Publications by authors named "Dong-Yan Bao"
[Effects of salvia miltiorrhiza injection on gentamicin-induced expression of nitric oxide synthase isoforms in guinea pig cochlea].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
May 2011
Article Synopsis
- The study aimed to evaluate how salvia miltiorrhiza injection (SM) impacts the expression of nitric oxide synthase (NOS) isoforms in guinea pigs exposed to gentamicin (GM), focusing on SM's protective effects against GM-induced hearing loss.
- Researchers divided 40 guinea pigs into four groups: a control group, a GM group, an SM group, and a GM plus SM group, measuring NOS expression and auditory thresholds using immunohistochemistry and auditory brainstem response (ABR) tests.
- Results indicated that the combination of GM and SM significantly reduced the expression of inducible NOS (iNOS) and improved ABR thresholds compared to the GM group, suggesting that SM protects against GM ot