Publications by authors named "Dong-Kyu Oh"
Article Synopsis
- - Sepsis poses significant risks to elderly patients (aged ≥ 80) due to their complex health issues, prompting a study to evaluate how underlying conditions and adherence to sepsis treatment protocols affect their outcomes.
- - The study analyzed data from nearly 12,000 patients, revealing that older survivors had better compliance with sepsis treatment bundles, including early fluid therapy and appropriate antibiotic use, compared to those who did not survive.
- - Findings emphasize the need for personalized treatment strategies and heightened awareness of the specific issues faced by older patients, suggesting that future research should focus on improving sepsis care interventions for this demographic.
Background: The distinction between culture-positive sepsis and culture-negative sepsis regarding clinical characteristics and outcomes remains contentious. We aimed to elucidate these differences using large-scale nationwide data.
Methods: This prospective cohort study analyzed data from the Korean Sepsis Alliance registry, comprising 21 intensive care units (ICUs) across 20 hospitals from September 2019 to December 2021.
Article Synopsis
- About 62.3% of critically ill patients admitted for sepsis developed acute kidney injury (SA-AKI) during their hospital stay.
- The study found that severe SA-AKI significantly increased the risk of in-hospital mortality among these patients.
- Proper hydration and fluid resuscitation within the first hour of treatment were linked to lower mortality rates in patients with severe SA-AKI.
This study investigates the hydrogen embrittlement behavior of API X70 linepipe steel. The microstructure was primarily composed of a dislocation-rich bainitic microstructure and polygonal ferrite. Slow strain-rate tests (SSRTs) were performed under both ex situ and in situ electrochemical hydrogen charging conditions to examine the difference between hydrogen diffusion and trapping behaviors.
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- A study looked at how to predict frailty (weakness) in patients after they recover from sepsis (a serious infection).
- Researchers used data from a large number of patients in Korea to create a machine learning model that could help with this prediction.
- The best model, called Extreme Gradient Boosting, did a great job in predicting frailty, both with the original patient data and data from COVID-19 patients.
Background: The potential adverse effects associated with invasive mechanical ventilation (MV) can lead to delayed decisions on starting MV. We aimed to explore the association between the timing of MV and the clinical outcomes in patients with sepsis ventilated in intensive care unit (ICU).
Methods: We analyzed data of adult patients with sepsis between September 2019 and December 2021.
Objectives: Sepsis is a leading global cause of mortality, and predicting its outcomes is vital for improving patient care. This study explored the capabilities of ChatGPT, a state-of-the-art natural language processing model, in predicting in-hospital mortality for sepsis patients.
Methods: This study utilized data from the Korean Sepsis Alliance (KSA) database, collected between 2019 and 2021, focusing on adult intensive care unit (ICU) patients and aiming to determine whether ChatGPT could predict all-cause mortality after ICU admission at 7 and 30 days.
Article Synopsis
- The study highlights the high mortality rate of patients on the lung transplant waitlist in Korea, necessitating fair allocation policies due to a shortage of donors.
- Researchers simulated the Eurotransplant lung allocation score (ET-LAS) using data from the Korean Organ Transplantation Registry (KOTRY) to evaluate the current urgency-based system.
- Findings suggest that the existing allocation criteria may not effectively prioritize patients based on urgency, particularly for those not in the highest urgency status, indicating a need for policy revision.
Various electrocardiographic changes occur during sepsis, but data on the clinical importance of a low QRS voltage in sepsis are still limited. We aimed to evaluate the association between low QRS voltage identified early in sepsis and mortality in patients with sepsis. Between September 2019 and December 2020, all consecutive adult patients diagnosed with sepsis in the emergency room or general ward at Samsung Medical Center were enrolled.
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- - Successful liberation from mechanical ventilation is essential for patients recovering from respiratory failure, marking their transition out of intensive care and towards normal life.
- - A thorough review of existing studies using the GRADE method resulted in evidence-based recommendations for clinicians, focusing on when patients are ready to breathe independently.
- - The guidelines include nine key questions about ventilator liberation, offering seven conditional recommendations, one expert consensus, and one deferred recommendation to improve patient outcomes.
Article Synopsis
- A study compared two periods: one without intensivist staffing and one with, revealing a significant increase in first-pass success rates and better compliance with emergency protocols during the staffed period.
- Results indicated earlier intubation decisions and reduced post-intubation complications, highlighting the importance of having dedicated intensivists in improving patient safety and MET performance.
Article Synopsis
- Current mortality risk models may not meet the specific needs of sepsis patients, prompting the development of a new predictive model aimed at accurately forecasting 28-day mortality in various care settings.
- This study utilized a large dataset of 7,436 sepsis patients from 20 hospitals for model development and validated it with 2,284 patients from 15 hospitals, showing solid performance in predicting mortality.
- The newly created point system model is accessible online, user-friendly, and successfully predicts outcomes for both community-acquired and hospital-acquired sepsis patients.
