Publications by authors named "Dong-Yun Lee"

Article Synopsis
  • Helicobacter pylori (HP) is linked to gastritis and peptic ulcers, prompting a study on how probiotics Lactococcus lactis P135 and Bifidobacterium longum P142 can inhibit HP growth and the inflammatory response.
  • Both probiotics significantly reduced HP levels, inflammation markers, and also improved symptoms like depression and cognitive impairment in mice suffering from HP-induced conditions.
  • The administration of these probiotics resulted in beneficial changes in gut microbiota, with a decrease in harmful bacteria and an increase in beneficial ones, suggesting they could help reduce gut and neuroinflammation, thereby improving overall health.
View Article and Find Full Text PDF

Purpose: The K-FRAIL scale is a Korean version of the aging questionnaire that allows screening and diagnosis of easily observable aging in the elderly through a simple self-answer questionnaire. The objective of this study was to examine the relation between fraility and clinical symptoms of the lower urinary tract in elderly men using the K-FRAIL scale.

Materials And Methods: A prospective study was conducted on 100 patients who underwent urological examination at our hospital from January 2021 to December 2021.

View Article and Find Full Text PDF

Insomnia (sleeplessness) is a potential symptom of stress-induced depression/anxiety (DA), which induces TNF-α expression. Therefore, this study aimed to examine the effect of () P72, isolated as a strain suppressing lipopolysaccharide-induced expression of TNF-α in Caco2 cells, on DA and insomnia in immobilization stress (IS)- or cultured fecal microbiota (cFM)-treated mice. Oral administration of live or heat-killed P72 (hP72) reduced IS- or cFM-induced DA-like behaviors.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the relationship between white matter hyperintensities (WMH) on brain MRIs and cognitive decline, focusing on how these factors may differ between sexes.
  • Researchers analyzed 713 participants aged 49-89, assessing the effects of modifiable risk factors for WMH and examining their impact on long-term dementia outcomes.
  • Findings suggest that age and type 2 diabetes significantly influence WMH volume, with stronger correlations identified in females, and that WMH burden is linked to worse dementia outcomes over time specifically in females.
View Article and Find Full Text PDF

In this study, we address the persistent challenge of providing adequate oxygen to transplanted cells by introducing a respiratoid biosystem. Central to our strategy is the chloroplast-transit-peptide (CTP), crucial for optimal oxygenation. Through conjugation of CTP with alginate, we achieve stabilization of chloroplast structure.

View Article and Find Full Text PDF
Article Synopsis
  • This study examined how baseline and interim PET/CT scans can predict the progression-free survival (PFS) of patients with advanced neuroendocrine tumors (NET) undergoing peptide receptor radionuclide therapy (PRRT).
  • A total of 24 patients were analyzed, where key PET parameters, including changes in tumor volume (WTV) and receptor expression (TRE), were linked to outcomes; higher decreases in these measures indicated a shorter PFS.
  • The findings suggest that monitoring changes in WTV and TRE from PET/CT scans can be useful tools for predicting how well patients respond to PRRT based on their individual tumor characteristics.
View Article and Find Full Text PDF
Article Synopsis
  • Breast cancer is the most common cancer in women of reproductive age, and chemotherapy often leads to the need for fertility preservation (FP), with established methods like embryo, oocyte, or ovarian tissue cryopreservation available.
  • A study involving 1623 women from multiple countries showed a consistent increase in FP referrals, with 38.7% of referred women undergoing FP, particularly oocyte cryopreservation, which became more popular over the years.
  • The findings highlight growing awareness and utilization of FP among young breast cancer patients, but they also point out significant regional differences that can inform policy decisions regarding FP care.
View Article and Find Full Text PDF
Article Synopsis
  • Depression frequently co-occurs with adult ADHD, and combining methylphenidate with SSRIs is a common treatment, but safety data for this combo in adults is limited.
  • The study analyzed data from a nationwide claims database in South Korea, focusing on adults diagnosed with both ADHD and depression who were prescribed methylphenidate.
  • A total of 17,234 adults were studied, and results showed no significant safety differences between those taking the combination of SSRIs with methylphenidate compared to those on methylphenidate alone.
View Article and Find Full Text PDF
Article Synopsis
  • - This study aimed to better understand the role of pre-operative dual-time-point [F]FET PET imaging in characterizing adult-type diffuse gliomas, correlating imaging results with next-generation sequencing data to enhance surgical planning.
  • - Researchers recruited 76 adult patients suspected of having glioma, performing PET scans at two time points after [F]FET injection, and analyzed tumor uptake values and changes alongside histopathological classification and genetic mutations.
  • - Results showed that glioma patients with CDKN2A/B gene loss exhibited significantly higher PET imaging values, indicating more aggressive tumors, while those with PIK3CA mutations showed greater changes in uptake, highlighting the importance of genetic factors in imaging outcomes.
View Article and Find Full Text PDF

The role of torso computed tomography (CT) in evaluating body composition has been unexplored. This study assessed the potential of low-dose torso CT from positron emission tomography (PET)/CT for analyzing body composition and its relation to muscle strength. We retrospectively recruited 384 healthy Korean adults (231 men, 153 women) who underwent torso F-FDG PET/CT, bioelectrical impedance analysis (BIA), and muscle strength tests (handgrip strength [HGS] and knee extension strength [KES]).

