Publications by authors named "Dong-Hao Shang"
Introduction: mTOR and MDM2 signaling pathways are frequently deregulated in cancer development, and inhibition of mTOR or MDM2 independently enhances carcinoma-cell apoptosis. However, responses to mTOR and MDM2 antagonists in renal cell carcinoma (RCC) remain unknown.
Materials And Methods: A498 cells treated with MDM2 antagonist MI-319 and/or mTOR inhibitor rapamycin were employed in the present study.
Article Synopsis
- Docetaxel (DOC) is an effective treatment for hormone refractory prostate cancer (HRPC), and this study investigates if rapamycin (RPM) can enhance the effects of DOC on prostate cancer cells.
- In laboratory tests, RPM and DOC both inhibited prostate cancer cell growth in a dose-dependent manner, with their combination leading to greater anti-tumor effects and increased cell death (apoptosis) compared to either treatment alone.
- The study also demonstrated that RPM increased the activation of specific caspases associated with apoptosis, further supporting the idea of a synergistic relationship between RPM and DOC in fighting prostate cancer.
[Comparison of holmium and thulium laser in transurethral enucleation of the prostate].
Zhonghua Nan Ke Xue
April 2009
Objective: To investigate and compare the effect and safety of Holmium laser and Thulium laser in transurethral enucleation of the prostate in BPH patients.
Methods: Ninety-eight BPH patients were divided into 2 groups and underwent transurethral enucleation of the prostate with holmium laser (Ho group) and thulium laser (Th group) respectively. Comparisons were made between the 2 groups in operation time, bleeding volume, electrolyte, IPSS score, PVR and Qmax.