Publications by authors named "Dong-dong Tong"
HIF-1α is involved in the carcinogenesis and progression of multiple types of cancer. However, the precise role of HIF-1α is unclear in multiple myeloma. Through the qRT-PCR and CCK-8 assays, we demonstrated that silencing the expression of HIF-1α and Mcl-1, MM proliferation can be decreased and apoptosis can be induced.
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- MeCP2 is found to be significantly upregulated in breast cancer tissues and its high expression is linked to poorer overall survival rates.
- Knockdown of MeCP2 in breast cancer cells resulted in reduced cell growth, migration, and increased apoptosis, indicating its role in promoting cancer cell survival and proliferation.
- The study identifies that MeCP2 represses the transcription of RPL11 and RPL5 by binding to their promoters, and these proteins help prevent the degradation of the tumor suppressor P53, thus playing a critical role in cancer progression.
Background: The aims of this study were to determine the best suited magnetic resonance imaging scanning plane, scanning sequence, and imaging modality for the evaluation of the temporomandibular joint (TMJ) and quantitatively assess the relationship of articular disk position to condyle position.
Methods: One hundred four TMJs in 52 symptom-free heads were examined by magnetic resonance imaging. The best scanning plane, scanning sequence, and scanning parameter were determined according to the imaging time and image quality.
Background: MicroRNAs play important roles in the development and progression of various cancers. Recent studies have shown that miR-638 was downregulated in several tumors; however, its role in gastric cancer (GC) has not been investigated in detail.
Aims: The purpose of this study was to determine the role of miR-638 and to elucidate its regulatory mechanism in GC.
[Expression and significance of P75 neurotrophin receptor in oral squamous cell carcinoma].
Shanghai Kou Qiang Yi Xue
August 2011
Article Synopsis
- This study explores the role of P75NTR in oral squamous cell carcinoma (OSCC) to determine its potential as a prognostic indicator and a marker for cancer stem cells.
- Using immunohistochemical methods, researchers analyzed P75NTR expression in a tongue cancer cell line and tissue samples from OSCC patients, comparing them to normal and peri-carcinoma tissues.
- Results show high P75NTR expression in a majority of OSCC cases, with a significant association with tumor stage and lymph node metastasis, suggesting it can help predict OSCC prognosis, but more research is needed to understand its exact role in cancer biology.