Vaccination coverage survey of children aged 1-3 years in Beijing, China, 2005-2021.

Background: The routine immunization program for children is a primary strategy and a core part of vaccination. Achieving and maintaining high level of vaccination coverage are important to reduce morbidity and mortality caused by vaccine-preventable diseases. In Beijing, annual coverage surveys have been conducted since 2005.

A new technology for reducing anastomotic fistula in the neck after esophageal cancer surgery.

Background: To explore the risk factors and prevention methods of cervical mechanical anastomotic fistula and stenosis after the radical resection of esophageal cancer.

Methods: From March 2018 to November 2018, 128 patients undergoing mechanical anastomosis of esophageal cancer were selected from the Department of Thoracic Surgery of The First Affiliated Hospital of Zhengzhou University. All the enrolled patients were operated on using the Mckeown method, and a retrospective study was conducted.

A novel pathway in NSCLC cells: miR‑191, targeting NFIA, is induced by chronic hypoxia, and promotes cell proliferation and migration.

MicroRNAs (miRs) have emerged as being important in cancer biology. miR‑191 is a conserved miRNA, which has been investigated in detail and is reported to be induced by hypoxia-inducible factor (HIF)‑1α and has an contributory action in the progression of breast, hepatic and pancreatic cancer. However, the effects of miR‑191 in the progression of lung cancer are a subject of debate.

MiR-454 promotes the progression of human non-small cell lung cancer and directly targets PTEN.

Purpose: MicroRNA-454 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to explore the effects of miR-454 in NSCLC tumorigenesis and development.

Upregulation of long noncoding RNA SPRY4-IT1 promotes metastasis of esophageal squamous cell carcinoma via induction of epithelial-mesenchymal transition.

Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in Eastern Asia. Recent studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. In the present study, we find that the expression of lncRNA SPRY4-IT1 is significantly upregulated in ESCC cell lines as compared with human esophageal epithelial cell line HEEC.

Identification of potential plasma biomarkers for esophageal squamous cell carcinoma by a proteomic method.

Among malignant tumors, the mortality rate of esophageal squamous cell carcinoma (ESCC) ranks sixth in the world. Late-stage diagnosis of ESCC increases the mortality. Therefore, more effective biomarkers for early diagnosis of ESCC are necessary.

The role of CCL20/CCR6 axis in recruiting Treg cells to tumor sites of NSCLC patients.

Inflammatory chemokine CCL20 and its receptor CCR6 have been reported to correlate with colorectal cancer patients' metastasis. However, the role of CCL20 in patients with NSCLC is not well defined. In this study, we detected the expression of CCL20 in tumor samples and corresponding adjacent ones (n=71) from patients with NSCLC using RT-PCR and observed that CCL20 showed higher expression in tumor samples (0.

[Safety of different sequential immunization schedules of inactivated poliovirus vaccine and oral poliovirus vaccine primary vaccination].

Objective: To evaluate safety of different sequential immunization schedules of inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) primary vaccination.

Methods: Infants of 2 months old (60-89 days) selected in Beijing, were assigned to four groups, 1 dose IPV plus 2 doses OPV (I-O-O), 2 doses IPV plus 1 dose OPV(I-I-O), 3 doses IPV (I-I-I), and 3 doses OPV (O-O-O), and were vaccinated at the age of 2, 3, 4 months, from 2009 to 2011. The frequencies of systemic as well as local injection site reactions after every dose were recorded and calculated.

[Immunogenicity and safety of a booster dose of inactivated polio vaccine].

Objective: To evaluate the immunogenicity and safety of a boost dose of inactivated polio vaccine (IPV) among children aged 18 months who had been administered with primary doses of IPV.

Methods: Form 2011 to 2012, a total of 97 children were enrolled in the present study who were vaccinated with IPV at 2, 3, 4 months of age and boosted with the same vaccine at 18 months of age. Anti-poliovirus neutralizing antibody titers in serum were measured before and after booster vaccination, geometric mean titers (GMT) and seroprotection rate were calculated.

[Study of immunogenicity after primary vaccination by different sequential program of inactivated poliovirus vaccine and oral poliovirus vaccine].

Objective: To evaluate immunogenicity after primary vaccination by different sequential program of inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV).

