Identification of the Potential Molecular Mechanism of Gene in Persistent Atrial Fibrillation.

Background: Transforming growth factor beta-induced protein (TGFBI, encoded by gene), is an extracellular matrix protein, widely expressed in variety of tissues. It binds to collagens type I, II, and IV and plays important roles in the interactions of cell with cell, collagen, and matrix. It has been reported to be associated with myocardial fibrosis, and the latter is an important pathophysiologyical basis of atrial fibrillation (AF).