Publications by authors named "Dong-Ju Choi"
Background: Adherence to oral anticoagulant therapy is essential to prevent ischemic stroke in patients with atrial fibrillation (AF).
Objective: This study aimed to evaluate whether smartphone app-based interventions improve medication adherence in patients with AF.
Methods: This open-label, multicenter randomized controlled trial (ADHERE-App [Self-Awareness of Drug Adherence to Edoxaban Using an Automatic App Feedback System] study) enrolled patients with AF treated with edoxaban for stroke prevention.
Background And Objectives: The Korean Organ Transplant Registry (KOTRY) provided data for this third official report on adult heart transplantation (HT), including information from 709 recipients.
Methods: Data from HTs performed at seven major centers in Korea between March 2014 and December 2020 were analyzed, focusing on immunosuppression, acute rejection, cardiac allograft vasculopathy (CAV), post-transplant survival, and mechanical circulatory support (MCS) usage.
Results: The median ages of the recipients and donors were 56.
Article Synopsis
- - The study compared the effectiveness and safety of a combination therapy (amlodipine + candesartan cilexetil) versus amlodipine alone in treating patients with essential hypertension who had not achieved adequate blood pressure control.
- - Results showed that patients on the combination therapy experienced significantly greater reductions in both diastolic and systolic blood pressure compared to those on amlodipine alone.
- - The incidence of adverse events was slightly higher in the combination therapy group, but overall, it was well-tolerated, suggesting it could be a beneficial option for patients not properly managed with amlodipine alone.
The Fabry-Pérot interferometer, a fundamental component in optoelectronic systems, offers interesting applications such as sensors, lasers, and filters. In this work, we show a tunable Fabry-Pérot cavity consisting of tunable Sagnac loop reflectors (SLRs) and phase shifters based on electrostatic microelectromechanical (MEMS) actuator. The fabrication process of the device is compatible with the standard wafer-level silicon photonics fabrication processes.
View Article and Find Full Text PDFArticle Synopsis
- Cachexia and sarcopenia are prevalent in heart failure patients, negatively affecting their survival, prompting this study to explore how serum creatinine levels relate to mortality in acute heart failure patients.
- The study included 5,198 acute heart failure patients, categorized by serum creatinine levels into five groups, with a focus on post-discharge all-cause mortality and finding a J-shaped relationship between creatinine levels and mortality rates.
- Results revealed that both low (<0.6 mg/dL) and high creatinine levels increased mortality risk, with low levels raising the risk of all-cause mortality by 33% after accounting for various health factors.
Differential Effect of Sex on Mortality According to Age in Heart Failure.
J Am Heart Assoc
August 2024
Background: Heart failure exhibits sex-based differences in prevalence, clinical characteristics, and outcomes. However, these differences may have an interaction with age. This study investigates these disparities in Asian patients with acute heart failure according to age.
View Article and Find Full Text PDFBackground: Although several biomarkers exist for patients with heart failure (HF), their use in routine clinical practice is often constrained by high costs and limited availability.
Objective: We examined the utility of an artificial intelligence (AI) algorithm that analyzes printed electrocardiograms (ECGs) for outcome prediction in patients with acute HF.
Methods: We retrospectively analyzed prospectively collected data of patients with acute HF at two tertiary centers in Korea.
Background And Objectives: The number of sensitized heart failure patients on waiting lists for heart transplantation (HTx) is increasing. Using the Korean Organ Transplantation Registry (KOTRY), a nationwide multicenter database, we investigated the prevalence and clinical impact of calculated panel-reactive antibody (cPRA) in patients undergoing HTx.
Methods: We retrospectively reviewed 813 patients who underwent HTx between 2014 and 2021.
Article Synopsis
- Beta-blockers, like carvedilol, may help heart failure patients, but their effectiveness in heart failure with preserved ejection fraction (HFpEF) is not well understood, particularly based on heart strain measurements.
- This study, known as CARE-preserved HF, will recruit 100 HFpEF patients with hypertension and examine how carvedilol-SR affects their heart-related outcomes over 6 months, comparing results between those receiving the drug and those given a placebo.
- The main goal is to see how much NT-proBNP levels change, as this marker indicates heart strain, and to analyze the results based on different levels of global longitudinal strain (GLS).
Background And Objectives: The number of people with heart failure (HF) is increasing worldwide, and the social burden is increasing as HF has high mortality and morbidity. We aimed to provide updated trends on the epidemiology of HF in Korea to shape future social measures against HF.
Methods: We used the National Health Information Database of the National Health Insurance Service to determine the prevalence, incidence, hospitalization rate, mortality rate, comorbidities, in-hospital mortality, and healthcare cost of patients with HF from 2002 to 2020 in Korea.
Unlabelled: With advancements in both pharmacologic and non-pharmacologic treatments, significant changes have occurred in heart failure (HF) management. The previous Korean HF registries, namely the Korea Heart Failure Registry (KorHF-registry) and Korean Acute Heart Failure Registry (KorAHF-registry), no longer accurately reflect contemporary acute heart failure (AHF) patients. Our objective is to assess contemporary AHF patients through a nationwide registry encompassing various aspects, such as clinical characteristics, management approaches, hospital course, and long-term outcomes of individuals hospitalized for AHF in Korea.
View Article and Find Full Text PDFAnatomical study to determine a new approach to treat benign masses located in the anterior condyle region: a case report.
