Clinical Significance of Incident Osteoporotic Fractures After Kidney Transplantation: A National Korean Cohort Study.

Rationale & Objective: Recipients of kidney allografts are at risk for osteoporotic fractures (OF), but their association with patient and allograft outcomes remains uncertain due to common coexisting risks and complex medical conditions. This study sought to assess if overall incidence of OF among recipients of kidney allografts compared to patients receiving maintenance dialysis for kidney failure.

Study Design: A national retrospective cohort study.

Effects of dietary fatty acid on all-cause mortality according to the kidney function based on the nationwide population study.

Background: Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status.

Methods: We used data from the U.S.

Sex-Specific Impact of Serum Calcium Levels on Acute Coronary Syndrome Risk: A 19-Year Cohort Study in Korea.

This study aims to investigate the association between serum calcium levels and acute coronary syndrome (ACS) risk, examining whether this relationship differs by sex, given the known differences in calcium metabolism and hormonal influences between males and females. Utilizing the Korean Genome Epidemiology Study (KoGES) prospective cohort data, our primary exposure variables were serum calcium level and sex. The incidence of ACS served as the main outcome of interest.

Synergistic effect of periodontitis and C-reactive protein levels on mortality: NHANES 2001-2004.

Periodontitis is associated with elevated C-reactive protein (CRP) levels. Although the coexistence of periodontitis and elevated CRP levels may heighten the risk of mortality, previous studies have not confirmed their synergistic effect. Understanding this interaction is crucial for identifying potential interventions to reduce mortality risk in individuals with periodontitis.

Potential benefits of hormone replacement therapy on cardiovascular and kidney outcomes in postmenopausal women with chronic kidney disease.

Background: Hormone replacement therapy (HRT) is recommended for alleviating vasomotor symptoms or preventing bone loss in postmenopausal women. This study aimed to investigate the impact of hormone replacement therapy on major adverse cardiovascular events, kidney failure, and mortality in women with chronic kidney disease (CKD).

Methods: This population-based cohort study analyzed data from the National Cancer Screening Program and the national health examination of South Korea.

Conventional machine learning-based prediction models did not outperform the International IgA Nephropathy Prediction Tool.

Background: Immunoglobulin A nephropathy (IgAN) is a major cause of end-stage kidney disease (ESKD). The International IgA Nephropathy Prediction Tool (IIgAN-PT) predicts IgAN prognosis, but improvement in the prediction performance using machine learning (ML)-based methods is needed.

Methods: We analyzed 4,425 biopsy-confirmed patients with IgAN and ≥6 months of follow-up from nine tertiary university hospitals in Korea.

Bioimpedance-Guided Fluid Removal in Continuous KRT: The VENUS Randomized Clinical Trial.

Key Points: This study, the sole randomized trial of its kind, proposes guidelines for fluid balance management in continuous KRT (CKRT) patients using bioimpedance. Despite this, bioimpedance analysis–guided volume management did not influence the proportion of patients achieving estimated euvolemia at 7 days into CKRT. Further investigation is needed to assess whether bioimpedance analysis guidance can facilitate rapid fluid removal in the early phase of CKRT for patients with AKI.

Association between Secondhand Smoke Exposure and the Incidence of Stroke in Never Smoker According to Alcohol Intake: 19-Year Prospective Cohort Study in Korea.

Objectives: Our study aimed to investigate both the independent and combined effects of secondhand smoking (SHS) and alcohol intake on the occurrence of stroke.

Methods: Utilizing the Korean Genome Epidemiology Study prospective cohort data, our primary exposure variables were SHS exposure and alcohol intake. The occurrence of stroke served as the main outcome of interest.

Impact of hyperuricemia on CKD risk beyond genetic predisposition in a population-based cohort study.

