Bioactive secondary metabolites isolated from the branches and leaves of Pittosporum pulchrum Gagnep.

Five new compounds, including two sesquiterpenoid glycosides (1 and 2), two monoterpenoid glycosides (3 and 4), and a quinovose ester (5), together with four known compounds (6-9) were isolated from branches and leaves of Pittosporum pulchrum Gagnep. Their structures were established by 1D and 2D NMR, HR-ESI-MS, IR and UV spectral analyses. This is the first time to investigate the chemical constituents of P.

Effect of Impact Velocity and Angle on Impact Wear Behavior of Zr-4 Alloy Cladding Tube.

In the pressurized water reactor nuclear power plant, 316L SS chips were captured by the support grid and continued to affect the Zr-4 cladding tube, causing the fuel rods to wear and perforate. In this work, a 60° acute angle cone of 316L SS was used to simulate the cyclic impact of debris on a Zr-4 alloy tube with different initial impact velocities and impact angles. Results showed that increasing the initial impact velocity will generate a wear debris accumulation layer with a wear-reducing effect, but also promote the extension and expansion of fatigue cracks, resulting in the delamination of Zr-4 alloy tubes.

[Foliar stable carbon isotope composition and water use efficiency of plant in the Karst seasonal rain forest.].

To enrich niche partition and species coexistence theory in karst seasonal rain forest, and provide reference for species selection and configuration for rocky desertification control, we exami-ned foliar stable carbon isotope composition (δC) and water use efficiency (WUE) of the representative species in different habitats and the same tree species in different habitats. The results showed that foliar δC value in karst seasonal rain forest ranged from -34.13‰ to -29.

[Analysis of Heavy Metal Pollution and Ecological Risk Assessment on Vegetation Leaves in Baoji City].

Using seven types of vegetation and seven heavy metals (Cr, Cu, Ni, Mn, Pb, Cd, and As), the present study explored the ability of accumulation and degree of contamination in the leaves of vegetation in Binhe Road. The results demonstrated a negative trend between vegetation height and heavy metal content of vegetation leaves, i.e.

PMLIV overexpression promotes TGF-β-associated epithelial-mesenchymal transition and migration in MCF-7 cancer cells.

The epithelial-mesenchymal transition (EMT) is a key event associated with metastasis and dissemination in breast tumor pathogenesis. Promyelocytic leukemia (PML) gene produces several isoforms due to alternative splicing; however, the biological function of each specific isoform has yet to be identified. In this study, we report a previously unknown role for PMLIV, the most intensely studied nuclear isoform, in transforming growth factor-β (TGF-β) signaling-associated EMT and migration in breast cancer.

Nicotinic Acetylcholine Receptors Mediate the Suppressive Effect of an Injection of Diluted Bee Venom into the GV3 Acupoint on Oxaliplatin-Induced Neuropathic Cold Allodynia in Rats.

Oxaliplatin, a platinum-based chemotherapy drug, often induces acute neuropathic pain, especially cold allodynia, even after a single administration. Subcutaneous injection of diluted bee venom (BV) into acupoints has been used to treat various pain symptoms in traditional oriental medicine. Although we previously demonstrated the suppressive effect of BV injection on oxaliplatin-induced cold allodynia in rats, its neurochemical mechanism remained unclear.

Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats.

Background: Oxaliplatin, an important chemotherapy drug for advanced colorectal cancer, often induces peripheral neuropathy, especially cold allodynia. Our previous study showed that bee venom acupuncture (BVA), which has been traditionally used in Korea to treat various pain symptoms, potently relieves oxaliplatin-induced cold allodynia in rats. However, the mechanism for this anti-allodynic effect of BVA remains poorly understood.

Effect of bee venom acupuncture on oxaliplatin-induced cold allodynia in rats.

Oxaliplatin, a chemotherapy drug, often leads to neuropathic cold allodynia after a single administration. Bee venom acupuncture (BVA) has been used in Korea to relieve various pain symptoms and is shown to have a potent antiallodynic effect in nerve-injured rats. We examined whether BVA relieves oxaliplatin-induced cold allodynia and which endogenous analgesic system is implicated.

A novel method for modifying AFM probe to investigate the interaction between biomaterial polymers (chitosan-coated PLGA) and mucin film.

A new method for modifying atomic force microscope (AFM) probe with polymer was proposed to estimate the interaction between Chitosan (CS)-coated poly (lactic-co-glycolic acid) (PLGA) polymer and mucin film. In this method, the mixture of polymers and its suitable volatile dissolvent were deposited on the AFM probe tip through a micropipette controlled by micromanipulator. After being dried, the polymer film forms on the probe tip.