J Korean Assoc Oral Maxillofac Surg
April 2024
A 22-year-old male patient presented to the clinic with severe pain in the preauricular area with an inability to completely occlude the jaw. Facial computed tomography and magnetic resonance imaging revealed a well-defined lesion that was tentatively diagnosed as a benign tumor or cystic mass. Surgical approach of a lesion in the condyle is delicate and problematic as many vulnerable anatomical structures are present.
View Article and Find Full Text PDFArticle Synopsis
- Current heart failure (HF) guidelines recommend a comprehensive approach for management, including patient education and self-care, but implementing these recommendations is difficult in practice.
- A study was conducted to test a mobile health (mHealth) platform that pairs a smartphone app with Bluetooth monitoring devices to improve self-management and symptoms of heart failure.
- Results showed that the intervention group reported significantly better symptom improvement and adherence to the app compared to the control group, demonstrating the potential benefits of technology in managing HF.
The effect of changes in immunosuppressive therapy during the acute phase post-heart transplantation (HTx) on clinical outcomes remains unclear. This study aimed to investigate the effects of changes in immunosuppressive therapy by corticosteroid (CS) weaning and everolimus (EVR) initiation during the first year post-HTx on clinical outcomes. We analyzed 622 recipients registered in the Korean Organ Transplant Registry (KOTRY) between January 2014 and December 2021.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the eligibility of heart failure patients for dapagliflozin and its cost-effectiveness compared to standard therapy, using data from the Korean Acute Heart Failure registry.
- About 48.7% of the patients met eligibility criteria from previous clinical trials, with higher eligibility found in those with preserved ejection fraction.
- Dapagliflozin was found to be cost-effective, especially for patients with a left ventricular ejection fraction of 40% or less, showing a significant benefit in quality-adjusted life years at a cost well below standard willingness-to-pay thresholds.
The prevalence of heart failure (HF) is increasing, necessitating accurate diagnosis and tailored treatment. The accumulation of clinical information from patients with HF generates big data, which poses challenges for traditional analytical methods. To address this, big data approaches and artificial intelligence (AI) have been developed that can effectively predict future observations and outcomes, enabling precise diagnoses and personalized treatments of patients with HF.
View Article and Find Full Text PDFArticle Synopsis
- The FDA and EMA approved empagliflozin for reducing cardiovascular mortality and heart failure hospitalization in patients with HFrEF and HFpEF, but its real-world applicability is unclear.
- A study analyzing data from the Korean Acute Heart Failure (KorAHF) registry found that 91.4% of patients met FDA/EMA criteria, while only 44.7% met trial criteria.
- Empagliflozin was determined to be cost-effective at $6,764 per quality-adjusted life year (QALY), particularly for HFrEF patients ($5,012 per QALY), indicating potential benefits in clinical settings in South Korea.
Aims: Although the hypothesis that metformin is beneficial for patients with diabetes and heart failure (HF) has been steadily raised, there is limited data on metformin use in patients with acute HF. We analyzed the association of metformin on all-cause mortality in hospitalized patients with type 2 diabetes and acute HF.
Methods: The Korean Acute Heart Failure registry prospectively enrolled patients hospitalized for acute HF from 2011 to 2014.
Background/aims: Sex differences in the prognosis of heart failure (HF) have yielded inconsistent results, and data from Asian populations are even rare. This study aimed to investigate sex differences in clinical characteristics and long-term prognosis among Korean patients with HF.
Methods: A total of 5,625 Korean patients hospitalized for acute HF were analyzed using a prospective multi-center registry database.
Article Synopsis
- * In a trial with 374 hypertensive patients, those receiving the triple therapy saw a significant decrease in mean sitting systolic blood pressure after 8 weeks compared to the dual therapy group.
- * Results indicated that the triple therapy led to higher rates of achieving target blood pressure and a lower occurrence of adverse events, especially among women and patients aged 65 and older.
Correction: Comparison of 2‑year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry.
Cardiovasc Diabetol
June 2023
Article Synopsis
- - This study evaluates the effectiveness of a smartphone app designed to improve medication adherence in patients with atrial fibrillation (AF) who are prescribed non-vitamin K antagonist oral anticoagulants (NOACs), which is critical for stroke prevention.
- - The RIVOX-AF trial will enroll 1,042 participants across 13 hospitals in South Korea, randomly assigning them to either the app-based intervention group or a control group to compare adherence levels over 24 weeks.
- - Key outcomes being measured include adherence rates assessed by pill counts and clinical events such as strokes or major bleeding incidents during the follow-up period.
Background: Although iron deficiency (ID) is an important and treatable risk factor for heart failure (HF), data on ID are scarce in Asian patients with HF. Therefore, we sought to determine the prevalence and clinical characteristics of ID in hospitalized Korean patients with HF.
Methods: In this prospective, multicenter cohort study, 461 patients with acute HF seen at five tertiary centers from January to November 2019 in Korea were enrolled.
Background: Takotsubo syndrome (TTS) with physical triggers has worse short- and long-term clinical courses than those with emotional triggers. However, predictive factors associated with poor outcomes of TTS with physical triggers are unknown.
Methods: We included 231 patients identified as TTS preceded by physical triggers at two tertiary referral hospitals from 2010 to 2019.
Background: High C-reactive protein (CRP) levels are associated with poor outcomes of heart failure (HF), and statins are known to reduce CRP levels. We investigated the prognostic value of CRP and statin in patients with HF with reduced and preserved ejection fraction (EF).
Methods: Altogether, 3,831 patients from the Korean Acute Heart Failure registry were included and stratified according to the tertiles of CRP levels (T1: CRP < 0.