Novel coumarin-thiazolyl ester derivatives as potential DNA gyrase Inhibitors: Design, synthesis, and antibacterial activity.

The design and synthesis of novel coumarin-thiazolyl ester derivatives of potent DNA gyrase inhibitory activity were the main aims of this study. All the novel synthesized compounds were examined for their antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Salmonella. Compound 8p exhibited excellent antibacterial activity against four bacteria strains with MIC values of 0.

Discovery of novel multi-substituted benzo-indole pyrazole schiff base derivatives with antibacterial activity targeting DNA gyrase.

The design and synthesis of novel multi-substituted benzo-indole pyrazole Schiff base derivatives of potent DNA gyrase inhibitory activity were the main aims of this study. All the novel synthesized compounds were examined for their antibacterial activities against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella. In addition, we selected 20 compounds for the in vitro antibacterial activities assay of 6 drug-resistant bacteria strains.

A bioactivity-oriented modification strategy for SDH inhibitors with superior activity against fungal strains.

In this work, a total of 36 novel 5-(nicotinamido)-1-phenyl-1H-pyrazole-4-carboxylic acid derivatives were designed and synthesized successfully by introducing a carboxyl group based on the N-(1-(4-chlorophenyl)-4-cyano-1H-pyrazol-5-yl)-6-methoxynicotinamide. Among them, the growth inhibition assays on agar plates showed that compound 5IV-d(5-(2-chloronicotinamido)-1-(p-tolyl)-1H-pyrazole-4-carboxylic acid) exhibited the significant antifungal activity against four important fruit and main crop disease fungi (i.e.

Poly[[hexa-aqua-(μ(3)-2,2'-bipyridine-4,4',6,6'-tetra-carboxyl-ato-κ(6)O(4):N,O(6),O(6'),N':O(4'))dinickel(II)] dihydrate].

In the title complex, {[Ni(2)(C(14)H(4)N(2)O(8))(H(2)O)(6)]·2H(2)O}(n), the two Ni(II) atoms are located in different special positions (one on a twofold rotation axis and the second on a centre of symmetry) and have different distorted octa-hedral environments (one by two N atoms from a bipyridine unit, two O atoms from two water mol-ecules and two O atoms from two carboxyl-ate groups, and the second by four O atoms from four water mol-ecules and two O atoms from two carboxyl-ate groups). Thus, the environments of the Ni(II) atoms may be denoted as NiN(2)O(4) and NiO(6). In the crystal, there exists an extensive network of classical O-H⋯O hydrogen bonds.

Bis[μ-3-(1H-benzimidazol-2-yl)benzoato]dicopper(I).

The dimeric title complex, [Cu(2)(C(14)H(9)N(2)O(2))(2)], resides on a center of symmetry. In the crystal, the mol-ecules are packed via π-π stacking inter-actions alternating between imidazole and benzene rings [mean inter-planar distances = 3.754 (3) and 3.

1-Methyl-3,5-bis-(3-methyl-phen-yl)benzene.

In the title compound, C(21)H(20), the dihedral angles formed by the central benzene ring with the outer benzene rings are 21.43 (6) and 31.70 (4)°.

1,3-Bis(3,5-dimethyl-phen-yl)-5-methyl-benzene.

In the title compound, C(23)H(24), the dihedral angles formed by the central benzene ring with the peripheral benzene rings are 29.90 (5) and 34.95 (5)°.

Actinoplanes sichuanensis sp. nov. and Actinoplanes xinjiangensis sp. nov.

Two motile actinomycetes, designated strains 03-723(T) and 03-8772(T), which had potent inhibitory activity against Enterococcus faecium peptide deformylase and several clinical Gram-positive, antibiotic-resistant strains, were isolated from two soil samples collected from Sichuan Province and Xinjiang Uyghur Autonomous Region in China, respectively. The taxonomic status of these two organisms was established by using a polyphasic approach. The taxonomic data were consistent with the assignment of the strains to the genus Actinoplanes.

Bis{2-[(E)-benzyl-imino-meth-yl]-4-methyl-phenolato-κN,O}nickel(II).

In the title complex, [Ni(C(15)H(14)NO)(2)], the Ni(II) atom is located on an inversion centre and is coordinated by two O and two N atoms from two symmetry-related bidentate Schiff base ligands in a slightly distorted square-planar geometry. The phenyl and benzene rings in the ligand mol-ecule form a dihedral angle of 72.79 (8)°.

2,4-Dibromo-6-{(E)-[(R)-1-phenyl-ethyl]imino-meth-yl}phenol.

In the title Schiff base, C(15)H(13)Br(2)NO, the benzene and phenyl rings form a dihedral angle of 75.18 (13)°. The N=C bond length of 1.