Polyhydroxyalkanes from Sieb. et Zucc.

Four polyhydroxyalkanes were isolated from the CHCl part of , including two new ones, (2,3)-3-isopropylpent-3-ene-1,2,5-triol () and (4,2)-4,5-dihydroxy-2,3-dimethylpent-2-enoic acid (); as well as one new natural product, 3-methylbut-3-ene-1,2-diol () and one known compound, 4-methyl-3-methylenepentane-1,2-diol (). The structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D NMR, IR, HR-ESI-MS, and ECD data. The cytotoxic activity of compounds against the human cancer lines A549, H460, and HepG2 cell lines of the isolated compounds was evaluated by the CCK8 method.

Evaluating Blended Teaching Models in Medical Colleges: Preferences and Influential Factors for Teachers and Students.

Objective: This study evaluates the adoption of blended teaching models by faculty and students at Hubei University of Medicine. It aims to assess their willingness to adopt hybrid learning and identify the factors influencing their choices. The goal is to provide a theoretical foundation for reforming teaching models.

Fumarate Hydratase-Deficient Leiomyoma with Double Mutation Sites in the FH : A Rare Case Report and Literature Review.

Background: Fumarate Hydratase (FH)-deficient uterine leiomyomas are a rare type of uterine fibroid associated with somatic or germline mutations in the FH gene. Herein, we report a case of FH-deficient uterine leiomyoma with a double-site mutation of in a 41-year-old woman.

Case Presentation: The woman was found to have an intrauterine mass during a routine physical examination two years prior.

High-Responsivity Self-Powered Photoelectrochemical UV Photodetector Based on Integrated Self-Supporting SiC/ZnS Heterojunction Nanowire Arrays.

In the realm of photodetector (PD) technology, photoelectrochemical (PEC) PDs have garnered attention owing to their inherent advantages. Advances in this field depend on functional nanostructured materials, which are pivotal in improving the separation and transport of photogenerated electron-hole pairs to improve device efficiency. Herein, a highly photosensitive PEC UV PD is built using integrated self-supporting SiC/ZnS heterojunction nanowire array photoelectrodes through anodization and chemical deposition.

Association between brachial-ankle pulse wave velocity, obesity-related indices, and the 10-year incident risk score of atherosclerotic cardiovascular disease: The rural Chinese cohort study.

Background And Aims: Although existing evidence suggests that arterial stiffness and obesity impact cardiovascular health, limited studies have been conducted to explore the association between brachial-ankle pulse wave velocity (baPWV), obesity-related indices, and the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods And Results: The study participants were among those who completed the baPWV measurement at the second follow-up examination (during 2018-2020) of the Rural Chinese Cohort Study. Logistic regression models were employed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) of the 10-year incident risk score of ASCVD associated with baPWV and obesity-related indices.

Effect of fucoidan supplementation on glycolipid metabolism, systemic inflammation and gut microbiota in prediabetes: A randomized controlled trial.

Prediabetes is characterized as a transitional phase between normal blood glucose and diabetes, and the potential role of fucoidan in the progression of diabetes is still debated. The randomized, double-blind, placebo-controlled trial was designed to assess the effect of fucoidan supplementation on glycolipid metabolism, systemic inflammation and gut microbiota in individuals with prediabetes. A total of 70 Chinese participants with prediabetes were randomized to either fucoidan or placebo group, receiving daily doses of 1000 mg fucoidan or placebo capsules for 12 weeks.

Surface Oxygen Engineering Catalytic Pore Tailoring of Coal-Based Needle Coke toward Capacitive Porous Carbon.

Coal-based needle coke (CNC) is an ideal carbon precursor for capacitive materials due to its layered graphitic structure and high electrical conductivity. However, the pore-rich engineering and graphitic structural inheriting of CNC-derived carbon during the conventional activation process present challenges. Herein, a surface oxygen engineering catalytic pore tailoring strategy is developed to manipulate the porous structures of CNC-derived porous carbon.

Immune Suppression and Rapid Invasion of Nile Tilapia Gills Following an Acute Challenge by .

is one of the causative agents of columnaris disease, significantly impacting Nile tilapia aquaculture. This study examines the invasion and immune evasion mechanisms of a highly virulent strain through transcriptomic profiling of tilapia gills following acute immersion. We identified 8192 differentially expressed genes (DEGs) at 2 h, 6 h, and 12 h post-infection.

