Publications by authors named "Dong-xiao Zhuang"
Article Synopsis
- The study evaluates the effectiveness of advanced techniques like intraoperative MRI, awake craniotomy, and neurophysiologic monitoring for removing dominant-sided insular gliomas in patients.
- A total of 30 patients underwent surgery using guided methods to precisely locate critical brain areas, with improvements noted in the extent of tumor removal and overall safety.
- Results showed that these combined methods increased the extent of resection and reduced the chances of permanent language and motor deficits, making them beneficial for maximal safe tumor removal.
OBJECT The extent of resection is one of the most essential factors that influence the outcomes of glioma resection. However, conventional structural imaging has failed to accurately delineate glioma margins because of tumor cell infiltration. Three-dimensional proton MR spectroscopy ((1)H-MRS) can provide metabolic information and has been used in preoperative tumor differentiation, grading, and radiotherapy planning.
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- Genetic mutations are important for diagnosing and treating glioblastoma multiforme (GBM), but the diversity of mutations within a single tumor can complicate personalized treatment.* -
- The study analyzed 33 samples from 7 GBM patients using advanced techniques to identify 53 mutations across 27 genes, including some novel ones, showing that most mutations were unique to individual samples.* -
- Findings indicated that while certain mutations are associated with tissue characteristics, they don't consistently change based on the presence of major mutations, suggesting that single biopsy samples may not provide a complete genetic picture of GBM.*
Localizing hand motor area using resting-state fMRI: validated with direct cortical stimulation.
Acta Neurochir (Wien)
December 2014
Background: Resting-state functional magnetic resonance imaging (R-fMRI) is a promising tool in clinical application, especially in presurgical mapping for neurosurgery. This study aimed to investigate the sensitivity and specificity of R-fMRI in the localization of hand motor area in patients with brain tumors validated by direct cortical stimulation (DCS). We also compared this technique to task-based blood oxygenation level-dependent (BOLD) fMRI (T-fMRI).
View Article and Find Full Text PDFBackground: Intraoperative magnetic resonance imaging (iMRI) dates back to the 1990s and has been successfully applied in neurosurgery but they were low-field iMRI (< 1.0T). This paper reports the clinical experience with a 3T iMRI-integrated neurosurgical suite in Huashan Hospital, Shanghai, China.
View Article and Find Full Text PDFBackground: Glioma surgery in eloquent areas remains a challenge because of the risk of postoperative motor deficits.
Objective: To prospectively evaluate the efficiency of using a combination of diffusion tensor imaging (DTI) tractography functional neuronavigation and direct subcortical stimulation (DsCS) to yield a maximally safe resection of cerebral glioma in eloquent areas.
Methods: A prospective cohort study was conducted in 58 subjects with an initial diagnosis of primary cerebral glioma within or adjacent to the pyramidal tract (PT).
As a promising noninvasive imaging technique, functional MRI (fMRI) has been extensively adopted as a functional localization procedure for surgical planning. However, the information provided by preoperative fMRI (pre-fMRI) is hampered by the brain deformation that is secondary to surgical procedures. Therefore, intraoperative fMRI (i-fMRI) becomes a potential alternative that can compensate for brain shifts by updating the functional localization information during craniotomy.
View Article and Find Full Text PDFObjectives: To evaluate preliminary clinical experience for combining awake craniotomy and intraoperative language brain mapping within the integrated 3.0 T intraoperative magnetic resonance imaging (iMRI) suite.
Methods: From December 2010 to April 2011, 11 right hand-dominant patients with left glioma were involved in, or adjacent to, eloquent cortex was carried out awake craniotomies with cortical stimulation within an integrated 3.
Objective: To report the preliminary experience in clinical application of 3.0 T intraoperative magnetic resonance imaging (iMRI) neuronavigation system in China.
Methods: From September 2010 to March 2011, a consecutive series of 122 patients with intracranial lesions underwent operations in guidance with 3.
Article Synopsis
- * Recent advancements in surgical techniques and supplements for glioma surgery have emerged in China, analyzed through a comprehensive review of existing studies from multiple databases.
- * Current practices emphasize not just tumor removal, but also the patient's postoperative quality of life and neurofunctional status, aiming for a balance between survival and well-being.
Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle has been identified as a novel and distinctive type of primary central nervous system neoplasm. In this report, we present a case with RGNT arising from the right cerebellar hemisphere. A 30-year-old female patient complained of headache for a five-year duration.
View Article and Find Full Text PDFObjective: To evaluate the applicability of low-field intraoperative magnetic resonance imaging (iMRI) during transsphenoidal surgery of pituitary macroadenomas.
Methods: Fifty-five transsphenoidal surgeries were performed for macroadenomas (modified Hardy's Grade II-IV) resections. All of the surgical processes were guided by real-time updated contrast T1-weighted coronal and sagittal images, which were acquired with 0.