Mutations in MC4R facilitate the angiogenic activity in patients with orbital venous malformation.

The detailed molecular mechanism of orbital venous malformation (OVM) is still not clear. Using whole exome sequencing, 4 types of melanocortin 4 receptor (MC4R) mutation were detected in 7 of 27 patients with OVM, and all types of MC4R mutations resulted in the upregulation of MC4R expression. study indicated that MC4R has impacts on the proliferation, cell cycle, migration, and tube formation of the endothelial cells.

Poly (ADP-ribose) polymerase-1 (PARP-1) in Chinese patients with Graves' disease and Graves' ophthalmopathy.

We aimed to evaluate the genetic variation of poly (ADP-ribose) polymerase-1 (PARP-1) as risk factor in development of Graves' disease (GD) and Graves' ophthalmopathy (GO) among Chinese individuals. Patients with confirmed diagnosis of GD or healthy individuals with no clinical symptoms of hyperthyroiditis were enrolled at the Department of Ophthalmology, Tianjin First Center Hospital, China. Genetic polymorphism was studied in plasma DNA samples of subjects by polymerase chain reaction of restriction fragment length polymorphism to confirm our hypothesis.

[The clinical analysis of cranio-orbital communicating tumors].

Objective: To investigate the clinical manifestations, imageological features, surgical approaches and prognosis of cranio-orbital communicating tumors.

Methods: The retrospective analysis was performed in the 22 patients of cranio-orbital communicating tumors in the past three years. CT and MRI examinations were applied in all cases.

[Imaging feature and clinical histological analysis of 12 adenoid cystic carcinoma of the lacrimal gland].

Objective: To study the imaging and histologic features of adenoid cystic carcinoma (ACC) of the lacrimal gland.

Methods: It was a retrospective case series study. Twelve patients with ACC of the lacrimal gland were surgically treated in Tianjin First Center Hospital from September 2009 to November 2011.

[Clinical features and therapy of benign lymphoepithelial lesion].

Objective: To report the clinical features of benign lymphoepithelial lesion and to further characterize recommendations for its therapy strategy.

Methods: It was a retrospective case sires. Retrospective analyze the clinical characteristics, imaging features, pathological manifestation and the treatment effect from the clinical materials of 9 cases of patients with benign lymphoepithelial lesion presenting to Tianjin Eye Hospital from Jan 2006 to Dec 2007.

[Analysis of treatment and prognosis of orbital adenoid cystic carcinoma].

Objective: To summarize the treatment outcomes of orbital adenoid cystic carcinoma and to evaluate prognostic factors.

Method: A retrospective case series study was performed on 75 patients with orbital adenoid cystic carcinoma treated from 1991 to 2006.

Results: The 2- and 5-year local recurrence rate of solid type orbital adenoid cystic carcinoma was significantly higher than that of the adeno-tubiform type [2-year, 85% (17/20) vs 23.