Publications by authors named "Dong-Xing Guo"
Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of community-acquired respiratory tract infections (RTIs). We aimed to investigate the prevalence of M.
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- Endothelial nitric oxide synthase (eNOS) uncoupling contributes to endothelial dysfunction in atherosclerosis, and genistein is known to help prevent this condition but its effects on eNOS uncoupling hadn't been previously studied.
- In experiments using human umbilical vein endothelial cells (HUVECs) that were injured by oxidized low-density lipoprotein (ox-LDL), genistein was found to reduce the production of harmful superoxide and improve the balance of crucial compounds (BH4/BH2).
- The study concluded that genistein improves eNOS uncoupling through the activation of the sirtuin-1 pathway, suggesting a potential therapeutic role in managing atherosclerosis.
Background And Aims: Genistein, a principal component of soybean isoflavones, plays an important role in the prevention of atherosclerosis. However, the detailed mechanisms have not been fully investigated. The aims of this study were to evaluate the anti-atherosclerotic effect and investigate potential pharmacological mechanism of genistein.
View Article and Find Full Text PDFBackground: It is very important for the clinical management to test for minor HIV-1 resistance mutations accurately and sensitively. The conventional genotypic assays of HIV drug resistance detection based on sequencing can only discriminate the mutations which present in more than 20% - 30%. The aim of this study was to evaluate allele-specific real-time PCR (ASPCR) to detect the resistance-related mutations located at positions 103, 184 and 215.
View Article and Find Full Text PDF[Ultrastructural study on pharyngeal armature of seven species of sandflies in china by scanning electron microscopy].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
April 2004
Objective: To observe the ultrastructure of pharyngeal armature of 7 species of sandflies in China.
Methods: The pharyngeal armature of various sandflies were studied by scanning electron microscopy.
Results: The pharyngeal armature of sandfly consisted of pointed-teeth with various shape, number and arrangement among different species.