Publications by authors named "Dong-ki Kim"

Background: Glomerular diseases encompass a group of kidney diseases that may share common gene expression pathways. Here, we analyzed glomerular-specific gene expression profiles across various glomerular diseases.

Methods: We performed spatial transcriptomic profiling using formalin-fixed paraffin-embedded kidney biopsy specimens of controls and patients with five types of glomerular diseases using the GeoMx Digital Spatial Profiler.

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Purpose: Chronic kidney disease (CKD) causes detrimental systemic effects, including inflammation or apoptosis, which lead to substantial morbidity and mortality. However, the causal effect of reduced kidney function on systemic proteomic signatures is incompletely understood.

Methods: We performed an integrated Mendelian randomization (MR) and observational analyses to identify the causal association between kidney function and plasma protein levels, based on 1815 plasma protein profiles in 50,407 UK Biobank participants and the CKDGen Phase 4 genome-wide association study (GWAS) meta-analysis for the genetic instruments of eGFR.

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Using a lithium (Li) metal anode is essential for high-energy batteries, however, dendritic Li growth is unavoidable during Li plating and stripping processes. Strategically, a porous carbon structure derived from a metal-organic framework is suggested for directly storing metallic Li, although problems still exist with plating Li from the core to the surface and with stripping Li from the surface. Herein, we strategically utilize the carbon structure of zeolitic imidazolate framework-8 as an anode and replace the inactive residual Zn with Ag through galvanic displacement.

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Tetrodotoxin blocks voltage-gated sodium channels, which are responsible for the initiation and propagation of action potentials. Impairment of action potential conduction in myocardial cells affects the cardiac conduction system and can influence electrocardiogram output. In this retrospective study, we investigated whether tetrodotoxin poisoning prolong the PR, QRS and QTc intervals, which might be used as prognostic indices of respiratory failure after tetrodotoxin poisoning.

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Background: It remains unclear whether the incidence of post-operative acute kidney injury (PO-AKI) has been reduced despite the recent emphasis on its early recognition and prevention in clinical practice. We aimed to investigate the trend in the incidence of PO-AKI and to identify the associated factors affecting its changes.

Methods: We gathered clinical data from patients who underwent non-cardiac major surgeries at three referral hospitals from 2005 to 2020.

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Graphene quantum dots (GQDs) have received much attention for their biomedical applications, such as bioimaging and drug delivery. Additionally, they have antioxidant and anti-inflammatory properties. We used GQDs to treat renal fibrosis and confirmed their ability to protect renal cells from excessive oxidative stress in vitro and in vivo.

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Background: Obstructive sleep apnea (OSA) is a sleep disorder associated with an increased risk of cardiovascular and metabolic complications. Albuminuria, an early marker of kidney damage, is a proposed risk factor for OSA and its adverse outcomes. The study explored the association between OSA and albuminuria in Korean adults.

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Podocyte injury and proteinuria in glomerular disease are critical indicators of acute kidney injury progression to chronic kidney disease. Renal mitochondrial dysfunction, mediated by intracellular calcium levels and oxidative stress, is a major contributor to podocyte complications. Despite various strategies targeting mitochondria to improve kidney function, effective treatments remain lacking.

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Rationale & Objective: Recipients of kidney allografts are at risk of osteoporotic fractures (OF), but the association of OF with transplant patient outcomes remains uncertain due to common coexisting risks and complex medical conditions. This study sought to assess whether the overall incidences of OF among recipients of kidney allografts compared to that of patients receiving maintenance dialysis for kidney failure.

Study Design: A national retrospective cohort study.

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Background: Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status.

Methods: We used data from the U.S.

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Article Synopsis
  • The study examines the progression of acute kidney injury (AKI) to acute kidney disease (AKD) or chronic kidney disease (CKD) and aims to identify biomarkers and personalized treatments.
  • It involves a collaboration among eight Korean hospitals, where they gathered data from around 1,500 patients undergoing continuous kidney replacement therapy, using a combination of historical and ongoing patient information.
  • The research intends to develop an AI model to predict patient outcomes and guide tailored treatment plans, ultimately providing insights for better management and prevention of kidney-related diseases.
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This study aims to investigate the association between serum calcium levels and acute coronary syndrome (ACS) risk, examining whether this relationship differs by sex, given the known differences in calcium metabolism and hormonal influences between males and females. Utilizing the Korean Genome Epidemiology Study (KoGES) prospective cohort data, our primary exposure variables were serum calcium level and sex. The incidence of ACS served as the main outcome of interest.

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Periodontitis is associated with elevated C-reactive protein (CRP) levels. Although the coexistence of periodontitis and elevated CRP levels may heighten the risk of mortality, previous studies have not confirmed their synergistic effect. Understanding this interaction is crucial for identifying potential interventions to reduce mortality risk in individuals with periodontitis.

