Publications by authors named "Dong-Xin Zhang"
Osteosarcoma (OS) is a type of tumor with high malignant behaviors. Increasing investigates have confirmed that long non-coding RNA HLA complex group 18 (lncRNA HCG18) acted as a tumor-promoting factor in multiple tumors. Nevertheless, the underlying mechanism of HCG18 on OS remains largely unclear.
View Article and Find Full Text PDFAim: Hepatocellular carcinoma (HCC) is common and causes many deaths worldwide. The aim of this study is to explore the mechanism by which long non-coding RNA FGD5-AS1 regulates HCC cell proliferation and stemness.
Methods: Tumor and normal adjacent tissues were harvested from HCC patients.
Background: XB130 is a recently discovered adaptor protein that is highly expressed in many malignant tumors, but few studies have investigated its role in hepatocellular carcinoma (HCC). Therefore, this study explored the relationship between this protein and liver cancer and investigated its molecular mechanism of action.
Methods: The expression of XB130 between HCC tissues and adjacent nontumor tissues was compared by real-time polymerase chain reaction, immunochemistry, and Western blotting.
Anti-apoptosis Effect of Decoy Receptor 3 in Cholangiocarcinoma Cell Line TFK-1.
Chin Med J (Engl)
January 2018
Background: Decoy receptor 3 (DcR3) is a protein with anti-apoptotic effect that belongs to the tumor necrosis factor receptor superfamily. DcR3 is highly expressed in a variety of malignant tumors including cholangiocarcinoma and its expression was found to be related to the clinical stage, the invasion, and the metastasis of the tumor. This in vitro study aimed to investigate the effect of downregulated expression of DcR3 on cell viability, cell apoptosis, and cell cycle in cholangiocarcinoma cell line TFK-1.
View Article and Find Full Text PDFHepatocellular carcinoma, one of the most common cancers, leads to mass mortality worldwide currently. However, the underlying mechanism of its oncogenesis remains to be elucidated. Here we identified that a long noncoding RNA, , was greatly upregulated in human hepatocellular carcinoma samples.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the outcomes of liver transplantation in patients with end-stage biliary disease (ESBD), defining the condition and assessing criteria for patient selection and surgical decisions.
- A total of 43 patients with various causes of ESBD were analyzed from two Chinese organ transplantation centers, focusing on demographic and clinical factors that could affect transplant outcomes.
- Results showed that patients with ESBD had lower MELD/PELD scores and more prior surgeries compared to end-stage liver disease (ESLD) patients, but they also experienced longer operation and intensive care times.
Background And Aims: Massive hepatectomy often leads to fatal liver failure because of a small remnant liver volume. The aim of this study was to investigate the potential mechanisms leading to liver failure.
Methods: Sprague-Dawley rats had performed a sham operation, 85 % partial hepatectomy (PH) or 90 % PH, and all had free access to water with or without supplemented glucose.