Publications by authors named "Dong-Xiang Zeng"
It has been reported that cyclin-dependent kinase like 3 (CDKL3) plays a crucial role in cell proliferation and migration in several cancers. However, the function of CDKL3 in triple-negative breast cancer (TNBC) is still unclear. In the present study, immunohistochemistry (IHC) was conducted to detect the CDKL3 expression.
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- * Female C57BL/6 mice were irradiated and then received hematopoietic stem cells from male BALB/c donors, with DLI given either IV or via IBM.
- * Results showed that IBM-DLI significantly reduced both the frequency and severity of GVHD compared to IV-DLI, with an increase in IL-4 levels and a decrease in IFN-gamma in the IV group.
[Influence of intra-bone marrow infusion of peripheral hematopoietic stem cells on graft-versus-host disease].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2007
Article Synopsis
- The study investigated the effectiveness of intra-bone marrow (IBM) infusion of allogeneic hematopoietic stem cells in reducing graft-versus-host disease (GVHD) in mice.
- Female C57BL/6 mice were exposed to total body irradiation and then received stem cells from mobilized male BALB/c mice, with results showing that the IBM group experienced significantly lower GVHD incidence and severity compared to the tail vein injection group.
- The findings suggest that IBM infusion improves stem cell homing and reduces GVHD in allogeneic transplant scenarios.