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Background: Hormone replacement therapy (HRT) is recommended for alleviating vasomotor symptoms or preventing bone loss in postmenopausal women. This study aimed to investigate the impact of hormone replacement therapy on major adverse cardiovascular events, kidney failure, and mortality in women with chronic kidney disease (CKD).

Methods: This population-based cohort study analyzed data from the National Cancer Screening Program and the national health examination of South Korea.

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  • Immunoglobulin A nephropathy (IgAN) is a significant cause of end-stage kidney disease (ESKD), and while the International IgA Nephropathy Prediction Tool (IIgAN-PT) exists for prognosis, there's a need to enhance prediction accuracy using machine learning (ML).
  • A study involving 4,425 IgAN patients analyzed various ML models, including different versions of the CatBoost model, to predict ESKD and renal function using clinical and pathological data; these were compared to the performance of the IIgAN-PT.
  • Results showed that while ML models performed well in predicting kidney outcomes, they did not surpass the IIgAN-PT's performance, indicating that current ML methods
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  • In-depth investigation into medical costs before and after biopsies for kidney diseases in South Korea is essential for understanding risks and outcomes.
  • The study analyzed data from 1,390 patients diagnosed with glomerulonephritis (GN), tubulointerstitial nephritis (TIN), and acute tubular necrosis (ATN) between 2012 and 2018, linking clinical data to national medical claims.
  • Findings indicate that medical costs usually rise post-biopsy for most kidney diseases, with increased rates of serious health events noted in certain disease categories, highlighting critical epidemiological insights.
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  • * Five key proteins were isolated, with transgelin highlighted as a significant candidate that increases as fibrosis advances; its gene expression was notably higher in advanced stages of CKD.
  • * Transgelin may serve as a promising biomarker and therapeutic target for CKD fibrosis, potentially helping to modulate oxidative stress and mitochondrial dysfunction.
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  • STAT3 is a protein that helps control the immune response and is important during kidney injuries caused by inflammation.
  • Researchers tested a drug called Stattic to see if it could help with kidney damage and inflammation in mice.
  • The results showed that Stattic reduced kidney injury and inflammation, helping certain types of immune cells to work better in healing the kidneys.
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Key Points: This study, the sole randomized trial of its kind, proposes guidelines for fluid balance management in continuous KRT (CKRT) patients using bioimpedance. Despite this, bioimpedance analysis–guided volume management did not influence the proportion of patients achieving estimated euvolemia at 7 days into CKRT. Further investigation is needed to assess whether bioimpedance analysis guidance can facilitate rapid fluid removal in the early phase of CKRT for patients with AKI.

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Objectives: Our study aimed to investigate both the independent and combined effects of secondhand smoking (SHS) and alcohol intake on the occurrence of stroke.

Methods: Utilizing the Korean Genome Epidemiology Study prospective cohort data, our primary exposure variables were SHS exposure and alcohol intake. The occurrence of stroke served as the main outcome of interest.

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  • A study explored the mechanisms behind diabetic kidney disease (DKD) in type 2 diabetes patients using advanced mass spectrometry techniques in two cohorts from different continents.
  • The research identified urinary biomarkers linked to kidney disease progression, focusing on protein groups that indicated higher risks of worsening kidney function.
  • Results revealed that certain urine proteins related to the complement system were strongly associated with faster disease progression, supporting their potential role as biomarkers in DKD assessment.
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The bidirectional effect of hyperuricemia on chronic kidney disease (CKD) underscores the importance of hyperuricemia as a risk factor for CKD. We evaluated the effect of hyperuricemia on the presence and development of CKD after considering genetic background by calculating polygenic risk scores (PRSs). We employed genome-wide association study summary statistics-excluding the United Kingdom Biobank (UKB) datasets among published CKD Gen Consortium papers-to calculate the PRSs for CKD in white background subjects.

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  • ECPR is a special medical treatment for people who have serious heart problems, but only about 29% of them leave the hospital alive.
  • Researchers studied how kidney injuries, called AKI, might help predict if patients will survive or have good brain function after ECPR.
  • They found that patients with AKI had much higher rates of dying in the hospital and worse brain outcomes compared to those without AKI, showing that AKI can help doctors know who might have a better or worse chance of recovering.
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Aim: We validated the prognostic performance of neuron-specific enolase (NSE) according to the recommended values in cardiac arrest (CA) survivors.

Methods: We analyzed the data of adult CA survivors who underwent targeted temperature management between January 2014 and December 2020. We measured the NSE level 48 h and 72 h after CA.

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