Publications by authors named "Dong-hong Cui"
Article Synopsis
- * Researchers found higher mRNA levels of RNF4 and SART3 in SCZ patients compared to controls and identified specific genetic variants (SNPs) related to increased SCZ risk.
- * Experiments suggested that SART3 regulates RNF4 expression through ubiquitination, indicating a potential shared mechanism influencing SCZ risk, which could help in developing new treatment strategies.
[Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2010
Objective: To investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein(CREB1) gene and major depressive disorder (MDD).
Methods: We recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise SNP linkage disequilibrium(LD) and haplotype-based TDT were performed.
A lymphocyte cDNA library of normal human was constructed in order to obtain specific gene and prepare lymphocyte gene chips to detect the relative genes between psychiatric diseases and immunity. The lymphocyte was abstracted from fresh normal human blood and cultured in vitro. Total RNA of lymphocyte was extracted from the cultured cells and then mRNA was extracted further.
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