The bidirectional effect of hyperuricemia on chronic kidney disease (CKD) underscores the importance of hyperuricemia as a risk factor for CKD. We evaluated the effect of hyperuricemia on the presence and development of CKD after considering genetic background by calculating polygenic risk scores (PRSs). We employed genome-wide association study summary statistics-excluding the United Kingdom Biobank (UKB) datasets among published CKD Gen Consortium papers-to calculate the PRSs for CKD in white background subjects.

Validation of neuron-specific enolase in cardiac arrest patients with limited withdrawal of life-sustaining therapy.

Aim: We validated the prognostic performance of neuron-specific enolase (NSE) according to the recommended values in cardiac arrest (CA) survivors.

Methods: We analyzed the data of adult CA survivors who underwent targeted temperature management between January 2014 and December 2020. We measured the NSE level 48 h and 72 h after CA.

Surviving the cold: Assessing long-term outcomes among Korean CKD patients exposed to low perceived temperature during winter.

Perceived temperature (PT), which encompasses meteorological factors such as wind speed, cloud cover, and humidity, reflects the actual effect of temperature on the human body. However, limited data exist on the health implications of prolonged exposure to low temperatures during winter in individuals with chronic kidney disease (CKD). We investigated the association between winter PT and long-term outcomes among CKD patients.

Protective effect of Cyclo(His-Pro) on peritoneal fibrosis through regulation of HDAC3 expression.

Peritoneal dialysis is a common treatment for end-stage renal disease, but complications often force its discontinuation. Preventive treatments for peritoneal inflammation and fibrosis are currently lacking. Cyclo(His-Pro) (CHP), a naturally occurring cyclic dipeptide, has demonstrated protective effects in various fibrotic diseases, yet its potential role in peritoneal fibrosis (PF) remains uncertain.

Sex disparity in stroke risk among patients with insomnia: a 19-year prospective cohort study.

Study Objectives: Considering the increased prevalence and more severe manifestations of insomnia among females along with established sex differences in ischemic stroke (IS) occurrence, this research aimed to examine the potential effects of the interaction between insomnia and sex on the incidence and outcome of IS.

Methods: We used data from the Korean Genome and Epidemiology Study. The main exposure variables were insomnia history and sex.

Oral phosphate binders and incident osteoporotic fracture in patients on dialysis.

Background And Hypothesis: End-stage kidney disease (ESKD) has an elevated risk of osteoporotic fractures in relation to mineral and bone disorder (MBD) as well as conventional risks of osteoporosis. We investigated the association between oral phosphate binders, the mainstay of MBD treatment, and osteoporotic fracture in dialysis patients.

Methods: We obtained data from the National Health Insurance database for incident dialysis patients without a history of osteoporotic fractures.

Glomerular crescents are associated with the risk of type 2 diabetic kidney disease progression: a retrospective cohort study.

Background: Diabetic kidney disease (DKD) stands as the predominant cause of chronic kidney disease and end-stage kidney disease. Its diverse range of manifestations complicates the treatment approach for patients. Although kidney biopsy is considered the gold standard for diagnosis, it lacks precision in predicting the progression of kidney dysfunction.

Associations of MRI-derived kidney volume, kidney function, body composition and physical performance in ≈38 000 UK Biobank participants: a population-based observational study.

Background: Kidney volume is used as a predictive and therapeutic marker for several clinical conditions. However, there is a lack of large-scale studies examining the relationship between kidney volume and various clinicodemographic factors, including kidney function, body composition and physical performance.

Methods: In this observational study, MRI-derived kidney volume measurements from 38 526 UK Biobank participants were analysed.

Risk of mortality and cause of death according to kidney function parameters: a nationwide observational study in Korea.

Background: Further study is warranted to determine the association between estimated glomerular filtration rate (eGFR) or albuminuria and the risk of death from diverse causes.

Methods: We screened >10 million general health screening examinees who received health examinations conducted in 2009 using the claims database of Korea. After the exclusion of those previously diagnosed with renal failure and those with missing data, 9,917,838 individuals with available baseline kidney function measurements were included.