Effects of amoxicillin dosage on cure rate, gut microbiota, and antibiotic resistome in vonoprazan and amoxicillin dual therapy for Helicobacter pylori: a multicentre, open-label, non-inferiority randomised controlled trial.

Background: Vonoprazan and amoxicillin (VA) dual therapy as a mainstream Helicobacter pylori regimen has gained momentum worldwide, but the optimum dosages remain unclear. We aimed to compare the efficacy and safety of VA dual therapy with 2 g amoxicillin or 3 g amoxicillin, and to assess the short-term effects of therapy on the gut microbiota and antibiotic resistome.

Methods: We conducted an open-label, non-inferiority randomised controlled trial at 12 centres in China.

Differentiated expressed miRNAs in splenic monocyte induced by burn injury in mice.

To find potential biomarkers based on miRNA and their potential targets in splenic monocytes in burn-injured mice. Male Balb/c mice were subjected to sham or scalding injury of 15% total body surface area. Spenic CD11b+ monocytes were purified with magnetic beads.

Left atrial reservoir and pump function after catheter ablation with persistent atrial fibrillation: a two-dimensional speckle tracking imaging study.

Objective: By using ultrasound strain rate (SR) imaging to evaluate the left atrial (LA) reservoir and pump function after catheter ablation (CA) with persistent atrial fibrillation (PAF).

Methods: A total of 45 patients with PAF underwent echocardiography examination before and after ablation as well as during 6 months of follow-up. Peak SR was measured at each LA segment (septal, lateral, anterior, inferior and posterior) during systole (LAs) and late diastole (LAa).

Early detect left ventricular subclinical myocardial dysfunction in patients with systemic lupus erythematosus by a left ventricular pressure-strain loop.

Objective: Noninvasive myocardial work (MW) is a new technology which is based on strain after considering the load influence on myocardial deformation. We aimed to investigate the feasibility of quantitatively assessing left ventricular myocardial work (LVMW) in patients with systemic lupus erythematosus (SLE) using a left ventricular pressure-strain loop (LVPSL).

Methods: 76 patients with SLE were included in the study (A), further divided into two subgroups according to the presence of lupus nephritis (LN).

Characteristics of Heteroresistance in Gastric Biopsies and Its Clinical Relevance.

Background: Antimicrobial susceptibility testing (AST) plays a vital role in anti- treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and eradication failure.

Aims: To investigate the characteristics of heteroresistance in in gastric biopsies and investigate its clinical relevance.

Method: A total of 704 gastric biopsies were selected for 23S rRNA and gyrA gene sequencing, 470 isolates from these biopsies were selected for AST, and the clinical characteristics of the patients were reviewed.

Genotype profiles of from gastric biopsies and strains with antimicrobial-induced resistance.

Background And Aims: The genotypic method could significantly shorten the time needed to obtain antibiotic susceptibility data for . The aim of this study was to explore the profile of from gastric biopsies and strains with antibiotic-induced resistance.

Methods: A total of 124 gastric biopsies were used to perform gene sequencing and to perform bacterial culture and susceptibility testing.

Mechanism study on co-processing of water-based drilling cuttings and phosphogypsum in non-autoclaved aerated concrete.

The feasibility of coordinated use of water-based drilling cuttings (WDC), fly ash, and phosphogypsum (PG) as raw materials for the preparation of WDC non-autoclaved aerated concrete (WNAAC) was evaluated by laboratory experiment. The results showed that the pozzolanic reaction of the multi-component cementitious system containing 40% (in mass) of WDC is significantly promoted. Newly formed C-S-H gel and ettringite with the uniform distribution of fibrous and flake-like shape occur, presenting a denser and interlock microstructure.

Characteristics of antibiotic resistance: data from four different populations.

Aims: To describe the characteristics of () antibiotic resistance in clinical isolates from four populations.

Methods: In total, 1463 strains were examined for antibiotic resistance. Among these strains, 804 were isolated from treatment-naïve adults, 133 from previously treated adults, 100 from treatment-naïve children and 426 from a population who participated in a health survey (age ≥ 40 years).

An effective treatment method for phosphogypsum.

Phosphogypsum (PG) accumulation occupies huge amounts of land resources and results in serious environmental risks. A new recycling product, the phosphogypsum embedded filler (PGEF) made with calcination-modified phosphogypsum, was developed. The preparation process, hydration mechanism of PG, basic physical performances, environmental safety, engineering application, and cost analysis of the PGEF were studied.

An effective treatment method for shale gas drilling cuttings solidified body.

The exploration and production of shale gas technology provides a way for utilization of clean fuels. However, during the exploration process of shale gas, enormous amount of drilling cutting was generated and had to be solidified and landfilled. So the accumulation of shale gas drilling cutting solidified body (SGDS)causes severe land resource misuse and environmental complications.

Series of Lanthanide-Mercury Compounds with Three-Dimensional Structures: Rational Preparation, Structures and Properties.

Three novel Ln-Hg complexes [Ln(HO)(μ-IA)HgBr] (Ln = Pr (1), Nd (2), and Er (3); HIA is isonicotinic acid) are synthesized and characterized. They feature three-dimensional (3-D) motifs. Solid-state UV/vis diffuse reflectance spectroscopy found that their band gaps are 4.

Prognostic value of total tumor volume in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.

