods: In this study, we conducted a large-scale genome-wide cross-trait association study to investigate the genetic overlap between 5 kidney function biomarkers (eGFRcrea, eGFRcys, blood urea nitrogen (BUN), serum urate, and UACR) and 2 mental disorders (MDD, BIP).

Mortality Risk Among Women With Premenstrual Disorders in Sweden.

Importance: Premenstrual disorders (PMDs) adversely affect the quality of life of millions of women worldwide, yet research on the long-term consequences of PMDs is limited, and the risk of mortality has not been explored.

Objective: To estimate the associations of PMDs with overall and cause-specific mortality.

Design, Setting, And Participants: This nationwide, population-based, matched cohort study used data from population and health registers in Sweden.

The bidirectional association between premenstrual disorders and perinatal depression: A nationwide register-based study from Sweden.

Background: Premenstrual disorders (PMDs) and perinatal depression (PND) share symptomology and the timing of symptoms of both conditions coincide with natural hormonal fluctuations, which may indicate a shared etiology. Yet, there is a notable absence of prospective data on the potential bidirectional association between these conditions, which is crucial for guiding clinical management. Using the Swedish nationwide registers with prospectively collected data, we aimed to investigate the bidirectional association between PMDs and PND.

Incidence of oncogenic HPV infection in women with and without mental illness: A population-based cohort study in Sweden.

Background: Women with mental illness experience an increased risk of cervical cancer. The excess risk is partly due to low participation in cervical screening; however, it remains unknown whether it is also attributable to an increased risk of infection with human papillomavirus (HPV). We aimed to examine whether women with mental illness had an increased infection rate of HPV compared to women without mental illness.

Adverse Childhood Experiences and Adult Mental Health Outcomes.

Importance: Exposure to adverse childhood experiences (ACEs) has consistently been associated with multiple negative mental health outcomes extending into adulthood. However, given that ACEs and psychiatric disorders cluster within families, it remains to be comprehensively assessed to what extent familial confounding contributes to associations between ACEs and clinically confirmed adult psychiatric disorders.

Objective: To investigate whether associations between ACEs and adult mental health outcomes remain after adjusting for familial (genetic and environmental) confounding.

Perinatal depression and risk of mortality: nationwide, register based study in Sweden.

Objective: To determine whether women with perinatal depression are at an increased risk of death compared with women who did not develop the disorder, and compared with full sisters.

Design: Nationwide, register based study.

Setting: Swedish national registers, 1 January 2001 to 31 December 2018.

Bidirectional association between autoimmune disease and perinatal depression: a nationwide study with sibling comparison.

Although major depression, characterized by a pro-inflammatory profile, genetically overlap with autoimmune disease (AD) and the perinatal period involve immune system adaptations and AD symptom alterations, the bidirectional link between perinatal depression (PND) and AD is largely unexplored. Hence, the objective of this study was to investigate the bidirectional association between PND and AD. Using nationwide Swedish population and health registers, we conducted a nested case-control study and a matched cohort study.

Exploring spatiotemporal pattern in the association between short-term exposure to fine particulate matter and COVID-19 incidence in the continental United States: a Leroux-conditional-autoregression-based strategy.

Background: Numerous studies have demonstrated that fine particulate matter (PM) is adversely associated with COVID-19 incidence. However, few studies have explored the spatiotemporal heterogeneity in this association, which is critical for developing cost-effective pollution-related policies for a specific location and epidemic stage, as well as, understanding the temporal change of association between PM and an emerging infectious disease like COVID-19.

Methods: The outcome was state-level daily COVID-19 cases in 49 native United States between April 1, 2020 and December 31, 2021.

Using a time-varying LCAR-based strategy to investigate the spatiotemporal pattern of association between short-term exposure to particulate matter and COVID-19 incidence: a case study in the continental USA.

Numerous studies have demonstrated that short-term exposure to particulate matter less than 10 μm (PM) is positively associated with the COVID-19 incidence. However, no study has investigated the spatiotemporal pattern in this association, which plays important roles in identifying high-susceptibility regions and stages of epidemic. In this work, taking the 49 native states in America as an example, we used an advanced strategy to investigate this issue.

Association between adverse childhood experiences and perinatal depressive symptoms: a cross-sectional analysis of 16,831 women in Iceland.

Emerging data suggest that certain adverse childhood experiences (ACEs) are associated with perinatal depression (PND). However, few studies have comprehensively assessed the cumulative number and types of ACEs and their association to PND. We conducted a cross-sectional analysis among 16,831 female participants from the Stress-And-Gene-Analysis (SAGA) cohort in Iceland, 2018.