Methods: Children of 2 months old (60-89 days) selected in Beijing were assigned to 4 groups, 1 dose IPV plus 2 doses OPV (I-O-O, 122 children), 2 doses IPV plus 1 dose OPV(I-I-O, 103 children), 3 doses IPV (I-I-I, 114 children), and 3 doses OPV (O-O-O, 106 children), and were vaccinated at the age of 2, 3, 4 months. Polio neutralizing antibody titers against poliovirus types 1, 2, and 3 were tested and protective rates were calculated before the 1st dose, after the last dose, and after the 1st and 2nd dose of IPV.

[The epidemiological impact of varicella vaccination in kindergartens, primary and secondary schools in Beijing].

Objective: To study the epidemiological impact of varicella vaccine vaccination on kindergartens and school children in Beijing.

Methods: According to "China Information System for Diseases Control and Prevention", the reported clinical diagnosis varicella cases were tracked in kindergartens, primary and secondary schools whose onset date were from 2008 to 2010. Epidemiological survey was conducted and epidemiological features were analyzed.

MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2.

Introduction: Overexpression of the enhancer of zeste homolog 2 (EZH2) protein has been found in broad range of cancer types, including non-small cell lung cancer (NSCLC). Nevertheless, the mechanisms by which EZH2 becomes overexpressed in NSCLC remain unclear. MicroRNAs (miRNAs) can regulate target gene expression through translational control.

[Analysis of adverse events following 2009 influenza A (H1N1) vaccinoprophylaxis in Beijing].

Objective: To evaluate the safety of 2009 influenza A (H1N1) vaccine based on mass immunization initiative in Beijing.

Method: There were 2 113 280 people were vaccinated during September to December 2009. The information of adverse events following immunization (AEFI) was collected through surveillance system, and descriptive methodology was used for data analysis.

[Safety and epidemiological effects of the first China-made mass A (H1N1) influenza vaccination].

Objective: To evaluate the safety and epidemiological effects on the first mass vaccination program, using the China-made A (H1N1) influenza vaccine.

Methods: Descriptive epidemiology and cohort study design were used to assess the influenza A H1N1 vaccine on its safety and epidemiological effects.

Results: 95 244 subjects were immunized with A (H1N1) influenza vaccine.

[Herd immunity against new influenza A (H1N1) in pre-vaccinated residents aged over 5 years in Beijing].

Objective: To explore the herd immunity against influenza A (H1N1) in pre-vaccinated residents aged over 5 years, and therefore to provide data for vaccination policies in high risk populations.

Methods: From October to December 2009, Beijing CDC conducted a serum survey of the novel influenza A (H1N1) in the local residents, stratified in 10 age groups between 5 years to over 60 years, without H1N1 vaccination history and disease history. Hemagglutination inhibition (HI) assays were performed at Beijing CDC.

[Analysis of diphtheria antibody levels in healthy population in Beijing municipal, 2007].

Objective: To investigate the diphtheria antibody level in healthy population in Beijing.

Methods: 10 age groups (< 1, 1 to 4, 5 to 9, 10 to 14, 15 to 19, 20 to 24, 25 to 29, 30 to 34, 35 to 39, and > or =40) were sampled by the Multi-stage stratified sampling method in 9 districts in Beijing, and 2 003 sera from healthy population were collected. The diphtheria antibody was determined with ELISA method.

[Comparison between early outbreak detection models and simulated outbreaks of measles in Beijing].

Objective: Using simulated outbreaks to choose the optimal model and its related parameters on measles so as to provide technical support for developing an Auto Warning System (AWS).

Methods: AEGIS-Cluster Creation Tool was applied to simulate a range of unique outbreak signals. Then these simulations were added to the actual daily counts of measles from the National Disease Surveillance System, between 2005 and 2007.

[Study on the risk factors related to severe acute respiratory syndrome among close contactors in Beijing].

Objective: To understand the risk factors on severe acute respiratory syndrome (SARS) among their contacts and to develop effective strategy for its control.

Methods: Available epidemiological data of SARS cases and close contacts were reviewed and analyzed by SPSS.

Results: Out of the 2195 close contacts, 138 (6.