Background: Few studies have evaluated the prognostic value of total tumor volume (TTV), which reflects both the primary tumor volume and nodal tumor volume, in NPC. Furthermore, the relationship between TTV and survival remains unknown. The purpose of this study was to evaluate the prognostic value of TTV in patients with NPC treated with intensity-modulated radiation therapy (IMRT).

[Prevalence of Helicobacter pylori cagA, vacA, and iceA genotypes in children with gastroduodenal diseases].

Objective: To investigate the prevalence of cagA, vacA, and iceA genotypes in the isolated strains of Helicobacter pylori (H.pylori) from children with gastroduodenal diseases in Jiangxi, China, as well as the association between cagA, vacA, and iceA genotypes and the type of gastroduodenal diseases.

Methods: The samples of gastric antral mucosa were collected from 316 children with gastroduodenal diseases in Jiangxi, and a total of 107 strains of H.

The internalization of Helicobacter pylori plays a role in the failure of H. pylori eradication.

Background: Helicobacter pylori (H. pylori) internalization involves invasion of cells by the bacterium. Several studies have shown that H.

Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro.

Aim: To investigate the inhibitory effects and mechanism of high mobility group box (HMGB)1 A-box in lipopolysaccharide (LPS)-induced intestinal inflammation.

Methods: Overexpression of HMGB1 A-box in human intestinal epithelial cell lines (SW480 cells) was achieved using the plasmid pEGFP-N1. HMGB1 A-box-overexpressing SW480 cells were stimulated with LPS and co-culturing with human monocyte-like cell lines (THP-1 cells) using a Transwell system, compared with another HMGB1 inhibitor ethyl pyruvate (EP).

Photophysical and electrochemical properties of a dysprosium-zinc tetra(4-sulfonatophenyl)porphyrin complex.

A dysprosium-zinc porphyrin, [DyZn(TPPS)H3O]n (1) (TPPS = tetra(4-sulfonatophenyl)porphyrin), was prepared through solvothermal reactions and structurally characterized by single-crystal X-ray diffraction analyses. Complex 1 features a three-dimensional (3-D) porous open framework that is thermally stable up to 400 °C. Complex 1 displays a void space of 215 Å(3), occupying 9.

Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy?

Background: Intensity-modulated radiation therapy (IMRT) has represented a technical milestone that has facilitated the clinical implementation. The purpose of this study was to evaluate the prognostic value of maximum primary tumor diameter (MPTD) in patients with nasopharyngeal carcinoma (NPC) treated using IMRT.

Methods: Five-hundred and sixty-six patients with non-metastatic, histologically-confirmed NPC were retrospectively reviewed.

Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection.

Aim: To evaluate the efficacy of furazolidone-based triple and quadruple therapy in eradicating Helicobacter pylori (H. pylori) in a multi-center randomized controlled trial.

Methods: A total of 720 H.

A modified decision tree algorithm based on genetic algorithm for mobile user classification problem.

In order to offer mobile customers better service, we should classify the mobile user firstly. Aimed at the limitations of previous classification methods, this paper puts forward a modified decision tree algorithm for mobile user classification, which introduced genetic algorithm to optimize the results of the decision tree algorithm. We also take the context information as a classification attributes for the mobile user and we classify the context into public context and private context classes.

Primary tumor regression speed after radiotherapy and its prognostic significance in nasopharyngeal carcinoma: a retrospective study.

Background: To observe the primary tumor (PT) regression speed after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) and evaluate its prognostic significance.

Methods: One hundred and eighty-eight consecutive newly diagnosed NPC patients were reviewed retrospectively. All patients underwent magnetic resonance imaging and fiberscope examination of the nasopharynx before RT, during RT when the accumulated dose was 46-50 Gy, at the end of RT, and 3-4 months after RT.

[Effect of tube voltage on digital chest radiograph for phantom and occupational exposed workers].

Objective: To explore the image quality of different tube voltage on digital chest radiograph for contrast detail phantom (CDRAD2.0) and occupational exposed workers.

Methods: The CDRAD2.

[Effect of digital radiography processing parameters on digital chest radiograph for occupational exposed workers].

Objective: To investigate the effect of different processing parameters of digital radiography (DR) on the image quality of digital chest radiograph in dust-exposed workers.

Methods: One hundred and five dust-exposed workers underwent both high-KV radiography and DR to obtain chest radiographs; the image processing parameters were set by the conventional processing method for digital chest radiograph (method A) and the processing method based on the special requirements of occupational diseases (method B). With the high-KV chest radiograph as the reference, the image qualities at 10 anatomic sites of DR image were graded.

Prognostic significance of maximum primary tumor diameter in nasopharyngeal carcinoma.

Background: To evaluate the prognostic value of maximum primary tumor diameter (MPTD) in nasopharyngeal carcinoma (NPC).

Methods: Three hundred and thirty-three consecutive, newly-diagnosed NPC patients were retrospectively reviewed. Kaplan-Meier analysis and the log-rank test were used to estimate overall survival (OS), failure-free survival (FFS), distant metastasis-free survival (DMFS) and local relapse-free survival (LRFS).

[Temporal and spatial distribution of particulate organic carbon in the Yellow Sea and East China Sea in spring].

Based on the data from cruises that carried out in the Yellow Sea and East China Sea from April to May, 2009, the temporal and spatial distributions of the particulate organic carbon (POC) were analyzed. And the sources of POC were further discussed according to the chlorophyll a (Chl-a) and C/N. The results showed that the concentration of POC in the Yellow Sea and East China Sea ranged from 24.