View Article and Find Full Text PDF
Article Synopsis
  • A study analyzed how COVID-19 affected psychotropic drug prescriptions among individuals with depressive and anxiety disorders across six countries from 2016 to 2020.
  • Researchers used electronic medical records to observe trends in prescribing rates during the pandemic, noting an initial increase followed by a decline towards pre-pandemic levels.
  • Most affected patients were aged 45-64, with a significant number of females diagnosed, but data on ethnicity was not collected.
View Article and Find Full Text PDF

Soybean alleviates cognitive impairment. In our preparatory experiment, we found that dry-heat (90 °C for 30 min)-processed soybean embryo ethanol extract (hSE) most potently suppressed lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α expression in BV2 cells among dry-heat-, steaming-, and oil exclusion-processed soybean embryo ethanol extracts (SEs). Heat processing increased the absorbable soyasaponin Bb content of SE.

View Article and Find Full Text PDF
Article Synopsis
  • Researchers developed a new imaging technique using SPECT/CT to measure bone turnover at the individual vertebra level in postmenopausal women with osteoporosis.
  • The study found that while the standardized uptake value (SUV) positively correlated with bone mineral density (vBMD), the density-adjusted SUV (dSUV) showed a negative correlation, indicating that lower bone density is linked to higher turnover rates.
  • This novel approach could improve the precision of osteoporosis assessments and lead to more personalized treatment strategies.
View Article and Find Full Text PDF

Purpose: Despite the effectiveness of 177 Lu-based peptide receptor radionuclide therapy in treating metastatic neuroendocrine tumors (NETs), disease progression posttreatment remains a significant challenge. Targeted alpha therapy (TAT) has emerged as a promising option for patients experiencing such progression. This study aims to assess the therapeutic efficiency and toxicity of TAT in patients with metastatic NET through a meta-analysis.

View Article and Find Full Text PDF

The mass production of high-quality graphene is required for industrial application as a future electronic material. However, the chemical vapor deposition (CVD) systems previously studied for graphene production face bottlenecks in terms of quality, speed, and reproducibility. Herein, we report a novel conveyor CVD system that enables rapid graphene synthesis using liquid precursors.

View Article and Find Full Text PDF

Nasal valve dysfunction can substantially impact nasal airflow and overall quality of life. This review provides a comprehensive examination of nasal valve dysfunction, including its mechanisms, classification, and surgical management. The nasal valves include internal and external valves, each of which plays a crucial role in regulating nasal airflow.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzed 268 newly diagnosed patients with primary central nervous system lymphoma (PCNSL) to assess the value of 18F-FDG-PET/CT scans for prognostication and evaluating treatment response from 2006 to 2020.
  • Results showed that patients with a high baseline total metabolic tumor volume (TMTV ≥17.0 cm³) had significantly shorter overall survival (OS) compared to those with lower values.
  • Additionally, post-treatment metabolic responses indicated by 18F-FDG-PET/CT were strong predictors of progression-free survival (PFS) and OS, contrasting with MRI results that showed no significant correlation.
View Article and Find Full Text PDF

Conventional alginate microcapsules are widely used for encapsulating therapeutic cells to reduce the host immune response. However, the exchange of monovalent cations with divalent cations for crosslinking can lead to a sol-gel phase transition, resulting in gradual degradation and swelling of the microcapsules in the body. To address this limitation, we present a biocompatible and nondegradable epigallocatechin-3-gallate (EGCG)-based microencapsulation with ethylamine-bridged EGCG dimers (EGCG(d)), denoted as 'Epi-Capsules'.

View Article and Find Full Text PDF

Purpose: Patients with lower urinary tract symptoms (LUTS) often experience comorbid depression and anxiety, yet the mechanisms underlying this association remain incompletely understood. This prospective study aimed to investigate the relationship between depression, anxiety, and LUTS in men.

Materials And Methods: A prospective study was conducted with 350 male patients who underwent urologic examinations at our institution from January 2021 to December 2021.

View Article and Find Full Text PDF

Objectives: [F]Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a non-invasive imaging modality used in the differential diagnosis of splenic lesions, although ideal parameters and thresholds remain unclear. The present study evaluated the ability of [F]FDG PET/CT, including its visual and quantitative parameters, to differentiate between benign and malignant splenic lesions.

Methods: Patients who underwent [F]FDG PET/CT following the detection of splenic lesions on contrast-enhanced CT were retrospectively analysed.

View Article and Find Full Text PDF

Background: Hospital readmission is an important indicator of inpatient care quality and a significant driver of increasing medical costs. Therefore, it is important to explore the effects of postdischarge information, particularly from home healthcare notes, on enhancing readmission prediction models. Despite the use of Natural Language Processing (NLP) and machine learning in prediction model development, current studies often overlook insights from home healthcare notes.

View Article and Find Full Text PDF