Relationship between trajectory of Chinese visceral adiposity index and risk of type 2 diabetes mellitus: Evidence from the China-PAR project.

Aims: This study aimed to identify the distinct change trajectories of the Chinese visceral adiposity index (CVAI) over time and to investigate their associations with risk of type 2 diabetes mellitus (T2DM).

Materials And Methods: This study included 52 394 participants from the prospective project, the Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR). The CVAI was calculated using measures of age, body mass index, waist circumference, triglycerides and high-density lipoprotein cholesterol.

Botany, Traditional Use, Phytochemistry, Pharmacology and Clinical Applications of Rhubarb (Rhei Radix et Rhizome): A Systematic Review.

Rhubarb, the Rhei radix et rhizoma (Da huang) is a member of the Polygonaceae family, included in the 2020 edition of the Chinese Pharmacopoeia, and is mainly distributed in Gansu, Sichuan, Qinghai, northwestern Yunnan, and eastern Tibet. Rhei radix et rhizoma is one of the most commonly used traditional Chinese medicines, processed into drinkable tablets in different concoctions for clinical use. Phytochemical studies showed that more than 170 compounds were isolated and identified from Rhei radix et rhizoma, including anthraquinones/anthrones (major constituents), stilbenes, chromones, flavonoids, tannins, and other compounds, etc.

Saponins as potential novel NLRP3 inflammasome inhibitors for inflammatory disorders.

Nucleotide-binding domain leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) is a downstream protein from the pattern recognition receptor family that forms the NLRP3 inflammasome. The NLRP3 inflammasome releases caspase-1, IL-1β, and IL-18, contributing to inflammatory responses associated with diabetes mellitus, arthritis, and ischemia-reperfusion injury. Recent studies suggest that specific saponin monomers and extracts from traditional Chinese medicines can inhibit inflammatory responses and related pathways, including the production of inflammatory factors.

Organic matter accumulation under the Middle-Upper Ordovician tectonic transition on the western margin of the North China platform.

The tectonic of the Middle and Late Ordovician in the western margin of the north China Platform is complex, and the accumulation models of organic matter of the Wulalike Formation formed during this period are still unclear. Total organic carbon (TOC) content, mineral composition, organic carbon isotope composition, as well as the major and trace elements in the shale samples were all measured in this study. The Wulalike Formation was formed during a tectonic transition from a passive continental margin to an active continental margin.

Identification of an Immune signature assisted prognosis, and immunotherapy prediction for IDH wildtype glioblastoma.

IDH-wildtype glioblastoma (GBM) is the most common and malignant primary brain tumor. The purpose of this study is to establish a prognostic gene signature for IDH-wildtype GBM. RNA sequencing data of normal brain tissue and GBM patients were obtained from TCGA, CGGA, GEO and the GTEx databases.

Air-condition process for Constructing MeAl-LDHs/rGO (Me = Co, Ni, Fe) hybrids toward efficient oxygene evolution reaction.

Transition-metal-based layered double hydroxides (LDHs) are emerging as one of the most promising candidates with superior oxygen evolution reaction (OER) activity. However, their fabrication under mild conditions remains a significant challenge. Here, we propose a low-cost, high-production-rate strategy for controlled preparation of AlOOH/reduced graphene oxide (rGO) with strong adsorption capacity for transition metal cations, and then in-situ conversion to CoAl-LDH/rGO, NiAl-LDH/rGO and FeAl-LDH/rGO under ambient conditions.

Identification of diagnostic markers pyrodeath-related genes in non-alcoholic fatty liver disease based on machine learning and experiment validation.

Non-alcoholic fatty liver disease (NAFLD) poses a global health challenge. While pyroptosis is implicated in various diseases, its specific involvement in NAFLD remains unclear. Thus, our study aims to elucidate the role and mechanisms of pyroptosis in NAFLD.

Pre-Corrosion of Zinc Metal Anodes for Enhanced Stability and Kinetics.

Non-uniform zinc plating/stripping in aqueous zinc-ion batteries (ZIBs) often leads to dendrites formation and low Coulombic efficiency (CE), limiting their large-scale application. In this study, a pre-corroded Zn (PC-Zn) anode with 3D ridge-like structure is constructed by a facile solution etching in sodium hypophosphite (NaHPO) solution. The surface preparation process can significantly remove impurities from the passivation layer of bare Zn anode, thus exposing a great quantity of active sites for easy plating/stripping.