Publications by authors named "Dong-zi Lin"
Noninvasive and simple indicators for diagnosing latent tuberculosis (TB) infection (LTBI) and tracking progression from latent infection to active TB infection are still desperately needed. The aim of this study was to screen and identify possible biomarkers for diagnosing LTBI and monitoring the progression from latent infection to active TB infection, as well as to investigate the underlying processes and functions. To assess changes in metabolite composition associated with active tuberculosis infection in humans, whole blood supernatants were collected from patients with LTBI, drug-susceptible TB patients, drug-resistant TB patients, and healthy controls.
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- The study investigated the role of HMGB1 in patients with active pulmonary tuberculosis (APTB) by measuring its levels in plasma and sputum, along with various inflammatory cytokines and immune cells.
- Results showed that APTB patients had significantly higher levels of HMGB1 and cytokines (IL-6, IL-10, and TNF-α) compared to healthy volunteers, indicating an association with inflammation.
- The findings suggest that HMGB1 could serve as a potential biomarker for diagnosing and predicting the prognosis of APTB, reflecting the inflammatory state of monocytes in these patients.
Despite past extensive studies, the role of B and T lymphocyte attenuator (BTLA) in αβ T cells in patients with active pulmonary tuberculosis (ATB) remains poorly understood. Here we demonstrate that BTLA expression on αβ T cells is decreased in patients with M. tuberculosis (Mtb) infection.
View Article and Find Full Text PDF[Association of filaggrin gene polymorphism with atopic dermatitis in southern Chinese Han population].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2011
Objective: To investigate the association of filaggrin gene (FLG) polymorphism with atopic dermatitis (AD) in southern Chinese Han population.
Methods: The frequencies of the 13 known FLG gene single nucleotide polymorphism(SNPs), including 3321delA, 441delA, 1249insG, E1795X, S3296X, R501X, 2282del4, R2447X, S2889X, 7945delA, 3702delG, Q2417X, R4307X, were detected in a cohort of 50 AD patients and 100 control individuals using polymerase chain reaction (PCR) and DNA sequencing.
Results: FLG 3321delA and 441delA were detected in 14 (28%) and 6 (12%) AD patients, respectively.