Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27.

Aim: Quercetin is an effective Hsp27 inhibitor and has been reported to facilitate tumor cell apoptosis. The aim of this study was to investigate whether quercetin could sensitize human glioblastoma cells to temozolomide (TMZ) in vitro.

Methods: Both U251 and U87 human glioblastoma cells were treated with quercetin and/or TMZ for 48 h.