Background: Although several trials were conducted to optimize the oxygenation range in intensive care unit (ICU) patients, no studies have yet reached a universal recommendation on the optimal a partial pressure of oxygen in arterial blood (PaO) range in patients with sepsis. Our aim was to evaluate whether a relatively high arterial oxygen tension is associated with longer survival in sepsis patients compared with conservative arterial oxygen tension.
Methods: From the Korean Sepsis Alliance nationwide registry, patients treated with liberal PaO (PaO ≥ 80 mm Hg) were 1:1 matched with those treated with conservative PaO (PaO < 80 mm Hg) over the first three days after ICU admission according to the propensity score.
Objectives: In 2018, the Centers for Disease Control and Prevention introduced the Adult Sepsis Event (ASE) definition, using electronic health records (EHRs) data for surveillance and sepsis quality improvement. However, data regarding ASE outside the United States remain limited. We therefore aimed to validate the diagnostic accuracy of the ASE and to assess the prevalence and mortality of sepsis using ASE.
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- Successful liberation from mechanical ventilation is crucial for patients transitioning out of intensive care, and both individual healthcare experiences and systematic methods are important for this process.
- The Korean Society of Critical Care Medicine reviewed numerous studies using meta-analyses to create evidence-based recommendations for clinicians on how to determine when patients are ready to breathe on their own.
- The guidelines include recommendations on nine specific questions related to ventilator liberation, comprising seven conditional recommendations, one expert consensus, and one conditional deferred recommendation, aimed at optimizing patient care.
Article Synopsis
- * Out of 1,194 septic shock patients, 392 were analyzed; those with normal left ventricular (LV) ejection fraction showed a significant correlation between better shock index values and improved survival.
- * The findings suggest that shock indices are valuable for predicting mortality in septic shock patients with normal LV function but not in those with decreased LV function, highlighting the need to consider cardiac status when evaluating these indices.
Article Synopsis
- Prolonged hospital stays before the onset of sepsis significantly increase the risk of in-hospital mortality.
- A study analyzed data from 1,395 patients across multiple hospitals, comparing those who developed sepsis after less than 5 days in the hospital to those who did so after 5 days or more.
- The results indicated a threefold increase in mortality risk for late-onset sepsis patients, emphasizing the need for improved management in cases where sepsis develops after a longer hospitalization.
Background: There is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate outcomes of polymicrobial bloodstream infections compared to monomicrobial bloodstream infections.
Methods: This study used data from the Korean Sepsis Alliance Registry, a nationwide database of prospective observational sepsis cohort.
Importance: The prevalence of obesity is increasing in the intensive care unit (ICU). Although obesity is a known risk factor for chronic kidney disease, its association with early sepsis-associated acute kidney injury (SA-AKI) and their combined association with patient outcomes warrant further investigation.
Objective: To explore the association between obesity, early SA-AKI incidence, and clinical outcomes in patients with sepsis.
Background: Worldwide, sepsis is the leading cause of death in hospitals. If mortality rates in patients with sepsis can be predicted early, medical resources can be allocated efficiently. We constructed machine learning (ML) models to predict the mortality of patients with sepsis in a hospital emergency department.
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- A study was conducted on severe community-acquired pneumonia (CAP) patients to compare those with bacteremia (blood infection) to those without, focusing on clinical characteristics and outcomes.
- The results showed that bacteremia was present in 14% of severe CAP patients, with a higher occurrence of septic shock and increased hospital mortality in the bacteremia group.
- Key factors linked to bacteremia included hematologic malignancies and septic shock, while chronic lung disease appeared to lower the risk of developing bacteremia in these patients.*
Background: Investigations of the impact of sepsis on the Eastern Cooperative Oncology Group performance status (ECOG PS) of fully ambulatory patients are scarce.
Methods: This is a retrospective analysis of prospectively collected nationwide data on septic patients recruited from 19 hospitals of the Korean Sepsis Alliance between August 2019 and December 2020. Adult septic patients with good ECOG PS (i.
Background: The optimal strategy for fluid management during the first few days of ICU in sepsis patients remains controversial. We aimed to investigate the impact of cumulative fluid balance during the first three days of ICU on the mortality of patients with sepsis.
Methods: This study analyzed prospectively collected data from the Korean Sepsis Alliance Database, which registered 11,981 sepsis patients from 20 hospitals.
Background: This study aimed to evaluate whether the effect of tachycardia varies according to the degree of tissue perfusion in septic shock.
Methods: Patients with septic shock admitted to the intensive care units were categorized into the tachycardia (heart rate > 100 beats/min) and non-tachycardia (≤ 100 beats/min) groups. The association of tachycardia with hospital mortality was evaluated in each subgroup with low and high lactate levels, which were identified through a subpopulation treatment effect pattern plot analysis.
We investigated the correlation between standardized uptake value (SUV) of F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and conductivity parameters in breast cancer and explored the feasibility of conductivity as an imaging biomarker. Both SUV and conductivity have the potential to reflect the tumors' heterogeneous characteristics, but their correlations have not been investigated until now. Forty four women diagnosed with breast cancer who underwent breast MRI and F-FDG PET/CT at the time of diagnosis were included.
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